ChemicalBook > CAS DataBase List > 3-(3,4,5-TRIMETHOXYPHENYL)PROPIONIC ACID

3-(3,4,5-TRIMETHOXYPHENYL)PROPIONIC ACID

Product Name: 3-(3,4,5-TRIMETHOXYPHENYL)PROPIONIC ACID
CAS No.: 25173-72-2
Chemical Name: 3-(3,4,5-TRIMETHOXYPHENYL)PROPIONIC ACID
Synonyms: AKOS BBS-00006959;TIMTEC-BB SBB000794;LABOTEST-BB LT00233171;5-Trimethoxyphenyl)propanoic acid;3,4,5-TRIMETHOXYHYDROCINNAMIC ACID;3,4,5-Trimethoxyphenylpropionic acid;3,4,5-trimethoxydihydrocinnamic acid;3-(3,4,5-trimethoxyphenyl)propanoate;3,4,5-Trimethoxybenzenepropanoic acid;3,4,5-Trimethoxybenzenepropionic acid
CBNumber: CB0283225
Molecular Formula: C12H16O5
Formula Weight: 240.25
MOL File: 25173-72-2.mol

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3-(3,4,5-TRIMETHOXYPHENYL)PROPIONIC ACID Property

Melting point:: 100-104 °C (lit.)
Boiling point:: 373℃
Density: 1.169
refractive index: 1.5140 (estimate)
Flash point:: 140℃
storage temp.: Sealed in dry,Room Temperature
solubility: methanol: 0.1 g/mL, clear
form: Crystalline Powder
pka: 4.70±0.10(Predicted)
color: White to almost white
BRN: 1471912
InChI: InChI=1S/C12H16O5/c1-15-9-6-8(4-5-11(13)14)7-10(16-2)12(9)17-3/h6-7H,4-5H2,1-3H3,(H,13,14)
InChIKey: ZCYXGVJUZBKJAI-UHFFFAOYSA-N
SMILES: C1(CCC(O)=O)=CC(OC)=C(OC)C(OC)=C1
CAS DataBase Reference: 25173-72-2(CAS DataBase Reference)

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Safety

Risk Statements: 36/37/38
Safety Statements: 22-24/25
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 197874
Product name: 3-(3,4,5-Trimethoxyphenyl)propionic acid
Purity: ≥98%
Packaging: 25g
Price: $300
Updated: 2023/06/20

TCI Chemical

Product number: T4336
Product name: 3-(3,4,5-Trimethoxyphenyl)propanoic Acid
Purity: min. 97.0 %
Packaging: 5G
Price: $85
Updated: 2025/07/31

TCI Chemical

Product number: T4336
Product name: 3-(3,4,5-Trimethoxyphenyl)propanoic Acid
Purity: min. 97.0 %
Packaging: 25G
Price: $255
Updated: 2025/07/31

TRC

Product number: T797295
Product name: 3-(3,4,5-Trimethoxyphenyl)propanoicAcid
Packaging: 250mg
Price: $45
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2721-1-51
Product name: 3-(3,4,5-Trimethoxyphenyl)propionic acid
Packaging: 5G
Price: $65
Updated: 2021/12/16

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3-(3,4,5-TRIMETHOXYPHENYL)PROPIONIC ACID Chemical Properties,Usage,Production

Chemical Properties

WHITE TO ALMOST WHITE CRYSTALLINE POWDER

Uses

3-(3,4,5-Trimethoxyphenyl)propanoic acid is found in herbs and spices. 3-(3,4,5-Trimethoxyphenyl)propanoic acid is a constituent of Piper longum (long pepper) and Piper retrofractum (Javanese long pepper).

Definition

ChEBI: A monocarboxylic acid consisting of propionic acid having a 3,4,5-trimethoxyphenyl substituent at the 3-position.

Synthesis

20329-98-0

25173-72-2

General procedure for the synthesis of 3-(3,4,5-trimethoxyphenyl)propionic acid from (E)-3-(3,4,5-trimethoxyphenyl)propenoic acid (by microwave radiation method): in a 100 mL Erlenmeyer flask, 3,4,5-trimethoxycinnamic acid (0.72 g, 0.003 mol) and PdCl2 (55 mg, 0.31 mmol) were suspended in 10% sodium hydroxide solution (6-10 mL), followed by batchwise addition of formic acid (8-12 mL). The mixture was reacted under microwave radiation for 3-5 min until the feedstock completely disappeared. Upon completion of the reaction, the cooled mixture was poured into ice water, acidified with 5% HCl and extracted with dichloromethane (3 x 10 mL). The organic layer was washed with water and dried with anhydrous Na2SO4. The solvent was removed by evaporation and the crude product was recrystallized by a solvent mixture of ethyl acetate and hexane to give 3-(3,4,5-trimethoxyphenyl)propionic acid as a white solid in 84% yield with a melting point of 102 °C (literature value 101-102 °C).1H NMR (CDCl3) δ: 6.70 (2H, s, H-2 and H-6), 3.84 (9H, s, 3-OCH3,4- OCH3 and 5-OCH3), 2.92 (2H, t, Ar-CH2-CH2-COOH), 2.70 (2H, t, -CH2-CH2-COOH); 13C NMR δ: 178.1 (COOH), 153.1 (C-3 and C-5), 135.87 (C-4 and C-1), 105.3 (C-2 and C-6) , 60.8 (4-OCH3), 56.1 (3-OCH3 and 5-OCH3), 35.5 (Ar-CH2-), 31.0 (-CH2-COOH).

IC 50

Human Endogenous Metabolite

References

[1] Journal of Organic Chemistry, 2015, vol. 80, # 24, p. 11953 - 11962
[2] Chemistry Letters, 2003, vol. 32, # 12, p. 1186 - 1187
[3] Patent: US2004/118673, 2004, A1. Location in patent: Page 7
[4] Bioorganic Chemistry, 2018, vol. 80, p. 408 - 421
[5] Angewandte Chemie - International Edition, 2014, vol. 53, # 30, p. 7785 - 7788

3-(3,4,5-TRIMETHOXYPHENYL)PROPIONIC ACID Preparation Products And Raw materials

Raw materials

3,4,5-Trimethoxybenzaldehyde Palladium Malonic acid

Preparation Products

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3-(3,4,5-TRIMETHOXYPHENYL)PROPIONIC ACID Suppliers

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View Lastest Price from 3-(3,4,5-TRIMETHOXYPHENYL)PROPIONIC ACID manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: 3-(3,4,5-TRIMETHOXYPHENYL)PROPIONIC ACID 25173-72-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Career Henan Chemical Co

Product: me: 3-(3,4,5-TRIMETHOXYPHENYL)PROPIONIC ACID 25173-72-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95-99%
Supply Ability: 500kg/month
Release date: 2019-08-01

25173-72-2, 3-(3,4,5-TRIMETHOXYPHENYL)PROPIONIC ACIDRelated Search:

Desoxypodophyllotoxin 3-(3,4,5-TRIMETHOXYPHENYL)PROPIONIC ACID 3-OXO-3-(2,3,4-TRIMETHOXYPHENYL)PROPIONIC ACID ETHYL ESTER (-)PPP ETHYL 3-(3,4,5-TRIMETHOXYPHENYL)PROPIONATE 3-OXO-3-(2,3,4-TRIMETHOXYPHENYL)PROPIONIC ACID ETHYL ESTER Podophyllotoxin glucoside 3-AMINO-3-(3,4,5-TRIMETHOXY-PHENYL)-PROPIONIC ACID 3,5-PYRIDINEDICARBOXYLIC ACID, 1,4-DIHYDRO-2,6-DIMETHYL-4-(3,4,5-TRIMETHOXYPHENYL)-, DIETHYL ESTER 3-OXO-3-(2,3,6-TRIMETHOXYPHENYL)PROPIONIC ACID METHYL ESTER 3-(2,3,4-TRIMETHOXYPHENYL)PROPIONIC ACID 3-(2,4,6-trimethoxyphenyl)propionic acid 3-OXO-3-(3,4,5-TRIMETHOXYPHENYL)PROPIONIC ACID METHYL ESTER 2-(2,3,4-trimethoxyphenyl)propionic acid diethyl (3,4,5-trimethoxybenzoyl)malonate METHYL 3-(3,4,5-TRIMETHOXYPHENYL)PROPANOATE 2-oxo-3-(3,4,5-trimethoxyphenyl)propanoic acid RARECHEM AK HF T328

TIMTEC-BB SBB000794

3,4,5-TRIMETHOXYHYDROCINNAMIC ACID

3-(3,4,5-TRIMETHOXYPHENYL)PROPANOIC ACID

3-(3,4,5-TRIMETHOXYPHENYL)PROPIONIC ACID

AKOS BBS-00006959

LABOTEST-BB LT00233171

BETA-(3,4,5-TRIMETHOXYPHENYL)PROPIONIC ACID

B-(3,4,5-TRIMETHOXYPHENYL)PROPIONIC ACID

3,4,5-Trimethoxyphenylpropionic acid

Benzenepropanoic acid, 3,4,5-trimethoxy-

3-(3,4,5-TRIMETHOXYPHENYL)PROPIONIC ACID , 98+%

3,4,5-trimethoxydihydrocinnamic acid

3,4,5-Trimethoxybenzenepropanoic acid

3,4,5-Trimethoxybenzenepropionic acid

3-(3,4,5-Trimethoxyphenyl)propionic acid ,99%

3,4,5-Trimethoxy-beta-phenylpropionic acid

me: 3-(3,4,5-TRIMETHOXYPHENYL)PROPIONIC ACID

3-(3,4,5-trimethoxyphenyl)propanoate

5-Trimethoxyphenyl)propanoic acid

3(3,4,5Trimethoxyphenyl)propanoic acid,Endogenous Metabolite,Inhibitor,3 (3,4,5 Trimethoxyphenyl)propanoic acid,inhibit

25173-72-2

15173-72-2

CH3O3C6H2CH2CH2CO2H

CARBOXYLIC ACID

Organic Building Blocks

Building Blocks

Carbonyl Compounds

Carboxylic Acids

C11 to C12

Aromatic Propionic Acids

API intermediates