ChemicalBook > CAS DataBase List > BOC-D-4,4'-BIPHENYLALANINE

BOC-D-4,4'-BIPHENYLALANINE

Product Name
BOC-D-4,4'-BIPHENYLALANINE
CAS No.
128779-47-5
Chemical Name
BOC-D-4,4'-BIPHENYLALANINE
Synonyms
BOC-D-4;impurity 43;BOC-D-BPH-OH;BOC-D-BIP-OH;-BIPHENYLALANINE;BOC-D-BIP(4,4')-OH;SACUBITRIL(LCZ696);BOC-D-4,4'-BIPHE-OH;LCZ-696 Impurity 80;BOC-4-BIPHENYL-D-ALA
CBNumber
CB0285209
Molecular Formula
C20H23NO4
Formula Weight
341.4
MOL File
128779-47-5.mol
More
Less

BOC-D-4,4'-BIPHENYLALANINE Property

Boiling point:
528.2±50.0 °C(Predicted)
Density 
1.161±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
3.88±0.10(Predicted)
Appearance
White to off-white Solid
CAS DataBase Reference
128779-47-5(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xi
HS Code 
2922498590
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

More
Less

N-Bromosuccinimide Price

TRC
Product number
B642900
Product name
Boc-D-4,4''-biphenylalanine
Packaging
1g
Price
$95
Updated
2021/12/16
ChemScene
Product number
CS-W023100
Product name
[1,1'-Biphenyl]-4-propanoicacid,α-[[(1,1-dimethylethoxy)carbonyl]amino]-,(αR)-
Purity
99.43%
Packaging
10g
Price
$113
Updated
2021/12/16
AK Scientific
Product number
V1221
Product name
Boc-D-4,4'-Biphenylalanine
Packaging
1g
Price
$77
Updated
2021/12/16
Matrix Scientific
Product number
074852
Product name
Boc-D-4,4-Biphenylalanine
Purity
95+%
Packaging
5g
Price
$125
Updated
2021/12/16
Activate Scientific
Product number
AS32716
Product name
Boc-D-4,4-Biphenylalanine
Purity
95+% ee
Packaging
5G
Price
$131
Updated
2021/12/16
More
Less

BOC-D-4,4'-BIPHENYLALANINE Chemical Properties,Usage,Production

Uses

Boc-D-4,4'-biphenylalanine is used as a reagent in the synthesis of pyrrolopyrimidine inhibitors of Akt as antitumor agents. Boc-D-4,4'-biphenylalanine is also used in the preparation of (-)-Bestatin-based inhibitors.

Synthesis

24424-99-5

155760-02-4

119273-61-9

To a mixed solution of tetrahydrofuran (THF) (80 mL) and water (80 mL) of (S)-3-([1,1'-biphenyl]-4-yl)-2-aminopropanoic acid (25) (5 g, 20.72 mmol) was added di-tert-butyl dicarbonate (BOC2O) (5.77 mL, 24.87 mmol) and sodium hydroxide (NaOH) (1.077 g. 26.9 mmol). The reaction mixture was stirred at room temperature for 6 hours before being cooled to 0 °C and the pH was adjusted to about 6-7 by slowly adding 1.5 N aqueous hydrochloric acid (HCl) to quench the reaction. Subsequently, the reaction mixture was extracted with ethyl acetate (EtOAc) (3 x 50 mL). The combined organic layers were washed sequentially with brine (50 mL) and water (50 mL), dried over anhydrous sodium sulfate and concentrated to give the crude product as a colloidal off-white solid. The crude product was purified by washing with petroleum ether (PE) with 10% ethyl acetate (4 x 20 mL). The resulting white solid was filtered and dried under vacuum to afford (S)-3-([1,1'-biphenyl]-4-yl)-2-((tert-butoxycarbonyl)amino)propionic acid (26) (6.5 g, 19.04 mmol, 92% yield). The product was analyzed by 1H NMR (400 MHz, DMSO-d6) and mass spectrometry (ESI) to confirm the structure.1H NMR data: δ 7.67-7.62 (m, 2H), 7.58 (d, J=8.5 Hz, 2H), 7.50-7.43 (m, 2H), 7.39-7.31 (m, 3H), 7.10 (d, J=8.0 Hz. 1H), 4.17-4.07 (m, 1H), 3.07 (dd, J=13.6,4.5Hz, 1H), 2.88 (dd, J=13.6,10.0Hz, 1H), 1.37-1.23 (m, 9H). Mass spectral data: 340.2 ([M-1]-).

References

[1] Tetrahedron Letters, 2018, p. 4267 - 4271

BOC-D-4,4'-BIPHENYLALANINE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

BOC-D-4,4'-BIPHENYLALANINE Suppliers

China 121 France 1 Germany 3 India 2 Japan 2 South Korea 1 United Kingdom 5 United States 23 Global 158
Interchim S.A.
Tel
--
Fax
--
Email
interchim@interchim.com
Country
France
ProdList
6302
Advantage
76
More
Less

View Lastest Price from BOC-D-4,4'-BIPHENYLALANINE manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
BOC-D-4,4"-BIPHENYLALANINE 128779-47-5
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Career Henan Chemical Co
Product
BOC-D-4,4'-BIPHENYLALANINE 128779-47-5
Price
US $7.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2018-12-24
Career Henan Chemical Co
Product
BOC-D-4,4'-BIPHENYLALANINE 128779-47-5
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2018-12-24

128779-47-5, BOC-D-4,4'-BIPHENYLALANINERelated Search:

Telmisartan Impurity 10 1426129-50-1 enantioMer (R,E)-ethyl 5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoate N-[2’-(1H-tetrazol-5-yl)biphenyl-4-yl methyl]-N-Valeryl-(L)-Valine benzyl ester N-NITROSO-DI-ISO-PROPYLAMINE LCZ-696 Impurity 60 Valsartan Impurity 32 (2R,4S)-ethyl 5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoate Valsartan Impurity 1 [1,1'-Biphenyl]-4-pentanoic acid, γ-amino-α-methyl-, ethyl ester, (Hydrochloride)(1:1), (αS,γS)- 4-(2-Cyanophenyl)benzyl alcohol Valsartan n-Propyl Valsartan Desvaleryl Impurity Isoleucine Valsartan USAWIVMZUYOXCF-UHFFFAOYSA-N Valsartan Ethyl Ester Valsartan Impurity 3 Valsartan Impurity 61

  • BOC-D-PHE(4-PHENYL)-OH
  • BOC-D-BPH-OH
  • BOC-D-BIP(4,4')-OH
  • BOC-D-BIP-OH
  • BOC-D-ALA(4,4'-BIPHENYL)-OH
  • BOC-3-(4-BIPHENYLYL)-D-ALANINE
  • BOC-4-PHENYL-D-PHENYLALANINE
  • BOC-4-PHENYL-D-PHE-OH
  • BOC-4-BIPHENYL-D-ALA
  • BOC-BETA-(4-BIPHENYLYL)-D-ALA-OH
  • BOC-P-PHENYL-D-PHE-OH
  • BOC-(R)-2-AMINO-3-(1,1'-BIPHENY-4-YL)PROPANOIC ACID
  • D-TBOC-P-BIPHENYLALANINE
  • (R)-3-BIPHENYL-4-YL-2-TERT-BUTOXYCARBONYLAMINO-PROPIONIC ACID
  • Boc-D-4-Phenylphenylalanine
  • N-ALPHA-T-BUTOXYCARBONYL-D-4,4'-BIPHENYLALANINE
  • N-ALPHA-T-BUTOXYCARBONYL-D-(4-PHENYL)PHENYLALANINE
  • (R)-N-ALPHA-TERT-BUTYLOXYCARBONYL-BIPHENYLALANINE
  • N-Boc-3-(4-biphenylyl)-D-alanine, 95%
  • (2R)-3-(Biphenyl-4-yl)-2-[(tert-butoxycarbonyl)amino]propanoic acid
  • (2R)-3-(Biphenyl-4-yl)-2-[(tert-butoxycarbonyl)amino]propionic acid, tert-Butyl [(1R)-2-(biphenyl-4-yl)-1-carboxyethyl]carbamate
  • (R)-a-(Boc-amino)-biphenyl-4-propanoic acid
  • N-Boc-3-(4-biphenylyl)-D-alani
  • (2R)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-(4-phenylphenyl)propanoic acid
  • Boc-p-phenyl-D-Phenylalanine≥ 99% (HPLC)
  • 4-Phenyl-D-phenylalanine, N-BOC protected
  • (R)-3-(biphenyl-4-yl)-2-(tert-butoxycarbonylamino)propanoic acid
  • (R)-N-ALPHA-T-BUTYLOXYCARBONYL-BIPHENYLALANINE
  • 3-(4-Biphenylyl)-N-(tert-butoxycarbonyl)-D-alanine
  • REF DUPL: Boc-D-4,4'-Biphenylalanine
  • (S)-2-AMino-3-(4'-((S)-2-(tert-butoxycarbonylaMino)-2-carboxyethyl)biphenyl-4-yl)propanoic acid
  • Boc-b-(4-biphenylyl)-D-Ala-OH, Boc-D-Bip-OH
  • BOC-D-4,4'-BIPHE-OH
  • [1,1'-Biphenyl]-4-propanoic acid, α-[[(1,1-dimethylethoxy)carbonyl]amino]-, (αR)-
  • (Tert-Butoxy)Carbonyl D-4,4'-Biphenylalanine
  • (R)-3-([1,1\'-biphenyl]-4-yl)-2-aminopropanoic acid hydrochloride
  • Sacubitril Impurity 55
  • SACUBITRIL(LCZ696)
  • -BIPHENYLALANINE
  • (2R)-3-{[1,1'-biphenyl]-4-yl}-2-{[(tert-butoxy)carbonyl]amino}propanoic acid
  • impurity 43
  • N-Boc-3-(4-biphenylyl)-D-alanine,95%
  • (2R)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-(4-phenylphenyl)propanoicaci
  • BOC-D-4,4'-BIPHENYLALANINE USP/EP/BP
  • BOC-D-4
  • LCZ-696 Impurity 80
  • Boc-d-4,4'-biphenylalanine
  • (R)-3-([1,1'-Biphenyl]-4-yl)-2-((tert-butoxycarbonyl)amino)propanoic acid
  • LCZ696 valsartan + sacubitril impurity 43
  • N-Boc-3-(4-biphenylyl)-D-alanine
  • 128779-47-5
  • C20H23NO4
  • Phenylalanine analogs and other aromatic alpha amino acids
  • Amino Acids
  • a-amino
  • Biphenyl & Diphenyl ether
  • Amino Acid Derivatives