(4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate
Uses- Product Name
- (4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate
- CAS No.
- 1146629-75-5
- Chemical Name
- (4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate
- Synonyms
- Lucitinib Impurity 10;(4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivaate;(4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate;(4-Chloro-7h-pyrrolo[2,3-d]pyrimidin-7-yl)metethyl pivlateala;(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl 2,2-dimethy...;(4-chloro-5,6-dihydro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate;(4-gas-7H-pyrrole and [2,3-inits mouth]Pyrimidine-7-yl) Methylvalproate;(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl 2,2-dimethylpropanoate;Propanoic acid, 2,2-dimethyl-, (4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl ester
- CBNumber
- CB02737021
- Molecular Formula
- C12H14ClN3O2
- Formula Weight
- 267.71
- MOL File
- 1146629-75-5.mol
(4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate Property
- Boiling point:
- 390.0±32.0 °C(Predicted)
- Density
- 1.30±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 2.81±0.30(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C12H14ClN3O2/c1-12(2,3)11(17)18-7-16-5-4-8-9(13)14-6-15-10(8)16/h4-6H,7H2,1-3H3
- InChIKey
- DTPDTZKIIYSQPO-UHFFFAOYSA-N
- SMILES
- C(OCN1C2C(C=C1)=C(Cl)N=CN=2)(=O)C(C)(C)C
- CAS DataBase Reference
- 1146629-75-5
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 2365AQ
- Product name
- 4-(1H-Pyrazol-4-yl)-7-((2-(trimethylsilyl)ethoxy)methyl-7H-pyrrolo[2,3-d]pyrimidine
- Packaging
- 25g
- Price
- $437.6
- Updated
- 2021/12/16
- Product number
- CD11346769
- Product name
- (4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methylpivalate
- Purity
- 95+%
- Packaging
- 100g
- Price
- $495
- Updated
- 2021/12/16
- Product number
- 1146629755
- Product name
- (4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methylpivalate
- Packaging
- 100g
- Price
- $530
- Updated
- 2021/12/16
- Product number
- A102895
- Product name
- (4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methylpivalate
- Purity
- 97%
- Packaging
- 250mg
- Price
- $8
- Updated
- 2021/12/16
- Product number
- A102895
- Product name
- (4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methylpivalate
- Purity
- 97%
- Packaging
- 1g
- Price
- $12
- Updated
- 2021/12/16
(4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate Chemical Properties,Usage,Production
Uses
(4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate can be used as a heterocyclic derivative for pharmaceutical synthesis.
Synthesis
18997-19-8
3680-69-1
1146629-75-5
4-Chloro-7H-pyrrolo[2,3-d]pyrimidine (25 g) and chloromethyl pivalate (27 g) were used as raw materials and potassium carbonate (27 g) and N,N-dimethylformamide (100 mL) were added to the reaction vessel. The reaction mixture was stirred at ambient temperature for 14 h. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, water (250 mL) was added to the mixture and stirring was continued for 2 hours. Subsequently, the reaction mixture was filtered, the filter cake was washed with water (50 mL) and finally dried under reduced pressure at 40 °C to 45 °C for 12 h to afford (4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate in 98.85% yield.
References
[1] Patent: WO2016/88094, 2016, A1. Location in patent: Page/Page column 10
[2] Organic Letters, 2009, vol. 11, # 9, p. 1999 - 2002
[3] Patent: US2010/190981, 2010, A1. Location in patent: Page/Page column 73-75
[4] Patent: CN107226814, 2017, A. Location in patent: Paragraph 0039-0040; 0042; 0044; 0046; 0048; 0050
[5] Patent: US2009/233903, 2009, A1. Location in patent: Page/Page column 67-68
(4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate manufacturers
- Product
- (4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate 1146629-75-5
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-20
- Product
- (4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate 1146629-75-5
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 ton
- Release date
- 2024-12-06
- Product
- (4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate 1146629-75-5
- Price
- US $1600.00/Kg/Bag
- Min. Order
- 1g/Bag
- Purity
- 99%
- Supply Ability
- 100kg/month
- Release date
- 2020-09-09