3,5-dichloro-4-formylbenzoic acid

Product Name: 3,5-dichloro-4-formylbenzoic acid
CAS No.: 153203-80-6
Chemical Name: 3,5-dichloro-4-formylbenzoic acid
Synonyms: Lusutrombopag Impurity 8;Lusutrombopag Impurity 4;3,5-dichloro-4-formylbenzoic acid;Ethane,1-bromo-2-(5-methoxyethoxy)-;Benzoic acid, 3,5-dichloro-4-formyl-
CBNumber: CB02756510
Molecular Formula: C8H4Cl2O3
Formula Weight: 219.02
MOL File: 153203-80-6.mol

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3,5-dichloro-4-formylbenzoic acid Property

Boiling point:: 366.7±42.0 °C(Predicted)
Density: 1.592±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: DMSO (Slightly), Ethyl Acetate (Slightly)
form: Solid
pka: 3.04±0.10(Predicted)
color: White to Pale Beige
InChI: InChI=1S/C8H4Cl2O3/c9-6-1-4(8(12)13)2-7(10)5(6)3-11/h1-3H,(H,12,13)
InChIKey: KNZHVHRJCNWQKI-UHFFFAOYSA-N
SMILES: C(O)(=O)C1=CC(Cl)=C(C=O)C(Cl)=C1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: L474988
Product name: 3,5-Dichloro-4-formylbenzoicAcid
Packaging: 100mg
Price: $70
Updated: 2021/12/16

AK Scientific

Product number: 6409CY
Product name: 3,5-Dichloro-4-formylbenzoicacid
Packaging: 250mg
Price: $88
Updated: 2021/12/16

Ambeed

Product number: A106758
Product name: 3,5-Dichloro-4-formylbenzoicacid
Purity: 97%
Packaging: 100mg
Price: $15
Updated: 2021/12/16

Ambeed

Product number: A106758
Product name: 3,5-Dichloro-4-formylbenzoicacid
Purity: 97%
Packaging: 250mg
Price: $21
Updated: 2021/12/16

Ambeed

Product number: A106758
Product name: 3,5-Dichloro-4-formylbenzoicacid
Purity: 97%
Packaging: 1g
Price: $50
Updated: 2021/12/16

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3,5-dichloro-4-formylbenzoic acid Chemical Properties,Usage,Production

Synthesis

51-36-5

68-12-2

153203-80-6

To the reactor was added 3,5-dichlorobenzoic acid (190 g, 1.0 mmol), which was dissolved with anhydrous THF (1 L) and cooled to -78 °C. Under the condition of maintaining the reaction temperature, n-butyllithium (2.5 M, 0.5 L) was slowly added dropwise. Subsequently, N,N-dimethylformamide (95 g, 1.3 mmol) was added slowly and the titration process lasted for 2 hours. The reaction mixture was slowly warmed up to room temperature until the feedstock completely disappeared. After completion of the reaction, the reaction was quenched with a half-saturated ammonium chloride solution and the organic phase was extracted with ethyl acetate. The organic phase was concentrated to give a white solid. Finally, purification by pulping using mixed petroleum ether/ethyl acetate solvent gave 3,5-dichloro-4-formylbenzoic acid (179 g, 82% yield).

References

[1] Patent: CN106565625, 2017, A. Location in patent: Paragraph 0073-0074
[2] Patent: CN104341316, 2017, B. Location in patent: Paragraph 0379; 0381; 0382

3,5-dichloro-4-formylbenzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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3,5-dichloro-4-formylbenzoic acid Suppliers

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View Lastest Price from 3,5-dichloro-4-formylbenzoic acid manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 3,5-dichloro-4-formylbenzoic acid 153203-80-6
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2025-09-23

Henan Aochuang Chemical Co.,Ltd.

Product: 3,5-dichloro-4-formylbenzoic acid 153203-80-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-26

Shaanxi Dideu New Materials Co. Ltd

Product: 3,5-dichloro-4-formylbenzoic acid 153203-80-6
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 10000kg
Release date: 2024-11-09

153203-80-6, 3,5-dichloro-4-formylbenzoic acidRelated Search:

Benzoic acid (E)-3,5-dichloro-4-(3-ethoxy-2-methyl-3-oxoprop-1-enyl)benzoic acid (S)-4-(3-(1-(hexyloxy)ethyl)-2-methoxyphenyl)thiazol-2-amine 4-Aminobenzoic acid

3,5-dichloro-4-formylbenzoic acid

Benzoic acid, 3,5-dichloro-4-formyl-

Lusutrombopag Impurity 8

Ethane,1-bromo-2-(5-methoxyethoxy)-

Lusutrombopag Impurity 4

153203-80-6

C8H4Cl2O3