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THYMOQUINONE

Product Name
THYMOQUINONE
CAS No.
490-91-5
Chemical Name
THYMOQUINONE
Synonyms
Thymoquinon;5-ISOPROPYL-2-METHYL-1,4-BENZOQUINONE;NSC 2228;THYMOQUINONE;thymolquinone;AURORA KA-6714;Semen Nigellae;Nigellae Semen。;Thymoquinone,99%;Thymoquinone >
CBNumber
CB1483664
Molecular Formula
C10H12O2
Formula Weight
164.2
MOL File
490-91-5.mol
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THYMOQUINONE Property

Melting point:
45-47 °C(lit.)
Boiling point:
230-232 °C(lit.)
Density 
1.0326 (rough estimate)
refractive index 
1.5155 (estimate)
Flash point:
219 °F
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly, Heated), Ethanol (Slightly), Methanol (Slightly)
form 
Solid
color 
Light Orange to Dark Yellow
Stability:
Light Sensitive
LogP
2.200
CAS DataBase Reference
490-91-5(CAS DataBase Reference)
EPA Substance Registry System
2,5-Cyclohexadiene-1,4-dione, 2-methyl-5-(1-methylethyl)- (490-91-5)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
GU5330000
HS Code 
29146990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
274666
Product name
Thymoquinone
Purity
≥98%
Packaging
1g
Price
$63.2
Updated
2024/03/01
Sigma-Aldrich
Product number
03416
Product name
Thymoquinone
Purity
analytical standard
Packaging
100mg
Price
$71
Updated
2024/03/01
TCI Chemical
Product number
T0795
Product name
Thymoquinone
Purity
>98.0%(GC)
Packaging
1g
Price
$47
Updated
2024/03/01
TCI Chemical
Product number
T0795
Product name
Thymoquinone
Purity
>98.0%(GC)
Packaging
5g
Price
$172
Updated
2024/03/01
Cayman Chemical
Product number
15039
Product name
Thymoquinone
Purity
≥98%
Packaging
1g
Price
$41
Updated
2024/03/01
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THYMOQUINONE Chemical Properties,Usage,Production

Description

Thymoquinone is an allergen In different cedar species.

Chemical Properties

orange to brown crystals

Uses

Thymoquinone is a phytochemical compound found in the plant Nigella sativa. Thymoquinone has antioxidant effects and has been shown to protect against heart, liver and kidney damage in animal studies, as well as having possible anti-cancer effects. Thymoquinone also has analgesic and anticonvulsant effects in animal models. Thymoquinone is an angiogenesis inhibitor. An IRAK1 inhibitor with in vivo and in vitro anti-inflammatory activities. Dyes and metabolites.

Definition

ChEBI: Thymoquinone is a member of the class of 1,4-benzoquinones that is 1,4-bezoquinone in which the hydrogens at positions 2 and 5 are replaced by methyl and isopropyl groups, respectively. It is a natural compound isolated from Nigella sativa which has demonstrated promising chemotherapeutic activity. It has a role as an anti-inflammatory agent, an antioxidant, an adjuvant, an antineoplastic agent, a cardioprotective agent, an antidepressant and a plant metabolite.

Contact allergens

Thymoquinone is an allergen in different cedar species, Cupressaceae family, such as incense cedar (Calocedrus decurrens Florin) used for pencils, chests or toys, and western cedar (Thuja plicata Donn.) as used for hard real- izations such as construction or boats.

Anticancer Research

The black cumin (Nigella sativa) that has a long history of medicinal use contains aphytochemical called thymoquinone (2-methyl-5-isopropyl-1,4-benzoquinone)(Padhye et al. 2008; Khan et al. 2011). In the regions of Southeastern Asia, Africa,Arab and the Mediterranean, the black cumin seeds have a notable history in traditionalmedicine practices. In ancient Egypt, Greece and Turkey, black cumin seedswere often used to treat many diseases and ailments (Padhye et al. 2008; Salih et al.2009; Khan et al. 2011; Ahmad et al. 2013). The Nigella sativa plant seeds and oilare used for medicinal purposes, and they are known for their hepatoprotective,renal-protective, antimicrobial, antidiabetic, anticancer, antihypertensive, analgesic,anti-inflammatory, immunomodulatory, spasmolytic, gastro-protective, bronchodilativeand antioxidant activities (Salih et al. 2009; Khan et al. 2011; Ahmad et al.2013). Recently, Barkat et al. (2017) reported that administration of thymoquinoneto MDA-MB-231 acts on cell cycle and inhibits progression from G1 to S phase bytargeting the cell cycle-related proteins such as cyclin D1, cyclin E and p27. It alsoexhibits histone deacetylase (HDAC) inhibitory effects, targets p21 and Maspin andinduces pro-apoptotic gene, Bax, and downregulates anti-apoptotic gene Bcl-2(Barkat et al. 2017).
Thymoquinone is the primary bioactive constituent of seed oil of Nigella sativa. It is a chemopreventiveagent and suppresses the proliferation of breast, colorectal, leukemia, osteosarcoma,ovarian, and pancreatic cancer cells. It suppresses TNF-inducedactivationof NF-κB in a time- and dose-dependent manner and the subsequent inhibition ofIκBα kinase activation, IκBα degradation, phosphorylation, p65 nuclear translocation,and phosphorylation. It specifically suppresses the nuclear p65 and recombinantp65 direct binding to DNA. It also downregulates the expression ofNF-κB-regulated antiapoptotic (survivin, IAP1, Bcl-xL, XIAP IAP2, Bcl-2), proliferative(cyclin D1, c-myc, and COX-2), and angiogenic (VEGF and MMP-9) geneproducts. It suppresses the activation of ERK and AKT pathways and blocks in vitroand in vivo angiogenesis (Aggarwal et al. 2008).

Anticancer Research

Thymoquinone acts on cell cycleand inhibits progression from G1 toS phase by targeting the cellcycle-related proteins such as cyclinD1, cyclin E and p27.It also exhibits histone deacetylase(HDAC) inhibitory effects andtargets p21 and Maspin.Induces pro-apoptotic gene, Bax,and downregulates anti-apoptoticgene Bcl-2
Barkat et al.(2017)

THYMOQUINONE Preparation Products And Raw materials

Raw materials

Preparation Products

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THYMOQUINONE Suppliers

jinanboqiBioCD
Tel
0531-85989961 18560037790
Email
78986087@qq.com
Country
China
ProdList
12
Advantage
58
Shanghai Yihe Biological Technology Co., Ltd.
Tel
17721395025
Fax
021-68882955
Email
2423903095@qq.com
Country
China
ProdList
3990
Advantage
58
Shandong Haiwo Biological Technology Co., Ltd.
Tel
0531-87586188 13046003282
Fax
0531-87586188
Email
3473674613@qq.com
Country
China
ProdList
54
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
Advantage
61
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14103
Advantage
59
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
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View Lastest Price from THYMOQUINONE manufacturers

HangZhou RunYan Pharma Technology Co.,LTD.
Product
Thymoquinone 490-91-5
Price
US $0.00-0.00/g
Min. Order
10000g
Purity
99% HPLC
Supply Ability
1000kg
Release date
2024-11-19
HebeiShuoshengImportandExportco.,Ltd
Product
THYMOQUINONE 490-91-5
Price
US $6.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000KG/Month
Release date
2024-08-02
Changsha Staherb Natural Ingredients Co., Ltd.
Product
THYMOQUINONE 490-91-5
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
≥98% UV
Supply Ability
1000kg
Release date
2022-10-21

490-91-5, THYMOQUINONERelated Search:


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  • 4-dione,5-isopropyl-2-methyl-5-cyclohexadiene-1
  • 5-Isopropyl-2-methyl-p-benzoquinone
  • p-Cymene-2,5-dione
  • thymolquinone
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  • TIMTEC-BB SBB008296
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  • 2-METHYL-5-ISO-PROPYLBENZOQUINONE
  • 5-ISOPROPYL-2-METHYL-1,4-BENZOQUINONE
  • AURORA KA-6714
  • 2-isopropyl-5-methyl-p-benzoquinone
  • 2-METHYL-5-(1-METHYLETHYL)-2,5-CYCLOHEXANDIENE-1,4-DIONE
  • Thymoquinone,99%
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  • Thymoquinone, 2-Methyl-5-(prop-2-yl)cyclohexa-2,5-diene-1,4-dione
  • 5-Isopropyl-2-methyl-1,4-benzoquinone p-Mentha-3,6-diene-2,5-dione
  • NSC 2228
  • 2,5-Cyclohexadiene-1,4-dione,2-Methyl-5-(1-Methylethyl)-
  • 2-isopropyl-5-Methylcyclohexa-2,5-diene-1,4-dione
  • Semen Nigellae
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  • 2-Isopropyl-5-methylbenzoquinone
  • 2-Methyl-5-(1-methylethyl)-2,5-cyclohexadiene-1,4-dione
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  • 2-Methyl-5-isopropyl-p-benzoquinone
  • 2-methyl-5-propan-2-ylcyclohexa-2,5-diene-1,4-dione
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  • Nigellae Semen extract
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