HNE

Product Name: HNE
CAS No.: 75899-68-2
Chemical Name: HNE
Synonyms: 4-HNE;4-HYDROXYNONENAL;4-HYDROXY-2-NONENAL;(E)-4-hydroxynon-2-enal;HNE;Ccris 1781;4-hydroxy-2-nonena;(E)-4-HYDROXYNONENAL;(±)4-Hydroxynon-2-enal;4-HNE/4-Hydroxynonenal
CBNumber: CB0281140
Molecular Formula: C9H16O2
Formula Weight: 156.22
MOL File: 75899-68-2.mol

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HNE Property

Boiling point:: 125-127 °C(Press: 2 Torr)
Density: 0.941±0.06 g/cm3(Predicted)
storage temp.: -70°C
solubility: DMF: >50 mg/ml; DMSO: >50 mg/ml; Ethanol: >50 mg/ml; PBS pH 7.2: >1 mg/ml
pka: 13.31±0.20(Predicted)
form: Colorless oil.
color: Colorless to light yellow
InChI: InChI=1S/C9H16O2/c1-2-3-4-6-9(11)7-5-8-10/h5,7-9,11H,2-4,6H2,1H3/b7-5+
InChIKey: JVJFIQYAHPMBBX-FNORWQNLSA-N
SMILES: C(=O)/C=C/C(O)CCCCC
CAS DataBase Reference: 75899-68-2(CAS DataBase Reference)

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Safety

WGK Germany: WGK 3
Storage Class: 3 - Flammable liquids
Hazard Classifications: Eye Irrit. 2
Flam. Liq. 2

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 393204
Product name: 4-Hydroxynonenal-CAS75899-68-2-Calbiochem
Purity: 4-Hydroxynonenal,CAS75899-68-2,isamajoraldehydeproductformedbyperoxida
Packaging: 1mg
Price: $148
Updated: 2025/07/31

Cayman Chemical

Product number: 32100
Product name: 4-hydroxy Nonenal
Purity: ≥98%
Packaging: 1mg
Price: $78
Updated: 2024/03/01

Cayman Chemical

Product number: 32100
Product name: 4-hydroxy Nonenal
Purity: ≥98%
Packaging: 5mg
Price: $311
Updated: 2024/03/01

Cayman Chemical

Product number: 32100
Product name: 4-hydroxy Nonenal
Purity: ≥98%
Packaging: 10mg
Price: $543
Updated: 2024/03/01

Cayman Chemical

Product number: 32100
Product name: 4-hydroxy Nonenal
Purity: ≥98%
Packaging: 50mg
Price: $1912
Updated: 2022/04/27

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HNE Chemical Properties,Usage,Production

Uses

4-Hydroxynonenal is an irreversible inhibitor of Na+/K+-ATPase activity.

Uses

HNE is a lipid peroxidation product derived from oxidized ω-6 polyunsaturated fatty acids such as arachidonic acid. 4-hydroxy Nonenal is widely used as a marker of lipid peroxidation. It exhibits various biological activities such as cytotoxicity, growth inhibiting activity, genotoxicity, and chemotactic activity. HNE inhibits pro-oxidant-induced Ca²⁺release from mitochondria at 10-50 μM.[Cayman Chemical]

Definition

ChEBI: 4-hydroxynon-2-enal is an enal consisting of non-2-ene having an oxo group at the 1-position and a hydroxy group at the 4-position. It has a role as a human metabolite. It is a hydroxyaldehyde, an enal and a 4-hydroxynonenal.

Biological Activity

Primary Target
Na+, K+-ATPase activity', 'Product does not compete with ATP.', 'Target IC50: 120 μM against Na+, K+-ATPase activity

in vivo

Following 24 h after fluid percussion injury (FPI), the mouse brain tissue is analyzed for the expression level of NADPH oxidase 1 (NOX1), inducible nitric oxide synthase (iNOS), 4-Hydroxynonenal (4-HNE. Both wild-type (Nrf2^+/+) and Nrf2-deficient mice (Nrf2^-/-) results in increased expression of 4-Hydroxynonenal following 15 psi injury (moderate injury) when compared to uninjured Nrf2^+/+ and Nrf2^-/- mice. Similar to iNOS result, in Nrf2^-/- KO mice, the expression level of 4-Hydroxynonenal is significantly high when compared to corresponding injured and uninjured Nrf2^+/+ WT animals^[2].

IC 50

ALDH2; Human Endogenous Metabolite

HNE Preparation Products And Raw materials

Raw materials

Preparation Products

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HNE Suppliers

China 118 France 1 Germany 2 India 1 Japan 1 Switzerland 1 Ukraine 1 United Kingdom 2 United States 21 Global 148

Nantong Hi-Future Biotechnology Co., Ltd

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MedBioPharmaceutical Technology Inc

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Zhenjiang D&A Biological Technology Co., Ltd.

Tel: 18912101619
Email: wxf2005a@126.com
Country: China
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Shanghai Kaisen Biotechnology Co., Ltd

Tel: 17558870519
Email: sales02@chemsoon.com
Country: China
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3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
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Wuhan TCASChem Technology Co., Ltd.

Tel: 027-86697669 13986148687
Fax: 86-027-86697669
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Country: China
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SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD

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Country: China
ProdList: 984
Advantage: 58

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185 18149758185;
Email: sales-cpd@caerulumpharma.com
Country: China
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Shanghai Meishui Chemical Technology Co., Ltd

Tel: 021-60549325 18616193163
Fax: 021-33250306
Country: China
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Yichang Zhongyitai Trading Co., Ltd.

Tel: 0717-6449896 13886658719
Fax: 0717-6558598
Email: root@zhongyitai.com
Country: China
ProdList: 1978
Advantage: 58

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View Lastest Price from HNE manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: HNE 75899-68-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

75899-68-2, HNERelated Search:

Titanium tetrachloride Glutathione 4-hydroxy Nonenal-d3 (E)-4-HYDROXY-2-NONENAL,TRANS-4-HYDROXY-2-NONENAL TRANS-4-HYDROXY-2-NONENAL-5,5,6,6,7,7,8,8,9,9,9-D11 DIMETHYL ACETAL (E)-4-HYDROXYNONENAL-DIMETHYLACETAL,(E)-4-Hydroxynonenal-dimethylacetal, 4-HNE-DMA,(E)-4-Hydroxynonenal-dimethylacetal, 4-HNE-DMA,HNE-DA,HNE-DMA (E)-4-HYDROXYNONENAL, >85% HNE INHIBITOR ANTI-HNE FLUOROPHORE TAC, CD70, CD27 Ligand, Clone: HNE.51, Mab anti-Human, FITC ANTI-HNE PAB,ANTISERUM TO (E)-4-HYDROXYNONENAL 4-Hydroxynonenal conj. BSA Purified ANTI-(E)-4-HYDROXYNONENAL,ANTI-HNE,ANTI-4-HYDROXY-2-NONENAL 4R-HYDROXY-2-NONENAL ANTI-HNE-MICHAEL ADDUCTS, REDUCED,ANTI-HNE-MICHAEL ADDUCTS, REDUCED (RABBIT),ANTI-HNE-MICHAEL ADDUCTS, REDUCED RABBIT PAB 4S-HYDROXY-2-NONENAL TAC, CD70, CD27 Ligand, Clone: HNE.51, Mab anti-Human HNE (4-Hydroxy-2-nonenal),HNE (4-Hydroxy-2-nonenal)

Ccris 1781

(E)-4-HYDROXYNONENAL

HNE

4-HYDROXY-2-NONENAL

4-HNE

(+/-)-4-HYDROXY-2E-NONENAL

(+/-)-4-HYDROXYNON-2-ENAL

4-HYDROXYNONENAL

4-hydroxy-2-nonena

(E)-4-hydroxynon-2-enal

2-Nonenal, 4-hydroxy-, (2E)-

HNE ISO 9001：2015 REACH

biomarker,genotoxic,oxidative,Inhibitor,stress,Cancer,Aldehyde Dehydrogenase (ALDH),4-Hydroxynonenal,Endogenous Metabolite,4Hydroxynonenal,nitrosative,mitochondria,4 Hydroxynonenal,inhibit

Rabbit Anti-4 Hydroxynonenal antibody

Rabbit Anti-4 Hydroxynonenal/PE Conjugated antibody

Rabbit Anti-4 Hydroxynonenal/AF647 Conjugated antibody

4-Hydroxynonenal, Lipid peroxidation marker

4-Hydroxynonenal, 10 mM in DMSO

(±)4-Hydroxynon-2-enal

Mouse 4-Hydroxy-2-nonenal elisa kit

4-HNE/4-Hydroxynonenal

75899-68-2

9001-90-6