ChemicalBook > CAS DataBase List > Pramipexole impurity 7

Pramipexole impurity 7

Product Name
Pramipexole impurity 7
CAS No.
106092-09-5
Chemical Name
Pramipexole impurity 7
Synonyms
Pramipexole-1;PraMipexole IMpurity A;PraMipexole IMpurity C;Pramipexole impurity I;Pramipexole Impurity A1;Paramipexole Impurity-A;Pramipexole Intermediate 1;pramipexole impurities1162;(S)-N-Despropyl PraMipexole;PraMipexole Related CoMpound A
CBNumber
CB0276708
Molecular Formula
C7H11N3S
Formula Weight
169.25
MOL File
106092-09-5.mol
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Pramipexole impurity 7 Property

Melting point:
222-224°C
Boiling point:
359.0±42.0 °C(Predicted)
Density 
1.313±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly, Heated)
form 
Solid
pka
9.18±0.20(Predicted)
color 
White to Pale Beige
optical activity
Consistent with structure
Stability:
Light Sensitive
InChI
InChI=1/C7H11N3S/c8-4-1-2-5-6(3-4)11-7(9)10-5/h4H,1-3,8H2,(H2,9,10)/t4-/s3
InChIKey
DRRYZHHKWSHHFT-BYPYZUCNSA-N
SMILES
NC1SC2C[C@@H](N)CCC=2N=1 |&1:5,r|
CAS DataBase Reference
106092-09-5(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26
WGK Germany 
3
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR2010
Product name
Pramipexole Related Compound A
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
50mg
Price
$631.75
Updated
2025/07/31
Sigma-Aldrich
Product number
757381
Product name
(S)-(?)-2,6-Diamino-4,5,6,7-tetrahydrobenzothiazole
Purity
97%
Packaging
1g
Price
$85.6
Updated
2023/06/20
TCI Chemical
Product number
D4337
Product name
(S)-(-)-2,6-Diamino-4,5,6,7-tetrahydrobenzothiazole
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$67
Updated
2025/07/31
TCI Chemical
Product number
D4337
Product name
(S)-(-)-2,6-Diamino-4,5,6,7-tetrahydrobenzothiazole
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$263
Updated
2025/07/31
Sigma-Aldrich
Product number
1553768
Product name
Pramipexole Related Compound A
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
15mg
Price
$1300
Updated
2025/07/31
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Pramipexole impurity 7 Chemical Properties,Usage,Production

Chemical Properties

Pale Beige Solid

Uses

(S)-Pramipexole intermediate as dopamine autoreceptor agonist.

Uses

(S)-N-Despropyl Pramipexole (Pramipexole EP Impurity A; Pramipexole BP Impurity A; Pramipexole USP Related Compound A) is a (S)-Pramipexole (P700755) intermediate as dopamine autoreceptor agonist.

Uses

(S)-N-Despropyl Pramipexole is a (S)-Pramipexole (P700745) intermediate as dopamine autoreceptor agonist.

Synthesis

106006-83-1

106092-09-5

General procedure for the synthesis of (S)-2,6-diamino-4,5,6,7-tetrahydrobenzothiazole from 2,6-diamino-4,5,6,7-tetrahydrobenzothiazole: First, 33.8 g of 2,6-diamino-4,5,6,7-tetrahydrobenzothiazole was mixed with 500 mL of water, followed by the addition of 30.0 g of L-(+)-tartaric acid. The reaction mixture was heated to 75°C and stirred for 1 hour. Thereafter, it was cooled to room temperature and stirring was continued for 24 hours. After completion of the reaction, filtration was carried out, the precipitate was washed with water and dried under vacuum at 55°C to 65°C and -0.01 MPa to -0.1 MPa for 8-12 hours to afford 35.1 g of (S)-2,6-diamino-4,5,6,7-tetrahydrobenzothiazolium di-L-(+)-tartrate as crude product with an enantiomeric content of 2.53% (by chiral-HPLC determination). The entire crude product was redissolved in 500 mL of water, heated to 75°C and held for 1 hour, then cooled to room temperature and stirred for 24 hours. It was filtered again, washed with water and dried under the same vacuum conditions for 8-12 hours to give 26.9 g of (S)-2,6-diamino-4,5,6,7-tetrahydrobenzothiazolyl di-L-(+)-tartrate with enantiomeric content reduced to 0.08%. Finally, the entire product was dissolved in a mixture of 200 mL of water and 40 mL of hydrochloric acid and stirred until completely dissolved. Subsequently, 35 drops of aqueous potassium hydroxide solution (mass percent is the ratio of potassium hydroxide to the total mass of the solution) were added to neutralize. The reaction mixture was cooled to room temperature and stirred for 1 h. The reaction mixture was filtered, the precipitate was washed with water and dried under vacuum at 55°C to 65°C and -0.01 MPa to -0.1 MPa for 8-12 h. The final product was 9.43 g of (S)-2,6-diamino-4,5,6,7-tetrahydrobenzothiazole in a yield of 27.9% and enantiomeric content of 0.08%.

References

[1] Journal of Medicinal Chemistry, 2015, vol. 58, # 14, p. 5501 - 5521
[2] Patent: CN108084115, 2018, A. Location in patent: Paragraph 0086; 0089
[3] Journal of Medicinal Chemistry, 1987, vol. 30, # 3, p. 494 - 498
[4] Patent: WO2011/21214, 2011, A2
[5] Investigational New Drugs, 2010, vol. 28, # 4, p. 454 - 465

Pramipexole impurity 7 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Pramipexole impurity 7 manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
(S)-4,5,6,7-Tetrahydro-2,6-benzothiazolediamine 106092-09-5
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-20
Hangzhou ICH Biofarm Co., Ltd
Product
(S)-4,5,6,7-Tetrahydro-2,6-benzothiazolediamine 106092-09-5
Price
US $0.00/kg
Min. Order
1kg
Purity
99.0%min
Supply Ability
5MT
Release date
2023-06-14
Zhuozhou Wenxi import and Export Co., Ltd
Product
(S)-4,5,6,7-Tetrahydro-2,6-benzothiazolediamine 106092-09-5
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11

106092-09-5, Pramipexole impurity 7Related Search:

Iminodiacetonitrile Diaminomaleonitrile 2-Mercaptobenzothiazole AMINOACETONITRILE HYDROGEN SULFATE Iminodiacetic acid 4,4'-Methylenedianiline Benzothiazole 2,2'-Dithiobis(benzothiazole) 2,6-diamino-4,5,6,7-tetrahydrobenzo[d]thiazol-7-ol Pemetrexed Impurity 1 Dabigatran Impurity 8 PeMetrexed EP IMpurity A Desethyl Dabigatran Etexilate PeMetrexed IMpurity D (R)-Pramipexole N6-propyl-3a,4,5,6,7,7a-hexahydrobenzo[d]thiazole-2,6-diamine Pramipexole EP Impurity E N-(Aminothioxomethyl)-5-oxo-1-propyl-2-pyrrolidineacetamide

  • (6S)-4,5,6,7-TETRAHYDRO-1,3-BENZOTHIAZOL-2,6-DIAMINE
  • (6S)-4,5,6,7-TETRAHYDRO-1,3-BENZOTHIAZOLE-2,6-DIAMINE
  • S-(-)-2,6-Diamino-4,5,6,7-tetrahydrobenzothiazole (6S)-2,6-Diamino-4,5,6,7-tetrahydrobenzothiazole
  • (6S)-2,6-Diamino-4,5,6,7-tetrahydrobenzothiazole
  • (-)-2,6-DIAMINO-4,5,6,7-TETRA-HYDROXYBENZOTHIAZOL
  • S-(-)-2,6-Diamino-4,5,6,7-tetrahydro-2,6-benzothiazole
  • (S)-2-Amino-4,5,6,7-tetrahydro-6-aminobenzothiazole
  • (S)-(-)-2,6-Diamino-4,5,6,7-tetrahydrobenzothiazole, 99%, ee: 99%
  • Pramipexole Impurity 1(Pramipexole EP Impurity A)
  • (s)-4,5,6,7-tetrahydro-2,6-benzothiazolediamine
  • (S)-4,5,6,7-TETRAHYDROBENZO[D]THIAZOLE-2,6-DIAMINE
  • (S)-4,5,6,7-TETRAHYDRO-BENZOTHIAZOLE-2,6-DIAMINE
  • S-(-)-2,6-Diamino-4,5,6,7-tetrahydrobenzothiazole
  • (-)-2,6-diamino-4,5,6,7-tetrahydroben thiazole
  • (-)-(6S)-2,6-Diamino-4,5,6-tetrahydrobenzothiazole
  • S(-) 2-Amino-6-amino-4,5,6,7-tetrahydro benzothiazole
  • Praxsol Hydrochloride Impurity A
  • 4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine
  • Pramipexole Intermediate 1
  • (6S)-4,5,6,7-Tetrahydro-2,6-benzothiazolediamine
  • (S)-N-Despropyl PraMipexole
  • 2,6-BenzothiazolediaMine,4,5,6,7-tetrahydro-,(6S)-
  • Pramipexole Related Compound A (15 mg) ((S)-4,5,6,7-Tetrahydrobenzothiazole-2,6-diamine)
  • PraMipexole EP IMpurity A (USP RC A)
  • PraMipexole IMpurity A
  • PraMipexole IMpurity C
  • (s)-4,5,6,7-tetrahydrobenzothiazole-2,6-diaMino
  • (-)-2,6-diaMino-4,5,6,7-tetrahydroben thiazo...
  • Pramipexole impurity I
  • Pramipexole Dihydrochloride Monohydrate EP Impurity A
  • PraMipexole Related CoMpound A
  • (s)-(-) 4,5,6,7-Tetrahydrobenzothiazole-2,6-diamine 95%
  • Pramipexole-1
  • (S)-(-)-2,6-Diamino-4,5,6,7-tetrahydrobenzothiazole&gt
  • Pramipexole Impurity A1
  • (S)-2,6-Diamino-4,5,6,7-tetrahydrobenzothiazoL
  • Paramipexole Impurity-A
  • pramipexole impurities1162
  • Pramipexole EP Impurity AQ: What is Pramipexole EP Impurity A Q: What is the CAS Number of Pramipexole EP Impurity A Q: What is the storage condition of Pramipexole EP Impurity A Q: What are the applications of Pramipexole EP Impurity A
  • Pramipexole Related Compound A ((S)-4,5,6,7-Tetrahydrobenzothiazole-2,6-diamine) (1553768)
  • Pramipexole USP Related Compound A
  • (6S)-4,5,6,7-Tetrahydro-2,6-benzodthiazolediamine
  • Pramipexole Dihydrochloride Monohydrate Impurity A
  • (<i>S</i>)-(?)-2,6-Diamino-4,5,6,7-tetrahydrobenzothiazole
  • (?)-(6S)-2,6-Diamino-4,5,6,7-tetrahydrobenzothiazole
  • (S)-4,5,6,7-Tetrahydro-benzo[d]thiazol-2,6-diamine
  • 106092-09-5
  • 06092-09-5
  • API
  • (intermediate of pramipexole)
  • intermidiate of Pramipexole
  • All Inhibitors
  • Inhibitors
  • Intermediates
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Pramipexole Dihydrochloride Monohydrate