Cravatt Reagent

Product Name: Cravatt Reagent
CAS No.: 1438416-21-7
Chemical Name: Cravatt Reagent
Synonyms: KT195;KT109;HT-01;KT172;MJN110;Cravatt Reagent;MJN110 >=98% (HPLC);BEADRWVIFHOSGN-UHFFFAOYSA-N;MAGL,MJN 110,Inhibitor,Monoacylglycerol lipase,MJN110,MJN-110,inhibit;2,5-dioxopyrrolidin-1-yl 4-(bis(4-chlorophenyl)methyl)piperazine-1-carboxylate
CBNumber: CB02750604
Molecular Formula: C22H21Cl2N3O4
Formula Weight: 462.33
MOL File: 1438416-21-7.mol

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Cravatt Reagent Property

Boiling point:: 561.5±60.0 °C(Predicted)
Density: 1.47±0.1 g/cm3(Predicted)
storage temp.: room temp
solubility: DMSO: soluble20mg/mL, clear
pka: 5.07±0.10(Predicted)
form: powder
color: white to beige

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Safety

Hazard Codes: Xn,N
Risk Statements: 22-50/53
Safety Statements: 26-60-61
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0872
Product name: MJN110
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $120
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0872
Product name: MJN110
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $194.8
Updated: 2024/03/01

Cayman Chemical

Product number: 17583
Product name: MJN110
Purity: ≥95%
Packaging: 5mg
Price: $82
Updated: 2024/03/01

Cayman Chemical

Product number: 17583
Product name: MJN110
Purity: ≥95%
Packaging: 100mg
Price: $808
Updated: 2024/03/01

Cayman Chemical

Product number: 17583
Product name: MJN110
Purity: ≥95%
Packaging: 1mg
Price: $25
Updated: 2021/12/16

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Cravatt Reagent Chemical Properties,Usage,Production

Uses

Endocannabinoids such as 2-arachidonoyl glycerol (2-AG; ) and arachidonoyl ethanolamide (AEA; ) are biologically active lipids that are involved in a number of synaptic processes including activation of cannabinoid receptors. Monoacylglycerol lipase (MAGL) is a serine hydrolase responsible for the hydrolysis of 2-AG to arachidonic acid and glycerol, thus terminating its biological function. MJN110 is an N-hydroxysuccinimidyl carbamate that inhibits MAGL (IC50 = 9.1 nM) and to a lesser extent ABHD6 with potent selectivity over FAAH (IC50 > 10 μM) and other brain serine hydrolases. It can inhibit 2-AG hydrolysis (IC50 = 2.1 nM) with no effect on AEA hydrolysis up to 50 μM. At 5 mg/kg, MJN110 has been shown to alleviate mechanical allodynia in a rat model of diabetic neuropathy.[Cayman Chemical]

Uses

MJN110 has been used as a monoacylglycerol lipase (MAGL) inhibitor to study its effect on aggressive grooming in rats. It has also been used to inhibit lipid droplet formation.

Biochem/physiol Actions

MJN110 is a potent selective inhibitor of MAGL, the enzyme predominantly responsible for the degradation of the endocannabinoid 2-arachidonoylglycerol (2-AG) with >10,000 selectivity over FAAH, the hydrolase that degrades the endocannabinoid anandamide (AEA). MJN110 inhibits rat, mouse and human MAGL with IC50 values ranging from < 100 nM in rat to an IC50 of ~1 nM with 10- and 100-fold selectivity over closely related ABHD6, a serine hydrolase that acts as an alternative hydrolase of 2-AG, and LYPLA1/2 in human PC3 cells. MJN110 showed potent anti-hyperalgesic activity in a rat model of diabetic neuropathy, showing a therapeutic potential for treating diabetes chronic pain.

Cravatt Reagent Preparation Products And Raw materials

Raw materials

Preparation Products

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Cravatt Reagent Suppliers

China 32 United Kingdom 1 United States 6 USA 1 Global 40

Sigma-Aldrich

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Pharmacodia (Beijing) Co.,Ltd

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Fax: +86-10-82826195
Email: sales@pharmacodia.com
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Shanghai EFE Biological Technology Co., Ltd.

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Shanghai Chaolan Chemical Technology Center

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Amadis Chemical Company Limited

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Lynnchem

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Novachemistry

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Shanghai Yu Ben Biotechnology Co., Ltd.

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HANGZHOU CLAP TECHNOLOGY CO.,LTD

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DC Chemicals

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1438416-21-7, Cravatt ReagentRelated Search:

2,5-dioxopyrrolidin-1-yl 4-(bis(4-chlorophenyl)methyl)piperazine-1-carboxylate

Cravatt Reagent

MJN110

(2-Benzylpiperidin-1-yl)(4-(2′-methoxy-[1,1′-biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl)methanone

KT172

HT-01

N-(5-(3-(5,5-Difluoro-7,9-dimethyl-5H-4l4,5l4-dipyrrolo[1,2-c:2′,1′-f][1,3,2]diazaborinin-3-yl)propanamido)pentyl)-N-phenethyl-4-(4-(trifluoromethoxy)phenyl)-1H-1,2,3-triazole-1-carboxamide

KT195

(4-([1,1′-Biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl)(2-benzylpiperidin-1-yl)methanone

KT109

BEADRWVIFHOSGN-UHFFFAOYSA-N

1-Piperazinecarboxylic acid, 4-[bis(4-chlorophenyl)methyl]-, 2,5-dioxo-1-pyrrolidinyl ester

MJN110 >=98% (HPLC)

MAGL,MJN 110,Inhibitor,Monoacylglycerol lipase,MJN110,MJN-110,inhibit

1438416-21-7