SUCCINIMIDYL 6-BOC-HYDRAZINONICOTINATE

Product Name: SUCCINIMIDYL 6-BOC-HYDRAZINONICOTINATE
CAS No.: 133081-26-2
Chemical Name: SUCCINIMIDYL 6-BOC-HYDRAZINONICOTINATE
Synonyms: 2,5-Dioxopyrrolidin-1-yl 6-(2-(tert-butoxycarbonyl)hydrazinyl)nicotinate;SUCCINIMIDYL-N-BOC-HYNIC;6-BOC-HYDRAZINOPYRIDINE-3-NHS;SUCCINIMIDYL 6-BOC-HYDRAZINONICOTINATE;Succinimidyl 6-(2-Boc-hydrazino)nicotinate;6-(2-Boc-hydrazinyl)-3-pyridinecarboxylic acid 2,5-dioxo-1-pyrrolidinyl ester;N'-(5-[2-(2,5-DIOXO-PYRROLIDIN-1-YLOXY)-ACETYL]-PYRIDIN-2-YL)-HYDRAZINECARBOXYLIC ACID TERT-BUTYL ESTER;3-Pyridinecarboxylicacid, 6-[1-[(1,1-dimethylethoxy)carbonyl]hydrazinyl]-, 2,5-dioxo-1-pyrrolidinylester;HYDRAZINECARBOXYLIC ACID, 2-[5-[[(2,5-DIOXO-1-PYRROLIDINYL)OXY]CARBONYL]-2-PYRIDINYL]-, 1,1-DIMETHYLETHYL ESTER;6-Boc-hydrazinopyridine-3-NHS, Succinimidyl-N-Boc-Hynic, N''-{5-[2-(2,5-Dioxo-pyrrolidin-1-yloxy)-acetyl]-pyridin-2-yl}-hydrazinecarboxylic acid tert-butyl ester
CBNumber: CB0294593
Molecular Formula: C15H18N4O6
Formula Weight: 350.33
MOL File: 133081-26-2.mol

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SUCCINIMIDYL 6-BOC-HYDRAZINONICOTINATE Property

Melting point:: 168-171 °C
Density: 1.40±0.1 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
pka: 9.47±0.43(Predicted)
Appearance: White to off-white Solid
CAS DataBase Reference: 133081-26-2

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Matrix Scientific

Product number: 092968
Product name: 2,5-Dioxopyrrolidin-1-yl 6-(2-(tert-butoxycarbonyl)-hydrazinyl)nicotinate
Purity: 95+%
Packaging: 250mg
Price: $482
Updated: 2021/12/16

Matrix Scientific

Product number: 092968
Product name: 2,5-Dioxopyrrolidin-1-yl 6-(2-(tert-butoxycarbonyl)-hydrazinyl)nicotinate
Purity: 95+%
Packaging: 500mg
Price: $743
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 33384
Product name: Succinimidyl6-BOC-hydrazinonicotinate
Purity: >95%
Packaging: 50mg
Price: $950
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0290713
Product name: SUCCINIMIDYL-N-BOC-HYNIC
Purity: 98.00%
Packaging: 0.5G
Price: $1027.5
Updated: 2021/12/16

Matrix Scientific

Product number: 092968
Product name: 2,5-Dioxopyrrolidin-1-yl 6-(2-(tert-butoxycarbonyl)-hydrazinyl)nicotinate
Purity: 95+%
Packaging: 1g
Price: $1143
Updated: 2021/12/16

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SUCCINIMIDYL 6-BOC-HYDRAZINONICOTINATE Chemical Properties,Usage,Production

Chemical Properties

Colourless crystals

Synthesis

123-56-8

133081-25-1

133081-26-2

To a DMF solution of 6-[2-(tert-butoxycarbonyl)hydrazinyl]nicotinic acid (0.57 g, 2.26 mmol) and butanediimide (0.27 g, 2.26 mmol) was added DCC (0.47 g, 2.26 mmol), and the reaction mixture gradually became turbid. After 1 hour of reaction, stirring was continued for 16 hours. After completion of the reaction, the mixture was concentrated to dryness and the residue was purified by silica gel column chromatography using ethyl acetate as eluent to afford the white solid product 2,5-dioxopyrrolidin-1-yl 6-(2-(tert-butoxycarbonyl)-hydrazino)nicotinic acid ester (0.66 g, 84% yield). Melting point: 174°C. IR (ATR, cm^-1): 3321, 2979, 1729, 1594, 1365, 1240, 1198, 1068, 974, 641. 1H NMR (DMSO-d6): δ 9.46 (s, 1H), 9.20 (s, 1H), 8.76 (d, 1H, J = 2.1Hz), 8.11 (d, 1H, J = 8.1Hz), 6.67 (d, 1H, J = 9Hz), 2.88 (s, 4H), 1.44 (s, 9H).13C NMR (DMSO-d6): δ 172.8, 170.5, 160.9, 155.4, 151.8, 110.0, 79.6, 28.0, 25.5.MS ( ESI+): m/z 351.00 [M + H]+. HRMS (ESI+): m/z [M + H]+ Calculated value for C15H19N4O6 is 351.1305, measured value is 351.1299.

References

[1] Letters in Organic Chemistry, 2014, vol. 11, # 3, p. 208 - 214

SUCCINIMIDYL 6-BOC-HYDRAZINONICOTINATE Preparation Products And Raw materials

Raw materials

Preparation Products

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SUCCINIMIDYL 6-BOC-HYDRAZINONICOTINATE Suppliers

China 36 Germany 2 India 2 United States 6 Global 46

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133081-26-2, SUCCINIMIDYL 6-BOC-HYDRAZINONICOTINATERelated Search:

SUCCINIMIDYL 6-BOC-HYDRAZINONICOTINATE NIC-OSU 6-[2-(tert-Butoxycarbonyl)hydrazinyl]nicotinic acid 6-HYDRAZINONICOTINIC ACID

SUCCINIMIDYL-N-BOC-HYNIC

SUCCINIMIDYL 6-BOC-HYDRAZINONICOTINATE

N'-(5-[2-(2,5-DIOXO-PYRROLIDIN-1-YLOXY)-ACETYL]-PYRIDIN-2-YL)-HYDRAZINECARBOXYLIC ACID TERT-BUTYL ESTER

6-BOC-HYDRAZINOPYRIDINE-3-NHS

6-Boc-hydrazinopyridine-3-NHS, Succinimidyl-N-Boc-Hynic, N''-{5-[2-(2,5-Dioxo-pyrrolidin-1-yloxy)-acetyl]-pyridin-2-yl}-hydrazinecarboxylic acid tert-butyl ester

2,5-Dioxopyrrolidin-1-yl 6-(2-(tert-butoxycarbonyl)hydrazinyl)nicotinate

HYDRAZINECARBOXYLIC ACID, 2-[5-[[(2,5-DIOXO-1-PYRROLIDINYL)OXY]CARBONYL]-2-PYRIDINYL]-, 1,1-DIMETHYLETHYL ESTER

3-Pyridinecarboxylicacid, 6-[1-[(1,1-dimethylethoxy)carbonyl]hydrazinyl]-, 2,5-dioxo-1-pyrrolidinylester

Succinimidyl 6-(2-Boc-hydrazino)nicotinate

6-(2-Boc-hydrazinyl)-3-pyridinecarboxylic acid 2,5-dioxo-1-pyrrolidinyl ester

133081-26-2

C15H18N4O6