ChemicalBook > CAS DataBase List > 1426129-50-1 enantioMer

1426129-50-1 enantioMer

Product Name
1426129-50-1 enantioMer
CAS No.
153037-40-2
Chemical Name
1426129-50-1 enantioMer
Synonyms
LCZ-696 Impurity 66;Sacubitril Impurity 88;1426129-50-1 enantioMer;1,3-dimethyl-54-nitrosourea;Shakubatroxobin valsartan impurity 62;S-Tert-Butyl (1-([1,1'-biphenyl]-4-yl);LCZ696 valsartan + sacubitril Impurity 62;LCZ696（valsartan + sacubitril） Impurity(Hydrochloride);(2S)-2-(tert-Butoxycarbonylamino)-3-(biphenyl-4-yl)propanol;t-Butyl (S)-(1-([1,1'-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate
CBNumber
CB02736569
Molecular Formula
C20H25NO3
Formula Weight
327.42
MOL File
153037-40-2.mol
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1426129-50-1 enantioMer Property

storage temp. 
2-8°C
Appearance
White to off-white Solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific
Product number
7184DL
Product name
(S)-Tert-Butyl(1-([1,1'-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate
Packaging
100mg
Price
$120
Updated
2021/12/16
AK Scientific
Product number
7184DL
Product name
(S)-Tert-Butyl(1-([1,1'-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate
Packaging
250mg
Price
$174
Updated
2021/12/16
AK Scientific
Product number
7184DL
Product name
(S)-Tert-Butyl(1-([1,1'-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate
Packaging
1g
Price
$344
Updated
2021/12/16
Ambeed
Product number
A220993
Product name
(S)-tert-Butyl(1-([1,1'-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate
Purity
97%
Packaging
100mg
Price
$45
Updated
2021/12/16
Ambeed
Product number
A220993
Product name
(S)-tert-Butyl(1-([1,1'-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate
Purity
97%
Packaging
250mg
Price
$85
Updated
2021/12/16
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1426129-50-1 enantioMer Chemical Properties,Usage,Production

Uses

tert-Butyl (S)-(1-([1,1'-Biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate may be useful in the preparation of tetrazolylalkylaminomethylphosphonates as neutral endopeptidase inhibitors.

Synthesis

119273-61-9

153037-40-2

GENERAL METHODS: (S)-2-(tert-butoxycarbonylamino)-3-(biphenyl-4-yl)propanoic acid (2.65 g, 10 mmol) was dissolved in tetrahydrofuran (20 mL) under nitrogen protection and the solution was cooled down to 0°C. Subsequently, triethylamine (1.42 mL, 1.1 eq.) was added to the solution and a white precipitate was observed to form.After 0.25 h, the reaction mixture was filtered. The filtrate was slowly added dropwise to a solution of sodium borohydride (0.62 g, 1.5 eq.) in water (8 mL) at 0 °C. After 0.5 h, the reaction mixture was gradually warmed up to room temperature and stirring was continued for 2 h. The reaction mixture was then stirred for 2 h. The solution was then mixed with 2M salt (1.5 mL, 1.1 eq.) and the reaction was completed with 2M salt. Upon completion of the reaction, the reaction mixture was acidified to pH=2 with 2 M hydrochloric acid and then extracted with ethyl acetate. The organic layer was subsequently washed with saturated sodium bicarbonate solution, dried over anhydrous magnesium sulfate and concentrated under vacuum to afford the target product (S)-(1-([1,1'-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamic acid tert-butyl ester (1.88 g, 75% yield).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 2, p. 1208 - 1212

1426129-50-1 enantioMer Preparation Products And Raw materials

Raw materials

Preparation Products

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1426129-50-1 enantioMer Suppliers

China 49 India 1 United States 2 Global 52
Shanghai Topbiochem Technology Co., Ltd
Tel
+86-21-60341587
Fax
+86-21-61294319
Email
sales@topbiochem.com
Country
China
ProdList
6175
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58
Suzhou Sino Rare Chemical Co., Ltd.
Tel
0512-62857507
Fax
+86-512-62857507
Email
sales@sinorarechem.com
Country
China
ProdList
991
Advantage
58
Taizhou Tongxin Bio-Tech Co., Ltd
Tel
0523-86818997 18652728585
Email
sales@allyrise.com
Country
China
ProdList
2966
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60
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
18333
Advantage
56
Suzhou PengXu PharmaTech Co., Ltd.
Tel
15850786624
Email
sales@cqpharm.com
Country
China
ProdList
88
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
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60
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
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62
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
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58
Shenzhen SUNGENING Bio-Medical Co., Ltd.
Tel
0755-0755-28967200-8062 13631290199
Fax
0755-28967200
Email
wxf@sungening.com
Country
China
ProdList
9624
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60
Aikon International Limited
Tel
025-66061636 18013972705
Fax
(3)02557626880
Email
qqyang@aikonchem.com
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China
ProdList
15814
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153037-40-2, 1426129-50-1 enantioMerRelated Search:

Valsartan Valsartan Impurity 61 Valsartan Impurity 3 Valsartan Ethyl Ester USAWIVMZUYOXCF-UHFFFAOYSA-N Isoleucine Valsartan Valsartan Desvaleryl Impurity Valsartan n-Propyl 4-(2-Cyanophenyl)benzyl alcohol [1,1'-Biphenyl]-4-pentanoic acid, γ-amino-α-methyl-, ethyl ester, (Hydrochloride)(1:1), (αS,γS)- Valsartan Impurity 1 (2R,4S)-ethyl 5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoate Valsartan Impurity 32 LCZ-696 Impurity 60 N-NITROSO-DI-ISO-PROPYLAMINE Telmisartan Impurity 10 BOC-D-4,4'-BIPHENYLALANINE (R,E)-ethyl 5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoate

  • 1426129-50-1 enantioMer
  • (S)-tert-butyl (1-([1,1'-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbaMate
  • (2S)-2-(tert-Butoxycarbonylamino)-3-(biphenyl-4-yl)propanol
  • Carbamic acid, N-[(1S)-2-[1,1'-biphenyl]-4-yl-1-(hydroxymethyl)ethyl]-, 1,1-dimethylethyl ester
  • S-Tert-Butyl (1-([1,1'-biphenyl]-4-yl)
  • LCZ-696 Impurity 66
  • tert-Butyl (S)-(1-([1,1'-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate
  • Carbamic acid, [(1S)-2-[1,1'-biphenyl]-4-yl-1-(hydroxymethyl)ethyl]-,1,1-dimethylethyl ester
  • t-Butyl (S)-(1-([1,1'-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate
  • tert-Butyl(S)-(1-([1,1'-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate
  • 1,3-dimethyl-54-nitrosourea
  • Shakubatroxobin valsartan impurity 62
  • LCZ696（valsartan + sacubitril） Impurity(Hydrochloride)
  • LCZ696 valsartan + sacubitril Impurity 62
  • Sacubitril Impurity 88
  • 153037-40-2