COCHLIOQUINONE A

Product Name: COCHLIOQUINONE A
CAS No.: 32450-25-2
Chemical Name: COCHLIOQUINONE A
Synonyms: Luteoleersin;Cochlioquinone;Coclioquinone A;COCHLIOQUINONE A;(3R)-9-[(1S,2R,3S)-2-Acetyloxy-1,3-dimethylpentyl]-1,2,3,4aβ,5,6,6a,12,12aβ,12b-decahydro-12β-hydroxy-3α-(1-hydroxy-1-methylethyl)-6aα,12bα-dimethylpyrano[3,2-a]xanthene-8,11-dione;(2S,3R,4S)-2-[(3R,4aR,6aR,12S,12bR)-12-hydroxy-3-(2-hydroxypropan-2-yl)-6a,12b-dimethyl-8,11-dioxo-1,2,3,4a,5,6,12,12a-octahydropyrano[3,2-a]xanthen-9-yl]-4-methylhexan-3-yl] acetate;Pyrano[3,2-a]xanthene-8,11-dione, 9-[(1S,2R,3S)-2-(acetyloxy)-1,3-dimethylpentyl]-1,2,3,4a,5,6,6a,12,12a,12b-decahydro-12-hydroxy-3-(1-hydroxy-1-methylethyl)-6a,12b-dimethyl-, (3R,4aR,6aR,12S,12aS,12bR)-
CBNumber: CB0286529
Molecular Formula: C30H44O8
Formula Weight: 532.67
MOL File: 32450-25-2.mol

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COCHLIOQUINONE A Property

Melting point:: 135 °C
Boiling point:: 638.8±55.0 °C(Predicted)
Density: 1.21±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble
form: A yellow lyophilisate
pka: 11.57±0.70(Predicted)

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 19440
Product name: Cochlioquinone A
Purity: ≥99%
Packaging: 500μg
Price: $291
Updated: 2024/03/01

Cayman Chemical

Product number: 19440
Product name: Cochlioquinone A
Purity: ≥99%
Packaging: 2.5mg
Price: $1160
Updated: 2024/03/01

TRC

Product number: C633560
Product name: CochlioquinoneA
Packaging: 500μg
Price: $245
Updated: 2021/12/16

AK Scientific

Product number: 1051CB
Product name: CochlioquinoneA
Packaging: 2.5mg
Price: $1390
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: MTB0000899
Product name: COCHLIOQUINONE-A
Purity: 95.00%
Packaging: 5MG
Price: $497.63
Updated: 2021/12/16

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COCHLIOQUINONE A Chemical Properties,Usage,Production

Uses

Cochlioquinone A is the major component of a bioactive pigment isolated from Bipolaris leersia. Cochlioquinone A has recently been shown to be an antagonist of the human chemokine receptor, CCR5, in HIV-1,). Cochlioquinone A is anti-angiogenic and exhibits inhibitory activity against diacylglycerol acyltransferase and NADH-ubiquinone reductase.

Uses

Cochlioquinone A, a bioactive compound isolated from D. sacchari and Bipolaris sp., is an inhibitor of diacylglycerol kinase (DGK; Ki = 3.1 μM) and diacylglycerol acyltransferase (DGAT; IC50 = 5.6 μM). It has been shown to reduce the concentration of phosphatidic acid in T cell lymphoma with an IC50 value of 3 μM. It is also reported to compete with macrophage inflammatory protein-1α for binding to human CCR5 chemokine receptors with an IC50 value of 11 μM.[Cayman Chemical]

Uses

Cochlioquinone A is an antagonist of CCR5. Diacylglycerol kinase inhibitor.

Definition

ChEBI: Cochlioquinone A is a member of oxanes.

COCHLIOQUINONE A Preparation Products And Raw materials

Raw materials

Preparation Products

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COCHLIOQUINONE A Suppliers

China 13 France 1 Germany 1 South Korea 1 Switzerland 1 United Kingdom 5 United States 5 Global 27

Lynnchem

Tel: 86-(0)29-85992781 17792393971
Email: info@lynnchem.com
Country: China
ProdList: 4587
Advantage: 58

Novachemistry

Tel: 44-20819178-90 02081917890
Fax: (0)2080432064
Email: info@novachemistry.com
Country: United Kingdom
ProdList: 4381
Advantage: 58

Shanghai Hongye Biotechnology Co. Ltd

Tel: 400-9205774
Email: sales@glpbio.cn
Country: China
ProdList: 6777
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57423
Advantage: 58

BOC Sciences

Tel: 16314854226; +16314854226
Email: inquiry@bocsci.com
Country: United States
ProdList: 19741
Advantage: 58

Meng Cheng Technology (Shanghai) Co., LTD

Tel: 400-820-6829
Email: sales@mitachieve.com
Country: China
ProdList: 8860
Advantage: 58

Zhejiang Huida Biotech Co., LTD

Tel: 0571-89903882 13626641628
Email: jiangnan@huidabiotech.com
Country: China
ProdList: 3656
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8140
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Zhejiang Huida Biotech Co., LTD

Tel: 0571-0571-89903882 15990081639
Email: sunshixuan@huidabiotech.com
Country: China
ProdList: 3705
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24644
Advantage: 58

32450-25-2, COCHLIOQUINONE ARelated Search:

COCHLIOQUINONE B 4-(2,2,6-TRIMETHYLCYCLOHEXYL)-2-BUTANONE THYMOQUINONE GAMMA-TERPINENE CYCLOHEXYL VINYL ETHER COCHLIOQUINONE A

COCHLIOQUINONE A

(3R)-9-[(1S,2R,3S)-2-Acetyloxy-1,3-dimethylpentyl]-1,2,3,4aβ,5,6,6a,12,12aβ,12b-decahydro-12β-hydroxy-3α-(1-hydroxy-1-methylethyl)-6aα,12bα-dimethylpyrano[3,2-a]xanthene-8,11-dione

Luteoleersin

Coclioquinone A

Pyrano[3,2-a]xanthene-8,11-dione, 9-[(1S,2R,3S)-2-(acetyloxy)-1,3-dimethylpentyl]-1,2,3,4a,5,6,6a,12,12a,12b-decahydro-12-hydroxy-3-(1-hydroxy-1-methylethyl)-6a,12b-dimethyl-, (3R,4aR,6aR,12S,12aS,12bR)-

Cochlioquinone

(2S,3R,4S)-2-[(3R,4aR,6aR,12S,12bR)-12-hydroxy-3-(2-hydroxypropan-2-yl)-6a,12b-dimethyl-8,11-dioxo-1,2,3,4a,5,6,12,12a-octahydropyrano[3,2-a]xanthen-9-yl]-4-methylhexan-3-yl] acetate

32450-25-2

Antibiotic