LDC1267

Product Name: LDC1267
CAS No.: 1361030-48-9
Chemical Name: LDC1267
Synonyms: CS-1641;LDC1267;LDC 1267;LDC-1267;LDC1267 USP/EP/BP;LDC1267, 10 mM in DMSO;TAM Receptor Kinase Inhibitor, LDC1267;LDC 1267,LDC1267,Tyro3,Inhibitor,LDC-1267,inhibit,TAM Receptor,Axl,Mer;N-[4-[(6,7-dimethoxy-4-quinolyl)oxy]-3-fluoro-phenyl]-4-ethoxy-1-(4-fluoro-2-methyl-phenyl)pyrazole-3-carboxamide;N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]-3-fluorophenyl]-4-ethoxy-1-(4-fluoro-2-methylphenyl)-1H-pyrazole-3-carboxamide;N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluoro-2-methylphenyl)-1H-pyrazole-3-carboxamide
CBNumber: CB02734808
Molecular Formula: C30H26F2N4O5
Formula Weight: 560.55
MOL File: 1361030-48-9.mol

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LDC1267 Property

Boiling point:: 628.4±55.0 °C(Predicted)
Density: 1.32±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: insoluble in H2O; insoluble in EtOH; ≥20.75 mg/mL in DMSO
form: solid
pka: 9.36±0.70(Predicted)
color: White to off-white
InChIKey: ISPBCAXOSOLFME-UHFFFAOYSA-N
SMILES: N1(C2=CC=C(F)C=C2C)C=C(OCC)C(C(NC2=CC=C(OC3C4C(N=CC=3)=CC(OC)=C(OC)C=4)C(F)=C2)=O)=N1

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 29459
Product name: LDC-1267
Packaging: 1mg
Price: $36
Updated: 2024/03/01

Cayman Chemical

Product number: 29459
Product name: LDC-1267
Packaging: 25mg
Price: $553
Updated: 2024/03/01

Cayman Chemical

Product number: 29459
Product name: LDC-1267
Packaging: 5mg
Price: $145
Updated: 2024/03/01

Cayman Chemical

Product number: 29459
Product name: LDC-1267
Packaging: 10mg
Price: $239
Updated: 2024/03/01

AK Scientific

Product number: 1703DN
Product name: CID56847486
Packaging: 5mg
Price: $260
Updated: 2021/12/16

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LDC1267 Chemical Properties,Usage,Production

Uses

LDC1267 is a highly selective TAM (Tyro3, Axl and Mer) kinase inhibitor with IC50s of <5 nM/8 nM/29 nM for Tyro3,Axl and Mer respectively[1].

Biological Activity

LDC1267 is a highly selective TAM kinase inhibitor with IC50s of <5 nM, 8 nM, and 29 nM for Mer, Tyro3, and Axl, respectively. Low activity against Met, Aurora B, Lck, Src, and CDK8.

in vitro

LDC1267 moderately affected proliferation in 11 of 95 different cell lines with IC50 >5 μM. In NKG2D-activated NK cells, it abrogates the inhibitory effect of Gas6 stimulation.

in vivo

In B16F10 melanoma-bearing mice, LDC1267 (20 mg/kg, ip) potently enhanced anti-metastatic NK cell activity and resisted tumor metabolism without severe cytotoxicity.

target

Target	Value
Mer (Cell-free assay)	<5 nM
Tyro3 (Cell-free assay)	8 nM
Axl (Cell-free assay)	29 nM

IC 50

Axl; Tyro3; Mer

References

[1] Paolino M, et al. The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells. Nature. 2014 Mar 27;507(7493):508-12. DOI:10.1038/nature12998

LDC1267 Preparation Products And Raw materials

Raw materials

Preparation Products

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LDC1267 Suppliers

China 88 India 1 United States 11 Global 100

Wuhan Topule

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1361030-48-9, LDC1267Related Search:

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LDC1267

N-[4-[(6,7-dimethoxy-4-quinolyl)oxy]-3-fluoro-phenyl]-4-ethoxy-1-(4-fluoro-2-methyl-phenyl)pyrazole-3-carboxamide

N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]-3-fluorophenyl]-4-ethoxy-1-(4-fluoro-2-methylphenyl)-1H-pyrazole-3-carboxamide

CS-1641

LDC 1267;LDC-1267

1H-Pyrazole-3-carboxamide, N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-3-fluorophenyl]-4-ethoxy-1-(4-fluoro-2-methylphenyl)-

LDC1267 USP/EP/BP

N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluoro-2-methylphenyl)-1H-pyrazole-3-carboxamide

LDC 1267,LDC1267,Tyro3,Inhibitor,LDC-1267,inhibit,TAM Receptor,Axl,Mer

LDC1267, 10 mM in DMSO

TAM Receptor Kinase Inhibitor, LDC1267

1361030-48-9

136030-48-9

C30H26F2N4O5

Inhibitors