LDC1267

Product Name: LDC1267
CAS No.: 1361030-48-9
Chemical Name: LDC1267
Synonyms: CS-1641;LDC1267;LDC 1267;LDC-1267;LDC1267 USP/EP/BP;LDC 1267,LDC1267,Tyro3,Inhibitor,LDC-1267,inhibit,TAM Receptor,Axl,Mer;N-[4-[(6,7-dimethoxy-4-quinolyl)oxy]-3-fluoro-phenyl]-4-ethoxy-1-(4-fluoro-2-methyl-phenyl)pyrazole-3-carboxamide;N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]-3-fluorophenyl]-4-ethoxy-1-(4-fluoro-2-methylphenyl)-1H-pyrazole-3-carboxamide;N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluoro-2-methylphenyl)-1H-pyrazole-3-carboxamide;1H-Pyrazole-3-carboxamide, N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-3-fluorophenyl]-4-ethoxy-1-(4-fluoro-2-methylphenyl)-
CBNumber: CB02734808
Molecular Formula: C30H26F2N4O5
Formula Weight: 560.55
MOL File: 1361030-48-9.mol

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LDC1267 Property

Boiling point:: 628.4±55.0 °C(Predicted)
Density: 1.32±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: insoluble in H2O; insoluble in EtOH; ≥20.75 mg/mL in DMSO
form: solid
pka: 9.36±0.70(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 29459
Product name: LDC-1267
Packaging: 1mg
Price: $36
Updated: 2024/03/01

Cayman Chemical

Product number: 29459
Product name: LDC-1267
Packaging: 25mg
Price: $553
Updated: 2024/03/01

Cayman Chemical

Product number: 29459
Product name: LDC-1267
Packaging: 5mg
Price: $145
Updated: 2024/03/01

Cayman Chemical

Product number: 29459
Product name: LDC-1267
Packaging: 10mg
Price: $239
Updated: 2024/03/01

AK Scientific

Product number: 1703DN
Product name: CID56847486
Packaging: 5mg
Price: $260
Updated: 2021/12/16

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LDC1267 Chemical Properties,Usage,Production

Biological Activity

LDC1267 is a highly selective TAM kinase inhibitor with IC50s of <5 nM, 8 nM, and 29 nM for Mer, Tyro3, and Axl, respectively. Low activity against Met, Aurora B, Lck, Src, and CDK8.

in vitro

LDC1267 moderately affected proliferation in 11 of 95 different cell lines with IC50 >5 μM. In NKG2D-activated NK cells, it abrogates the inhibitory effect of Gas6 stimulation.

in vivo

In B16F10 melanoma-bearing mice, LDC1267 (20 mg/kg, ip) potently enhanced anti-metastatic NK cell activity and resisted tumor metabolism without severe cytotoxicity.

target

Target	Value
Mer (Cell-free assay)	<5 nM
Tyro3 (Cell-free assay)	8 nM
Axl (Cell-free assay)	29 nM

LDC1267 Preparation Products And Raw materials

Raw materials

Preparation Products

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LDC1267 Suppliers

China 69 India 1 United States 11 Global 81

Wuhan Topule

Tel: +86-02787215551 +86-19945035818
Fax: 027-87215551
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Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
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Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4647
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Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
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AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
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Country: United States
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Shanghai Run-Biotech Co., Ltd.

Tel: 021-57171705 13817537615
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Email: sales@run-biotech.com
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ShangHai KenEn Chemical Technology Co., Ltd.

Tel: 13120367189
Fax: 021-50315529
Email: mychess007@163.com
Country: China
ProdList: 1994
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AdooQ Bioscience CHINA

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Fax: 025-68650336
Email: info@adooq.cn
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LETOPHARM LIMITED

Tel: +86-21-5821 5861
Fax: +86-21-5106 2861
Email: sales@letopharm.com
Country: China
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Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4121
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1361030-48-9, LDC1267Related Search:

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LDC1267

N-[4-[(6,7-dimethoxy-4-quinolyl)oxy]-3-fluoro-phenyl]-4-ethoxy-1-(4-fluoro-2-methyl-phenyl)pyrazole-3-carboxamide

N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]-3-fluorophenyl]-4-ethoxy-1-(4-fluoro-2-methylphenyl)-1H-pyrazole-3-carboxamide

CS-1641

LDC 1267;LDC-1267

1H-Pyrazole-3-carboxamide, N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-3-fluorophenyl]-4-ethoxy-1-(4-fluoro-2-methylphenyl)-

LDC1267 USP/EP/BP

N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluoro-2-methylphenyl)-1H-pyrazole-3-carboxamide

LDC 1267,LDC1267,Tyro3,Inhibitor,LDC-1267,inhibit,TAM Receptor,Axl,Mer

1361030-48-9

136030-48-9

C30H26F2N4O5

Inhibitors