OTS964
- Product Name
- OTS964
- CAS No.
- 1338545-07-5
- Chemical Name
- OTS964
- Synonyms
- OTS964;CS-2531;OTS964 HCl;OTS964; OTS 964;OTS964+OTS964 HCl;OTS964 HYDROCHLORIDE;(R)-9-(4-(1-(dimethylamino)propan-2-yl)phenyl)-8-hydroxy-6-methylthieno[2,3-c]quinolin-4(5H)-one;(R)-9-[4-[1-(Dimethylamino)propan-2-yl]phenyl]-8-hydroxy-6-methylthieno[2,3-c]quinolin-4(5H)-one Hydrochloride
- CBNumber
- CB02737339
- Molecular Formula
- C23H24N2O2S
- Formula Weight
- 392.51386
- MOL File
- 1338545-07-5.mol
OTS964 Property
- storage temp.
- Store at -20°C
- solubility
- ≥88.6 mg/mL in DMSO; ≥2.15 mg/mL in EtOH with gentle warming and ultrasonic; ≥2.1 mg/mL in H2O with gentle warming and ultrasonic
- form
- crystalline solid
Safety
- HS Code
- 2934999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 17052
- Product name
- OTS964 (hydrochloride)
- Packaging
- 1mg
- Price
- $92
- Updated
- 2024/03/01
- Product number
- 17052
- Product name
- OTS964 (hydrochloride)
- Packaging
- 5mg
- Price
- $168
- Updated
- 2024/03/01
- Product number
- 17052
- Product name
- OTS964 (hydrochloride)
- Packaging
- 500μg
- Price
- $49
- Updated
- 2024/03/01
- Product number
- O712970
- Product name
- OTS964
- Packaging
- 25mg
- Price
- $1175
- Updated
- 2021/12/16
- Product number
- O712970
- Product name
- OTS964
- Packaging
- 10mg
- Price
- $590
- Updated
- 2021/12/16
OTS964 Chemical Properties,Usage,Production
Description
OTS964 is an inhibitor of lymphokine-activated killer T cell-originated protein kinase (TOPK; IC50 = 28 nM). It specifically blocks cytokinesis, leading to apoptosis, in a broad range of cancer cells. OTS964 induces apoptosis of human lung cancer cells in mouse xenografts.
Uses
OTS 964 works through cytokinesis and is an effective TOPK inhibitor which has been shown to cause tumor suppression in xenografts of human cancer.
References
1. matsuo y, park jh2, miyamoto t, et al. topk inhibitor induces complete tumor regression in xenograft models of human cancer through inhibition of cytokinesis. ci transl med. 2014 oct 22;6(259):259ra145.
OTS964 Preparation Products And Raw materials
Raw materials
Preparation Products
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