1,1'-Thiocarbonyldiimidazole

Product Name: 1,1'-Thiocarbonyldiimidazole
CAS No.: 6160-65-2
Chemical Name: 1,1'-Thiocarbonyldiimidazole
Synonyms: TCDI;Di(1H-imidazol-1-yl)methanethione;1,1-THIOCARBONYLDIIMIDAZOLE;Thiocarbonyl diimidazole;bis(1H-imidazol-2-yl)methanethione;DiiMidaz;diimidazoL;1,1'-THIOCARBONYL;1,1'-Thiocarbonyldii;Thiocarbonylbisimidazole
CBNumber: CB0280138
Molecular Formula: C7H6N4S
Formula Weight: 178.21
MOL File: 6160-65-2.mol

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1,1'-Thiocarbonyldiimidazole Property

Melting point:: 98-102 °C(lit.)
Boiling point:: 342°C (rough estimate)
Density: 1.3046 (rough estimate)
refractive index: 1.5500 (estimate)
storage temp.: 2-8°C
solubility: Soluble in terahydrofuran, toluene and dichloromethane.
pka: 1.96±0.10(Predicted)
form: Powder
color: Bright yellow
Water Solubility: decomposes
Sensitive: Moisture Sensitive
BRN: 609349
Stability:: Stable, but air and moisture sensitive. Incompatible with strong oxidizing agents, strong acids.
InChIKey: RAFNCPHFRHZCPS-UHFFFAOYSA-N
CAS DataBase Reference: 6160-65-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 22-34
Safety Statements: 22-24/25-45-36/37/39-26
WGK Germany: 3
F: 9-21
Hazard Note: Irritant/Keep Cold/Moisture Sensitive
HS Code: 29332900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 156051
Product name: 1,1′-Thiocarbonyldiimidazole
Purity: technical grade, 90%
Packaging: 5g
Price: $58.3
Updated: 2024/03/01

Sigma-Aldrich

Product number: 156051
Product name: 1,1′-Thiocarbonyldiimidazole
Purity: technical grade, 90%
Packaging: 10g
Price: $110
Updated: 2024/03/01

TCI Chemical

Product number: C1376
Product name: 1,1'-Thiocarbonyldiimidazole
Purity: >95.0%(GC)(T)
Packaging: 5g
Price: $146
Updated: 2024/03/01

TCI Chemical

Product number: C1376
Product name: 1,1'-Thiocarbonyldiimidazole
Purity: >95.0%(GC)(T)
Packaging: 25g
Price: $508
Updated: 2024/03/01

Alfa Aesar

Product number: B22008
Product name: 1,1'-Thiocarbonyldiimidazole, tech 90%
Packaging: 10g
Price: $105
Updated: 2024/03/01

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1,1'-Thiocarbonyldiimidazole Chemical Properties,Usage,Production

Chemical Properties

yellow powder

Uses

1,1'-Thiocarbonyldiimidazole is used as a reagent for the deoxygenation of alcohols with tributyltin hydride and diols with lithium aluminum hydride. It is also used to deoxygenate carboxylic monosaccharide analogues. Further, it is a useful reagent involved in biochemical synthesis. In addition to this, it is used to prepare 1-[bis-(4-methoxy-phenyl)-methyl]-1H-imidazole by reacting with 4,4'-dimethoxy-benzhydrol.

Application

1,1′-Thiocarbonyldiimidazole (TCDI) is generally used as a reagent to carry out the deoxygenation of vicinal diols by forming cyclic thionocarbonate in Corey-Winter alkene synthesis.
It is used as a reagent in the enantioselective total synthesis of (+)-hapalindole Q, 12-epi-fischerindole U and welwitindolinone A.
It is also used in the preparation of trithiocarbonates, xanthates, and dithiocarbamates as chain transfer agents for the reversible addition fragmentation chain transfer and macromolecular design (RAFT/ MADIX) polymerization.

Uses

1,1’Thiocarbonyldiimidazole can be used to deoxygenate carboxylic monosaccharide analogues.

Synthesis Reference(s)

The Journal of Organic Chemistry, 43, p. 337, 1978 DOI: 10.1021/jo00396a035

Purification Methods

It forms yellow crystals on recrystallisation from tetrahydrofuran or by sublimation at 10-3torr (bath temperature 70-80o). It is hydrolysed by H2O and should be stored dry. [Staab & Walther Justus Liebigs Ann Chem 657 98 1962; Pullukat et al. Tetrahedron Lett 1953 1967, Hanessian et al. Can J Chem 65 1859 1987, Rajanbabu et al. J Am Chem Soc 111 1759 1989.] Thiochrome {2,7-dimethyl-5H -thiachromine-8-ethanol; 3,8-dimethyl-2-hydroxyethyl-5H -

1,1'-Thiocarbonyldiimidazole Preparation Products And Raw materials

Raw materials

Preparation Products

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1,1'-Thiocarbonyldiimidazole Suppliers

Americas 1 Belgium 2 Canada 4 China 358 China Hong Kong 1 Europe 4 Germany 6 India 25 Japan 7 Poland 1 Slovakia 1 South Korea 2 Switzerland 2 Ukraine 2 United Kingdom 19 United States 39 Global 474

Nanjing Gold Pharmaceutical Technology Co. Ltd.

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Shanghai Witofly Chemical Co. ,Ltd.

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Anhui Shuoyuan Pharmaceutical Technology R&D Co.,Ltd

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Shanghai NAIFU Biotechnology Co., Ltd

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J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

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View Lastest Price from 1,1'-Thiocarbonyldiimidazole manufacturers

Hebei Duling International Trade Co. LTD

Product: 1,1'-Thiocarbonyldiimidazole 6160-65-2
Price: US $1.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000 Ton
Release date: 2022-10-10

Shaanxi Dideu Medichem Co. Ltd

Product: 1,1'-Thiocarbonyldiimidazole 6160-65-2
Price: US $0.00-0.00/KG
Min. Order: 5mg
Purity: 99%HPLC
Supply Ability: 2000tons
Release date: 2020-01-06

Hebei Guanlang Biotechnology Co., Ltd.

Product: 1,1'-Thiocarbonyldiimidazole 6160-65-2
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2023-03-15

6160-65-2, 1,1'-ThiocarbonyldiimidazoleRelated Search:

1,1'-Carbonyldiimidazole Imidazole Fenbendazole Albendazole N,O-Bis(trimethylsilyl)acetamide N,N'-Dibenzyl ethylenediamine diacetate N,N'-Diisopropylcarbodiimide N,N-Dimethyl-p-toluidine N,N'-Disuccinimidyl carbonate 1,1,2-TRICHLORO-2,3,3-TRIFLUOROCYCLOBUTANE Nickel carbonyl powder Sodium thiosulfate pentahydrate Adapalene Methimazole 1-Methylimidazole 1,1'-Thiocarbonyldiimidazole

N,N'-THIOCARBONYLDIIMIDAZOLE

TCDI

1,1'-thiocarbonylbis(imidazole)

1,1'-THIOCARBONYLDIIMIDAZOLE

1-(1H-IMidazol-1-ylcarbothioyl)-1H-iMidazole

DiiMidaz

1,1'-CARBONOTHIOYLBIS-1H-IMIDAZOLE

N, N - sulfur carbonyl iMidazole

1,1'-Thiocarbonyldiimidazole >=95.0% (S)

1,1'-Thiocarbonyldiimidazole technical grade, 90%

1,1'-Thiocarbonyldiimidazole, technical, 90%

1,1'-THIOCARBONYL

1,1-THIOCARBONYLDIIMIDAZOLE

Thiocarbonyl diimidazole

1,1'-THIOCARBONYLDIIMIDAZOLE, TECH., 90%

N,N'-THIOCARBONYLDIIMIDAZOLE(TCDI)

1,1,-ThiocarbonyldiimidazoleTech90%

1,1'-Thiocarbonyldiimidazole,95%

1H-Imidazole, 1,1-carbonothioylbis-

N,N’-Thiocarboryldiimidazole

1,1''-THIOCARBONYLDIIMIDAZOLE (TCDI)

Bis(1H-imidazole-1-yl) thioketone

Bis(1-imidazolyl) thioketone

Di(imidazol-1-yl)methanethione

Thiocarbonylbisimidazole

1,1'-Thiocarbonyldiimidazole,90%,tech.

1.1'-Thiocarbonyldiimidazole 100mg [6160-65-2]

1,1'-Thiocarbonyldiimidazole, tech 90%

1,1'-Thiocarbonyldii

N'-ThiocarbonyldiiMidazole(TCDI)

1,1'-Thiocarbonyldi(1H-imidazole) 90%

Di(1H-imidazol-1-yl)methanethione

bis(1H-imidazol-2-yl)methanethione

diimidazoL

1,1'-Thiocarbonyldiimidazole &gt

Methanethione, di-1H-imidazol-1-yl-

1,1'-Thicarbonyldiimidazole

TIANFU-CHEM 6160-65-2 1,1'-Thiocarbonyldiimidazole

THEOCARBONYL DIIMIDAZOLE

1,1'-Thiocarbonyldiimidazole

6160-65-2

228-183-4

Building Blocks

Carbonyldiimidazole Derivatives

Synthetic Reagents

Imidazoles

Coupling

Heterocyclic Building Blocks

Carbonyldiimidazole Derivatives

Coupling

Synthetic Reagents

Carbonyldiimidazole DerivativesBuilding Blocks

Heterocyclic Building Blocks

Imidazoles