THYMOQUINONE
- Product Name
- THYMOQUINONE
- CAS No.
- 490-91-5
- Chemical Name
- THYMOQUINONE
- Synonyms
- Thymoquinon;5-ISOPROPYL-2-METHYL-1,4-BENZOQUINONE;NSC 2228;THYMOQUINONE;thymolquinone;AURORA KA-6714;Semen Nigellae;Nigellae Semen。;Thymoquinone,99%;Thymoquinone >
- CBNumber
- CB1483664
- Molecular Formula
- C10H12O2
- Formula Weight
- 164.2
- MOL File
- 490-91-5.mol
THYMOQUINONE Property
- Melting point:
- 45-47 °C(lit.)
- Boiling point:
- 230-232 °C(lit.)
- Density
- 1.0326 (rough estimate)
- refractive index
- 1.5155 (estimate)
- Flash point:
- 219 °F
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly, Heated), Ethanol (Slightly), Methanol (Slightly)
- form
- Solid
- color
- Light Orange to Dark Yellow
- Stability:
- Light Sensitive
- LogP
- 2.200
- CAS DataBase Reference
- 490-91-5(CAS DataBase Reference)
- EPA Substance Registry System
- 2,5-Cyclohexadiene-1,4-dione, 2-methyl-5-(1-methylethyl)- (490-91-5)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-36
- WGK Germany
- 3
- RTECS
- GU5330000
- HS Code
- 29146990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 274666
- Product name
- Thymoquinone
- Purity
- ≥98%
- Packaging
- 1g
- Price
- $63.2
- Updated
- 2024/03/01
- Product number
- 03416
- Product name
- Thymoquinone
- Purity
- analytical standard
- Packaging
- 100mg
- Price
- $71
- Updated
- 2024/03/01
- Product number
- T0795
- Product name
- Thymoquinone
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $47
- Updated
- 2024/03/01
- Product number
- T0795
- Product name
- Thymoquinone
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $172
- Updated
- 2024/03/01
- Product number
- 15039
- Product name
- Thymoquinone
- Purity
- ≥98%
- Packaging
- 1g
- Price
- $41
- Updated
- 2024/03/01
THYMOQUINONE Chemical Properties,Usage,Production
Description
Thymoquinone is an allergen In different cedar species.
Chemical Properties
orange to brown crystals
Uses
Thymoquinone is a phytochemical compound found in the plant Nigella sativa. Thymoquinone has antioxidant effects and has been shown to protect against heart, liver and kidney damage in animal studies, as well as having possible anti-cancer effects. Thymoquinone also has analgesic and anticonvulsant effects in animal models. Thymoquinone is an angiogenesis inhibitor. An IRAK1 inhibitor with in vivo and in vitro anti-inflammatory activities. Dyes and metabolites.
Definition
ChEBI: Thymoquinone is a member of the class of 1,4-benzoquinones that is 1,4-bezoquinone in which the hydrogens at positions 2 and 5 are replaced by methyl and isopropyl groups, respectively. It is a natural compound isolated from Nigella sativa which has demonstrated promising chemotherapeutic activity. It has a role as an anti-inflammatory agent, an antioxidant, an adjuvant, an antineoplastic agent, a cardioprotective agent, an antidepressant and a plant metabolite.
Contact allergens
Thymoquinone is an allergen in different cedar species, Cupressaceae family, such as incense cedar (Calocedrus decurrens Florin) used for pencils, chests or toys, and western cedar (Thuja plicata Donn.) as used for hard real- izations such as construction or boats.
Anticancer Research
The black cumin (Nigella sativa) that has a long history of medicinal use contains aphytochemical called thymoquinone (2-methyl-5-isopropyl-1,4-benzoquinone)(Padhye et al. 2008; Khan et al. 2011). In the regions of Southeastern Asia, Africa,Arab and the Mediterranean, the black cumin seeds have a notable history in traditionalmedicine practices. In ancient Egypt, Greece and Turkey, black cumin seedswere often used to treat many diseases and ailments (Padhye et al. 2008; Salih et al.2009; Khan et al. 2011; Ahmad et al. 2013). The Nigella sativa plant seeds and oilare used for medicinal purposes, and they are known for their hepatoprotective,renal-protective, antimicrobial, antidiabetic, anticancer, antihypertensive, analgesic,anti-inflammatory, immunomodulatory, spasmolytic, gastro-protective, bronchodilativeand antioxidant activities (Salih et al. 2009; Khan et al. 2011; Ahmad et al.2013). Recently, Barkat et al. (2017) reported that administration of thymoquinoneto MDA-MB-231 acts on cell cycle and inhibits progression from G1 to S phase bytargeting the cell cycle-related proteins such as cyclin D1, cyclin E and p27. It alsoexhibits histone deacetylase (HDAC) inhibitory effects, targets p21 and Maspin andinduces pro-apoptotic gene, Bax, and downregulates anti-apoptotic gene Bcl-2(Barkat et al. 2017).
Thymoquinone is the primary bioactive constituent of seed oil of Nigella sativa. It is a chemopreventiveagent and suppresses the proliferation of breast, colorectal, leukemia, osteosarcoma,ovarian, and pancreatic cancer cells. It suppresses TNF-inducedactivationof NF-κB in a time- and dose-dependent manner and the subsequent inhibition ofIκBα kinase activation, IκBα degradation, phosphorylation, p65 nuclear translocation,and phosphorylation. It specifically suppresses the nuclear p65 and recombinantp65 direct binding to DNA. It also downregulates the expression ofNF-κB-regulated antiapoptotic (survivin, IAP1, Bcl-xL, XIAP IAP2, Bcl-2), proliferative(cyclin D1, c-myc, and COX-2), and angiogenic (VEGF and MMP-9) geneproducts. It suppresses the activation of ERK and AKT pathways and blocks in vitroand in vivo angiogenesis (Aggarwal et al. 2008).
Anticancer Research
Thymoquinone acts on cell cycleand inhibits progression from G1 toS phase by targeting the cellcycle-related proteins such as cyclinD1, cyclin E and p27.It also exhibits histone deacetylase(HDAC) inhibitory effects andtargets p21 and Maspin.Induces pro-apoptotic gene, Bax,and downregulates anti-apoptoticgene Bcl-2
Barkat et al.(2017)
THYMOQUINONE Preparation Products And Raw materials
Raw materials
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View Lastest Price from THYMOQUINONE manufacturers
- Product
- THYMOQUINONE 490-91-5
- Price
- US $6.00/KG
- Min. Order
- 1KG
- Purity
- More than 99%
- Supply Ability
- 2000KG/Month
- Release date
- 2024-04-28
- Product
- THYMOQUINONE 490-91-5
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- ≥98% UV
- Supply Ability
- 1000kg
- Release date
- 2022-10-21
- Product
- Thymoquinone 490-91-5
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 1% 5% 10% 20% 98% 99%
- Supply Ability
- 1000 kg
- Release date
- 2024-04-21