3-(3,4,5-TRIMETHOXYPHENYL)PROPIONIC ACID
- Product Name
- 3-(3,4,5-TRIMETHOXYPHENYL)PROPIONIC ACID
- CAS No.
- 25173-72-2
- Chemical Name
- 3-(3,4,5-TRIMETHOXYPHENYL)PROPIONIC ACID
- Synonyms
- AKOS BBS-00006959;TIMTEC-BB SBB000794;LABOTEST-BB LT00233171;5-Trimethoxyphenyl)propanoic acid;3,4,5-TRIMETHOXYHYDROCINNAMIC ACID;3,4,5-Trimethoxyphenylpropionic acid;3,4,5-trimethoxydihydrocinnamic acid;3-(3,4,5-trimethoxyphenyl)propanoate;3,4,5-Trimethoxybenzenepropanoic acid;3,4,5-Trimethoxybenzenepropionic acid
- CBNumber
- CB0283225
- Molecular Formula
- C12H16O5
- Formula Weight
- 240.25
- MOL File
- 25173-72-2.mol
3-(3,4,5-TRIMETHOXYPHENYL)PROPIONIC ACID Property
- Melting point:
- 100-104 °C (lit.)
- Boiling point:
- 373℃
- Density
- 1.169
- refractive index
- 1.5140 (estimate)
- Flash point:
- 140℃
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- methanol: 0.1 g/mL, clear
- form
- Crystalline Powder
- pka
- 4.70±0.10(Predicted)
- color
- White to almost white
- BRN
- 1471912
- InChI
- InChI=1S/C12H16O5/c1-15-9-6-8(4-5-11(13)14)7-10(16-2)12(9)17-3/h6-7H,4-5H2,1-3H3,(H,13,14)
- InChIKey
- ZCYXGVJUZBKJAI-UHFFFAOYSA-N
- SMILES
- C1(CCC(O)=O)=CC(OC)=C(OC)C(OC)=C1
- CAS DataBase Reference
- 25173-72-2(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 197874
- Product name
- 3-(3,4,5-Trimethoxyphenyl)propionic acid
- Purity
- ≥98%
- Packaging
- 25g
- Price
- $300
- Updated
- 2023/06/20
- Product number
- T4336
- Product name
- 3-(3,4,5-Trimethoxyphenyl)propanoic Acid
- Purity
- min. 97.0 %
- Packaging
- 5G
- Price
- $85
- Updated
- 2025/07/31
- Product number
- T4336
- Product name
- 3-(3,4,5-Trimethoxyphenyl)propanoic Acid
- Purity
- min. 97.0 %
- Packaging
- 25G
- Price
- $255
- Updated
- 2025/07/31
- Product number
- T797295
- Product name
- 3-(3,4,5-Trimethoxyphenyl)propanoicAcid
- Packaging
- 250mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 2721-1-51
- Product name
- 3-(3,4,5-Trimethoxyphenyl)propionic acid
- Packaging
- 5G
- Price
- $65
- Updated
- 2021/12/16
3-(3,4,5-TRIMETHOXYPHENYL)PROPIONIC ACID Chemical Properties,Usage,Production
Chemical Properties
WHITE TO ALMOST WHITE CRYSTALLINE POWDER
Uses
3-(3,4,5-Trimethoxyphenyl)propanoic acid is found in herbs and spices. 3-(3,4,5-Trimethoxyphenyl)propanoic acid is a constituent of Piper longum (long pepper) and Piper retrofractum (Javanese long pepper).
Definition
ChEBI: A monocarboxylic acid consisting of propionic acid having a 3,4,5-trimethoxyphenyl substituent at the 3-position.
Synthesis
20329-98-0
25173-72-2
General procedure for the synthesis of 3-(3,4,5-trimethoxyphenyl)propionic acid from (E)-3-(3,4,5-trimethoxyphenyl)propenoic acid (by microwave radiation method): in a 100 mL Erlenmeyer flask, 3,4,5-trimethoxycinnamic acid (0.72 g, 0.003 mol) and PdCl2 (55 mg, 0.31 mmol) were suspended in 10% sodium hydroxide solution (6-10 mL), followed by batchwise addition of formic acid (8-12 mL). The mixture was reacted under microwave radiation for 3-5 min until the feedstock completely disappeared. Upon completion of the reaction, the cooled mixture was poured into ice water, acidified with 5% HCl and extracted with dichloromethane (3 x 10 mL). The organic layer was washed with water and dried with anhydrous Na2SO4. The solvent was removed by evaporation and the crude product was recrystallized by a solvent mixture of ethyl acetate and hexane to give 3-(3,4,5-trimethoxyphenyl)propionic acid as a white solid in 84% yield with a melting point of 102 °C (literature value 101-102 °C).1H NMR (CDCl3) δ: 6.70 (2H, s, H-2 and H-6), 3.84 (9H, s, 3-OCH3,4- OCH3 and 5-OCH3), 2.92 (2H, t, Ar-CH2-CH2-COOH), 2.70 (2H, t, -CH2-CH2-COOH); 13C NMR δ: 178.1 (COOH), 153.1 (C-3 and C-5), 135.87 (C-4 and C-1), 105.3 (C-2 and C-6) , 60.8 (4-OCH3), 56.1 (3-OCH3 and 5-OCH3), 35.5 (Ar-CH2-), 31.0 (-CH2-COOH).
IC 50
Human Endogenous Metabolite
References
[1] Journal of Organic Chemistry, 2015, vol. 80, # 24, p. 11953 - 11962
[2] Chemistry Letters, 2003, vol. 32, # 12, p. 1186 - 1187
[3] Patent: US2004/118673, 2004, A1. Location in patent: Page 7
[4] Bioorganic Chemistry, 2018, vol. 80, p. 408 - 421
[5] Angewandte Chemie - International Edition, 2014, vol. 53, # 30, p. 7785 - 7788
3-(3,4,5-TRIMETHOXYPHENYL)PROPIONIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
3-(3,4,5-TRIMETHOXYPHENYL)PROPIONIC ACID Suppliers
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View Lastest Price from 3-(3,4,5-TRIMETHOXYPHENYL)PROPIONIC ACID manufacturers
- Product
- 3-(3,4,5-TRIMETHOXYPHENYL)PROPIONIC ACID 25173-72-2
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
- Product
- me: 3-(3,4,5-TRIMETHOXYPHENYL)PROPIONIC ACID 25173-72-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95-99%
- Supply Ability
- 500kg/month
- Release date
- 2019-08-01