D-PYR-D-PHE-D-TRP-SER-TYR-D-TRP-LEU-ARG-PRO-GLY-NH2
- Product Name
- D-PYR-D-PHE-D-TRP-SER-TYR-D-TRP-LEU-ARG-PRO-GLY-NH2
- CAS No.
- 68059-94-9
- Chemical Name
- D-PYR-D-PHE-D-TRP-SER-TYR-D-TRP-LEU-ARG-PRO-GLY-NH2
- Synonyms
- (D-Pyr1,D-Phe2,D-Trp3;[DGLP1,DPHE2,DTRP3,6]-LH-RH;pglu(1)-phe(2)-trp(3,6)-lhr;(D-PYR1,D-PHE2,D-TRP3,6)-LHRH;LHRH, pGlu(1)-Phe(2)-Trp(3,6)-;[D-PGLU1, D-PHE2, D-TRP3,6]-LH-RH;[D-PYROGLU1,D-PHE2,D-TRP3,6]-LH-RH;[D-PYR1, D-PHE2, D-TRP3,6]-LH-RH (HUMAN);DGLP-DPHE-DTRP-SER-TYR-DTRP-LEU-ARG-PRO-GLY-NH2;D-pglu1,D-phe2,D-trp3,6-luteinizing*hormone relea
- CBNumber
- CB0278904
- Molecular Formula
- C67H84N16O13
- Formula Weight
- 1321.48
- MOL File
- 68059-94-9.mol
D-PYR-D-PHE-D-TRP-SER-TYR-D-TRP-LEU-ARG-PRO-GLY-NH2 Property
- storage temp.
- −20°C
Safety
- Hazard Codes
- T
- Risk Statements
- 60
- Safety Statements
- 53-22-36/37/39-45
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- AAA0000195
- Product name
- D-PYR-D-PHE-D-TRP-SER-TYR-D-TRP-LEU-ARG-PRO-GLY-NH2
- Purity
- 95.00%
- Packaging
- 1MG
- Price
- $730.68
- Updated
- 2021/12/16
D-PYR-D-PHE-D-TRP-SER-TYR-D-TRP-LEU-ARG-PRO-GLY-NH2 Chemical Properties,Usage,Production
Uses
[D-Glp1,D-Phe2,D-Trp3,6]-LH-RH is a Luteinizing-hormone-releasing hormone (LHRH) analogue. [D-Glp1,D-Phe2,D-Trp3,6]-LH-RH acts as a GnRH receptor antagonist[1].
in vivo
[D-Glp1,D-Phe2,D-Trp3,6]-LH-RH (1.25 and 2.5 mg, subcutaneous injection, b.i.d, for 7 days) prolongs pregnancy in rats[1].
[D-Glp1,D-Phe2,D-Trp3,6]-LH-RH (250 μg) inhibits ovulation by 100% in rats[2].
References
[1] Rivier C, et al. Effect of the LRF-antagonist [D-pGlu1, D-Phe2, D-Trp3,6]-LRF on pregnancy in the rat. Contraception. 1979 Feb;19(2):185-90. DOI:10.1016/s0010-7824(79)80030-x
[2] Rivier JE, et al. A potent luteinizing hormone releasing factor antagonist in vitro and inhibitor of ovulation in the rat. Life Sci. 1978 Aug 28;23(8):869-76. DOI:10.1016/0024-3205(78)90522-2
[3] Hsueh AJ, et al. Effect on an antagonistic analog of gonadotropin releasing hormone upon ovarian granulosa cell function. Life Sci. 1979 Oct 1;25(14):1223-9. DOI:10.1016/0024-3205(79)90464-8
D-PYR-D-PHE-D-TRP-SER-TYR-D-TRP-LEU-ARG-PRO-GLY-NH2 Preparation Products And Raw materials
Raw materials
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