Propanoic acid, 2-cyano-
- Product Name
- Propanoic acid, 2-cyano-
- CAS No.
- 632-07-5
- Chemical Name
- Propanoic acid, 2-cyano-
- Synonyms
- NSC 528442;Propanoic acid, 2-cyano-;alpha-Cyanopropionic acid;2-cyano-2-methylacetic acid
- CBNumber
- CB02739090
- Molecular Formula
- C4H5NO2
- Formula Weight
- 99.09
- MOL File
- 632-07-5.mol
Propanoic acid, 2-cyano- Property
- Melting point:
- 35°C
- Boiling point:
- 185.54°C (rough estimate)
- Density
- 1.1400
- refractive index
- 1.4166 (estimate)
- storage temp.
- 2-8°C
- form
- liquid
- pka
- 2.57±0.10(Predicted)
- color
- Pale yellow
Safety
- HS Code
- 2926907090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 7752BA
- Product name
- 2-Cyanopropanoicacid
- Packaging
- 250mg
- Price
- $494
- Updated
- 2021/12/16
- Product number
- 7752BA
- Product name
- 2-Cyanopropanoicacid
- Packaging
- 5g
- Price
- $1464
- Updated
- 2021/12/16
- Product number
- 7752BA
- Product name
- 2-Cyanopropanoicacid
- Packaging
- 10g
- Price
- $2560
- Updated
- 2021/12/16
- Product number
- A134730
- Product name
- 2-Cyanopropanoicacid
- Purity
- 97%
- Packaging
- 5g
- Price
- $737
- Updated
- 2021/12/16
- Product number
- CD13008003
- Product name
- 2-Cyanopropanoicacid
- Purity
- 97%
- Packaging
- 5g
- Price
- $743
- Updated
- 2021/12/16
Propanoic acid, 2-cyano- Chemical Properties,Usage,Production
Synthesis
1572-99-2
632-07-5
General procedure for the synthesis of 2-cyanopropionic acid from ethyl 2-cyanopropionate: ethyl 2-cyanopropionate (1.0 g, 7.87 mmol), methanol (4 mL), and water (4 mL) were added to a reaction flask. After cooling the reaction mixture to 0°C, potassium hydroxide (882 mg, 16 mmol) was slowly added. Subsequently, the reaction system was warmed to 40 °C with continuous stirring for 2 hours. Upon completion of the reaction, methanol was removed by concentration under reduced pressure and the pH was adjusted to 5 with 1 N hydrochloric acid. extraction was carried out with ethyl acetate (50 mL x 2) and the organic phases were combined. The organic phase was washed with saturated brine, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give 2-cyanopropionic acid (660 mg, 85% yield) as a purple oil. The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 13.59 (br, 1H), 4.03 (q, J=7.2 Hz, 1H), 1.41 (d, J=7.2 Hz, 3H).
References
[1] Angewandte Chemie - International Edition, 2015, vol. 54, # 33, p. 9668 - 9672
[2] Angew. Chem., 2015, vol. 127, # 33, p. 9804 - 9808,5
[3] Angewandte Chemie - International Edition, 2008, vol. 47, # 18, p. 3381 - 3384
[4] Patent: US2018/282328, 2018, A1. Location in patent: Paragraph 0859; 0860
[5] Chemische Berichte, 1930, vol. 63, p. 2385
Propanoic acid, 2-cyano- Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Propanoic acid, 2-cyano- manufacturers
- Product
- Propanoic acid, 2-cyano- 632-07-5
- Price
- US $8.00/KG
- Min. Order
- 1KG
- Purity
- >98% HPLC
- Supply Ability
- 20 tons
- Release date
- 2020-02-17