ChemicalBook > CAS DataBase List > UNC0379

UNC0379

Product Name
UNC0379
CAS No.
1620401-82-2
Chemical Name
UNC0379
Synonyms
UNC03;CS-1767;UNC0379;UNC0379, >=98%;UNC0379 USP/EP/BP;UNC 0379; UNC-0379;UNC0379, UNC-0379, UNC 0379;6,7-Dimethoxy-2-(1-pyrrolidinyl)-N-[5-(1-pyrrolidinyl)pentyl]-4-quinazolinamine;4-Quinazolinamine, 6,7-dimethoxy-2-(1-pyrrolidinyl)-N-[5-(1-pyrrolidinyl)pentyl]-;6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine
CBNumber
CB92715675
Molecular Formula
C23H35N5O2
Formula Weight
413.56
MOL File
1620401-82-2.mol
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UNC0379 Property

Boiling point:
606.3±65.0 °C(Predicted)
Density 
1.168±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
solubility 
Soluble in DMSO (up to 30 mg/ml)
pka
10.54±0.20(Predicted)
form 
solid
color 
Tan
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
16400
Product name
UNC0379
Purity
≥95%
Packaging
5mg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
16400
Product name
UNC0379
Purity
≥95%
Packaging
10mg
Price
$130
Updated
2024/03/01
Cayman Chemical
Product number
16400
Product name
UNC0379
Purity
≥95%
Packaging
25mg
Price
$298
Updated
2024/03/01
Axon Medchem
Product number
Axon2418
Product name
UNC0379
Purity
98%
Packaging
10mg
Price
$137.5
Updated
2021/12/16
ApexBio Technology
Product number
B8009
Product name
UNC0379
Packaging
5mg
Price
$158
Updated
2021/12/16
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UNC0379 Chemical Properties,Usage,Production

Description

UNC0379 (CAS 1620401-82-2) is an inhibitor of the lysine methyltransferase SETD8 with selectivity over 15 other methyltransferases.1 IC50’s = 7.3 μM in a radioactive methyl transfer assay and 9.0 μM in an MCE assay. UNC0379 treatment of SY5Y and NGP neuroblastoma cell lines lead to activation of p53 and decreased tumor growth in an ex-vivo tumorigenicity assay.2

References

1) Ma et al. (2014), Discovery of a Selective, Substrate-Competitive Inhibitor of the Lysine Methyltransferase SETD8; J. Med. Chem. 57 6822 2) Veschi et al. (2017), Epigenetic siRNA and Chemical Screens Identify SETD8 Inhibition as a Therapeutic Strategy for p53 Activation in High-Risk Neuroblastoma; Cancer Cell 31 50

UNC0379 Preparation Products And Raw materials

Raw materials

Preparation Products

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UNC0379 Suppliers

China 82 France 1 India 1 The Netherlands 1 United Kingdom 1 United States 14 Global 100
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View Lastest Price from UNC0379 manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
UNC0379 1620401-82-2
Price
US $0.00-0.00/KG
Min. Order
5mg
Purity
99%HPLC
Supply Ability
2000tons
Release date
2020-01-06

1620401-82-2, UNC0379Related Search:

UNC 1999 UNC3230 UNC0321 UNC2881 Y27632 (hydrochloride) TG101209 GO 6983 Paclitaxel GDC-0152 SGC0946 UNC3866 UNC 669 UNC2250 UNC-1215 UNC-926 Hydochloride UNC569 UNC0646 NUC-7738

  • UNC0379
  • 6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine
  • 6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine UNC0379
  • UNC0379, >=98%
  • UNC03
  • 6,7-Dimethoxy-2-(1-pyrrolidinyl)-N-[5-(1-pyrrolidinyl)pentyl]-4-quinazolinamine
  • UNC0379, UNC-0379, UNC 0379
  • UNC 0379; UNC-0379
  • CS-1767
  • 4-Quinazolinamine, 6,7-dimethoxy-2-(1-pyrrolidinyl)-N-[5-(1-pyrrolidinyl)pentyl]-
  • UNC0379 USP/EP/BP
  • 1620401-82-2
  • C23H35N5O2
  • Inhibitors