ChemicalBook > CAS DataBase List > UNC0379

UNC0379

Product Name: UNC0379
CAS No.: 1620401-82-2
Chemical Name: UNC0379
Synonyms: UNC03;CS-1767;UNC0379;UNC0379, >=98%;UNC0379 ，S7570;UNC0379 USP/EP/BP;UNC 0379; UNC-0379;UNC0379, 10 mM in DMSO;UNC0379, UNC-0379, UNC 0379;6,7-Dimethoxy-2-(1-pyrrolidinyl)-N-[5-(1-pyrrolidinyl)pentyl]-4-quinazolinamine
CBNumber: CB92715675
Molecular Formula: C23H35N5O2
Formula Weight: 413.56
MOL File: 1620401-82-2.mol

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UNC0379 Property

Boiling point:: 606.3±65.0 °C(Predicted)
Density: 1.168±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: Soluble in DMSO (up to 30 mg/ml)
pka: 10.54±0.20(Predicted)
form: solid
color: Tan
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 16400
Product name: UNC0379
Purity: ≥95%
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 16400
Product name: UNC0379
Purity: ≥95%
Packaging: 10mg
Price: $130
Updated: 2024/03/01

Cayman Chemical

Product number: 16400
Product name: UNC0379
Purity: ≥95%
Packaging: 25mg
Price: $298
Updated: 2024/03/01

Axon Medchem

Product number: Axon2418
Product name: UNC0379
Purity: 98%
Packaging: 10mg
Price: $137.5
Updated: 2021/12/16

ApexBio Technology

Product number: B8009
Product name: UNC0379
Packaging: 5mg
Price: $158
Updated: 2021/12/16

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UNC0379 Chemical Properties,Usage,Production

Description

UNC0379 (CAS 1620401-82-2) is an inhibitor of the lysine methyltransferase SETD8 with selectivity over 15 other methyltransferases.1 IC50’s = 7.3 μM in a radioactive methyl transfer assay and 9.0 μM in an MCE assay. UNC0379 treatment of SY5Y and NGP neuroblastoma cell lines lead to activation of p53 and decreased tumor growth in an ex-vivo tumorigenicity assay.2

Uses

UNC0379 is a selective, substrate-competitive inhibitor of lysine methyltransferase SETD8 (KMT5A) with an IC50 of 7.3 μM, KD value of 18.3 μM. UNC0379 can be used in the research of inflammation and cancers, such as pulmonary fibrosis, ovarian cancer, neuroblastoma[1][2][3].

in vivo

UNC0379 (intratracheal administration, 1 mg/kg/day, on day7, 8, and 9) ameliorates the lung fibrosis in Bleomycin (BLM)-induced lung fibrosis mouse^[3].

Animal Model:	Bleomycin (BLM)-induced lung fibrosis mouse model^[3]
Dosage:	1 mg/kg/day
Administration:	Intratracheal administration, on day7, 8, and 9.
Result:	Ameliorated BLM-induced lung fibrosis (supported by the evaluation of the Ashcroft score and changes in the collagen content in the lung samples) without affecting pulmonary inflammation.

IC 50

SETD8/KMT5A

References

[1] ANQI MA. Discovery of a Selective, Substrate-Competitive Inhibitor of the Lysine Methyltransferase SETD8[J]. Journal of Medicinal Chemistry, 2014, 57 15: 6822-6833. DOI:10.1021/jm500871s
[2] VERONICA VESCHI. Epigenetic siRNA and Chemical Screens Identify SETD8 Inhibition as a Therapeutic Strategy for p53 Activation in High-Risk Neuroblastoma.[J]. Cancer Cell, 2017, 31 1 1: 50-63. DOI:10.1016/j.ccell.2016.12.002

UNC0379 Preparation Products And Raw materials

Raw materials

Preparation Products

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UNC0379 Suppliers

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1620401-82-2, UNC0379Related Search:

UNC 1999 UNC3230 UNC0321 UNC2881 Y27632 (hydrochloride) TG101209 GO 6983 Paclitaxel GDC-0152 SGC0946 UNC3866 UNC 669 UNC2250 UNC-1215 UNC-926 Hydochloride UNC569 UNC0646 NUC-7738

UNC0379

6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine

6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine UNC0379

UNC0379, >=98%

UNC03

6,7-Dimethoxy-2-(1-pyrrolidinyl)-N-[5-(1-pyrrolidinyl)pentyl]-4-quinazolinamine

UNC0379, UNC-0379, UNC 0379

UNC 0379; UNC-0379

CS-1767

4-Quinazolinamine, 6,7-dimethoxy-2-(1-pyrrolidinyl)-N-[5-(1-pyrrolidinyl)pentyl]-

UNC0379 USP/EP/BP

UNC0379, 10 mM in DMSO

UNC0379 ，S7570

1620401-82-2

C23H35N5O2

Inhibitors