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Cravatt Reagent

Product Name
Cravatt Reagent
CAS No.
1438416-21-7
Chemical Name
Cravatt Reagent
Synonyms
KT195;KT109;HT-01;KT172;MJN110;Cravatt Reagent;MJN110 >=98% (HPLC);MJN110, 10 mM in DMSO;BEADRWVIFHOSGN-UHFFFAOYSA-N;MAGL,MJN 110,Inhibitor,Monoacylglycerol lipase,MJN110,MJN-110,inhibit
CBNumber
CB02750604
Molecular Formula
C22H21Cl2N3O4
Formula Weight
462.33
MOL File
1438416-21-7.mol
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Cravatt Reagent Property

Boiling point:
561.5±60.0 °C(Predicted)
Density 
1.47±0.1 g/cm3(Predicted)
storage temp. 
room temp
solubility 
DMSO: soluble20mg/mL, clear
form 
powder
pka
5.07±0.10(Predicted)
color 
white to beige
InChI
1S/C22H21Cl2N3O4/c23-17-5-1-15(2-6-17)21(16-3-7-18(24)8-4-16)25-11-13-26(14-12-25)22(30)31-27-19(28)9-10-20(27)29/h1-8,21H,9-14H2
InChIKey
BEADRWVIFHOSGN-UHFFFAOYSA-N
SMILES
O=C(ON1C(CCC1=O)=O)N2CCN(C(C3=CC=C(Cl)C=C3)C4=CC=C(Cl)C=C4)CC2
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Safety

Hazard Codes 
Xn,N
Risk Statements 
22-50/53
Safety Statements 
26-60-61
WGK Germany 
3
Storage Class
11 - Combustible Solids
Hazard Classifications
Acute Tox. 4 Oral
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0872
Product name
MJN110
Purity
≥98% (HPLC)
Packaging
5mg
Price
$86.1
Updated
2025/07/31
Sigma-Aldrich
Product number
SML0872
Product name
MJN110
Purity
≥98% (HPLC)
Packaging
25mg
Price
$250.5
Updated
2025/07/31
Cayman Chemical
Product number
17583
Product name
MJN110
Purity
≥95%
Packaging
5mg
Price
$82
Updated
2024/03/01
Cayman Chemical
Product number
17583
Product name
MJN110
Purity
≥95%
Packaging
100mg
Price
$808
Updated
2024/03/01
Cayman Chemical
Product number
17583
Product name
MJN110
Purity
≥95%
Packaging
1mg
Price
$25
Updated
2021/12/16
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Cravatt Reagent Chemical Properties,Usage,Production

Uses

Endocannabinoids such as 2-arachidonoyl glycerol (2-AG; ) and arachidonoyl ethanolamide (AEA; ) are biologically active lipids that are involved in a number of synaptic processes including activation of cannabinoid receptors. Monoacylglycerol lipase (MAGL) is a serine hydrolase responsible for the hydrolysis of 2-AG to arachidonic acid and glycerol, thus terminating its biological function. MJN110 is an N-hydroxysuccinimidyl carbamate that inhibits MAGL (IC50 = 9.1 nM) and to a lesser extent ABHD6 with potent selectivity over FAAH (IC50 > 10 μM) and other brain serine hydrolases. It can inhibit 2-AG hydrolysis (IC50 = 2.1 nM) with no effect on AEA hydrolysis up to 50 μM. At 5 mg/kg, MJN110 has been shown to alleviate mechanical allodynia in a rat model of diabetic neuropathy.[Cayman Chemical]

Uses

MJN110 has been used as a monoacylglycerol lipase (MAGL) inhibitor to study its effect on aggressive grooming in rats. It has also been used to inhibit lipid droplet formation.

Biochem/physiol Actions

MJN110 is a potent selective inhibitor of MAGL, the enzyme predominantly responsible for the degradation of the endocannabinoid 2-arachidonoylglycerol (2-AG) with >10,000 selectivity over FAAH, the hydrolase that degrades the endocannabinoid anandamide (AEA). MJN110 inhibits rat, mouse and human MAGL with IC50 values ranging from < 100 nM in rat to an IC50 of ~1 nM with 10- and 100-fold selectivity over closely related ABHD6, a serine hydrolase that acts as an alternative hydrolase of 2-AG, and LYPLA1/2 in human PC3 cells. MJN110 showed potent anti-hyperalgesic activity in a rat model of diabetic neuropathy, showing a therapeutic potential for treating diabetes chronic pain.

in vivo

MJN110 (i.p.; 0.0818 mg/kg; twice daily for 5.5 days) reverses chronic constriction injury (CCI)-induced mechanical allodynia and thermal hyperalgesia in a dose-dependent manner. The respective ED50 value (95% confidence limits) is 0.430 (0.233-0.793) mg/kg[1].

Animal Model:Male C57BL/6J mice ranged from 18 to 35 g[1]
Dosage:0.0818 mg/kg
Administration:I.p.; twice daily for 5.5 days
Result:Reversed CCI-induced mechanical allodynia and thermal hyperalgesia in a dose-dependent manner.

Cravatt Reagent Preparation Products And Raw materials

Raw materials

Preparation Products

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Cravatt Reagent Suppliers

China 50 United Kingdom 1 United States 7 USA 1 Global 59
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51395
Advantage
80
Shanghai Beckham Medical Technology Co., Ltd
Tel
13816613772
Fax
QQ: 12922499
Email
huahero21@sina.com
Country
China
ProdList
2495
Advantage
55
Pharmacodia (Beijing) Co.,Ltd
Tel
+86-400-851-9921
Fax
+86-10-82826195
Email
sales@pharmacodia.com
Country
China
ProdList
2317
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Lynnchem
Tel
86-(0)29-85992781 17792393971
Email
info@lynnchem.com
Country
China
ProdList
4587
Advantage
58
Novachemistry
Tel
44-20819178-90 02081917890
Fax
(0)2080432064
Email
info@novachemistry.com
Country
United Kingdom
ProdList
4381
Advantage
58
Shanghai Yu Ben Biotechnology Co., Ltd.
Tel
021-61350663 15502154572
Fax
-
Email
1639466865@qq.com
Country
China
ProdList
499
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32470
Advantage
58

1438416-21-7, Cravatt ReagentRelated Search:


  • 2,5-dioxopyrrolidin-1-yl 4-(bis(4-chlorophenyl)methyl)piperazine-1-carboxylate
  • Cravatt Reagent
  • MJN110
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  • KT172
  • HT-01
  • N-(5-(3-(5,5-Difluoro-7,9-dimethyl-5H-4l4,5l4-dipyrrolo[1,2-c:2′,1′-f][1,3,2]diazaborinin-3-yl)propanamido)pentyl)-N-phenethyl-4-(4-(trifluoromethoxy)phenyl)-1H-1,2,3-triazole-1-carboxamide
  • KT195
  • (4-([1,1′-Biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl)(2-benzylpiperidin-1-yl)methanone
  • KT109
  • BEADRWVIFHOSGN-UHFFFAOYSA-N
  • 1-Piperazinecarboxylic acid, 4-[bis(4-chlorophenyl)methyl]-, 2,5-dioxo-1-pyrrolidinyl ester
  • MJN110 >=98% (HPLC)
  • MAGL,MJN 110,Inhibitor,Monoacylglycerol lipase,MJN110,MJN-110,inhibit
  • MJN110, 10 mM in DMSO
  • 1438416-21-7