[4-(1H-Pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]methyl pivalate

Product Name: [4-(1H-Pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]methyl pivalate
CAS No.: 1146629-77-7
Chemical Name: [4-(1H-Pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]methyl pivalate
Synonyms: Baricitinib Impurity 81;Baricitinib Impurity 42;[4-(1H-Pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]methyl ...;4-(1H-Pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin070yl]methyl Pivalate;Methyl[4-(1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]pivalate;[4-(1H-Pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]methyl pivalate;4- (1H pyrazole-4-yl) -7H pyrrolo [2,3-d] pyrimidin-7-yl] methyl pentanoate;[4-(1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]methyl 2,2-dimethylpropanoate;[4-(1H-pyrazole-4-yl) -7h-pyrrorole [2,3-D] pyrimidine-7-yl] methyl tevalate ester;4- (1H-pyrazol-4-yl) -7H-pyrrolo [2,3-D] pyrimidine~7-yl] methyllevulinic acid ester
CBNumber: CB62737018
Molecular Formula: C15H17N5O2
Formula Weight: 299.33
MOL File: 1146629-77-7.mol

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[4-(1H-Pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]methyl pivalate Property

Boiling point:: 536.7±50.0 °C(Predicted)
Density: 1.33±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 10.76±0.50(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C15H17N5O2/c1-15(2,3)14(21)22-9-20-5-4-11-12(10-6-18-19-7-10)16-8-17-13(11)20/h4-8H,9H2,1-3H3,(H,18,19)
InChIKey: CPGIWDOJHYCMRW-UHFFFAOYSA-N
SMILES: C(OCN1C2C(C=C1)=C(C1=CNN=C1)N=CN=2)(=O)C(C)(C)C

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: P840545
Product name: [4-(1H-Pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin070yl]methylPivalate
Packaging: 50mg
Price: $45
Updated: 2021/12/16

AK Scientific

Product number: 7776DN
Product name: (4-(1H-Pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methylpivalate
Packaging: 1g
Price: $77
Updated: 2021/12/16

Ambeed

Product number: A186222
Product name: (4-(1H-Pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methylpivalate
Purity: 97%
Packaging: 250mg
Price: $6
Updated: 2021/12/16

Ambeed

Product number: A186222
Product name: (4-(1H-Pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methylpivalate
Purity: 97%
Packaging: 1g
Price: $13
Updated: 2021/12/16

Ambeed

Product number: A186222
Product name: (4-(1H-Pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methylpivalate
Purity: 97%
Packaging: 5g
Price: $46
Updated: 2021/12/16

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[4-(1H-Pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]methyl pivalate Chemical Properties,Usage,Production

Chemical Properties

Type of white solid

Synthesis

269410-08-4

1146629-75-5

1146629-77-7

The general procedure for the synthesis of (4-(1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate from 4-pyrazole boronic acid pinacol ester and (4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl tertiarylate was performed as follows: in a reaction vessel, add (4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl) methyl 2,2-dimethylpropionate (10 g), water (50 mL) and potassium carbonate (15.5 g) and stirred at room temperature. Subsequently, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (8.7 g), 1,4-dioxane (100 mL) and tetrakis(triphenylphosphine)palladium(0) (0.08 g) were added. The reaction mixture was heated to 80°C to 85°C and stirred at this temperature for 14 hours. The reaction process was monitored by thin layer chromatography. Upon completion of the reaction, ethyl acetate (100 mL) was added to the mixture and stirring was continued for 1 hour. It was then filtered through Hyflo and washed with ethyl acetate (40 mL). The organic layer was separated and concentrated under reduced pressure to afford the target product [4-(1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]methyl pivalate in 82.27% yield.

References

[1] Patent: WO2016/88094, 2016, A1. Location in patent: Page/Page column 10

[4-(1H-Pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]methyl pivalate Preparation Products And Raw materials

Raw materials

Preparation Products

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[4-(1H-Pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]methyl pivalate Suppliers

China 132 India 2 United States 3 Global 137

Anqing Xinheyuan Pharmaceutical Technology Co., Ltd

Tel: 18915922978 15270619650
Email: xiang.ru@synovent.cn
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PharmaHands (Taizhou) Co., Ltd.

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shanghai Rainbow MediTech.Co.Ltd.

Tel: 021-64968085,64968086-5815,5812; 13472757003
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Jinan Chenghui Shuangda biological Co., LTD

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EnliPharma Technology Co., Ltd

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Bide Pharmatech Ltd.

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Zhengzhou HongSheng Pharmaceutical Co., Ltd.

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Shandong Zhongke Taidou Chemical Co., Ltd.

Tel: 0531-88682301 18595278760
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Shanghai KunRaise Chemical Technology Co., Ltd

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FarmaSino Pharmaceuticals (Anhui) Co.,Ltd.

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View Lastest Price from [4-(1H-Pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]methyl pivalate manufacturers

ShenZhen H&D Pharmaceutical Technology Co., LTD

Product: Ruxolitinib Impurity 21 1146629-77-7
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 98%
Supply Ability: 500mg
Release date: 2024-08-06

Shaanxi Dideu New Materials Co. Ltd

Product: [4-(1H-Pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]methyl pivalate 1146629-77-7
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2024-11-14

Hebei Chuanghai Biotechnology Co,.LTD

Product: [4-(1H-pyrazole-4-yl) -7h-pyrrorole [2,3-D] pyrimidine-7-yl] methyl tevalate ester 1146629-77-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99.%
Supply Ability: 50 ton
Release date: 2024-08-23

1146629-77-7, [4-(1H-Pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]methyl pivalateRelated Search:

[4-[1-(1-ethoxyethyl)-1H-pyrazol-4-yl]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]methyl (4-(1-(3-(cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate 3-(cyanomethyl)-3-[4-(7-[2-(trimethylsilyl)ethoxy]methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]cyclobutylmethyl methanesulfonate 4-CHLORO-7-((2-(TRIMETHYLSILYL)ETHOXY)METHYL)-7H-PYRROLO[2,3-D]PYRIMIDINE (4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate 4-(1H-Pyrazol-4-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine

[4-(1H-Pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]methyl pivalate

[4-(1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]methyl 2,2-dimethylpropanoate

Propanoic acid, 2,2-dimethyl-, [4-(1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]methyl ester

4-(1H-Pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin070yl]methyl Pivalate

[4-(1H-pyrazole-4-yl) -7h-pyrrorole [2,3-D] pyrimidine-7-yl] methyl tevalate ester

[4-(1H-Pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]methyl ...

4- (1H pyrazole-4-yl) -7H pyrrolo [2,3-d] pyrimidin-7-yl] methyl pentanoate

4- (1H-pyrazol-4-yl) -7H-pyrrolo [2,3-D] pyrimidine~7-yl] methyllevulinic acid ester

Baricitinib Impurity 42

Baricitinib Impurity 81

2-(3-(4-(6-amino-5-formylpyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(ethylsulfonyl)azetidin-3-yl)acetonitrile

Methyl[4-(1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]pivalate

1146629-77-7