6-HYDRAZINONICOTINIC ACID
- Product Name
- 6-HYDRAZINONICOTINIC ACID
- CAS No.
- 133081-24-0
- Chemical Name
- 6-HYDRAZINONICOTINIC ACID
- Synonyms
- MS-3627;6-Hydrazinicotinic acid;HYDRALINK 6-HNA REAGENT;6-HydrazinonicotinicAci;6-HYDRAZINONICOTINIC ACID;6-Hydrazinylnicotinic acid;HYDRALINK(TM) 6-HNA REAGENT;6-hydrazineylnicotinic acid;6-HYDRAZINO-NICOTINIC ACID, 98+%;6-Hydrazino-3-pyridinecarboxylic acid
- CBNumber
- CB1316892
- Molecular Formula
- C6H7N3O2
- Formula Weight
- 153.14
- MOL File
- 133081-24-0.mol
6-HYDRAZINONICOTINIC ACID Property
- Melting point:
- 0°C
- Boiling point:
- 0°C
- Density
- 1.51±0.1 g/cm3(Predicted)
- Flash point:
- 0°C
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- solubility
- Aqueous Base (Slightly, Heated, Sonicated)
- form
- Solid
- pka
- 4.72±0.20(Predicted)
- color
- Pale Yellow to Light Yellow
- InChI
- InChI=1S/C6H7N3O2/c7-9-5-2-1-4(3-8-5)6(10)11/h1-3H,7H2,(H,8,9)(H,10,11)
- InChIKey
- HBBSDZXXUIHKJE-UHFFFAOYSA-N
- SMILES
- C1=NC(NN)=CC=C1C(O)=O
- CAS DataBase Reference
- 133081-24-0
Safety
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 22-24/25
- HazardClass
- IRRITANT
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- H716503
- Product name
- 6-Hydrazinonicotinicacid
- Packaging
- 10g
- Price
- $200
- Updated
- 2021/12/16
- Product number
- 280145
- Product name
- 6-Hydrazino-3-pyridinecarboxylic acid
- Packaging
- 250mg
- Price
- $340
- Updated
- 2021/12/16
- Product number
- X9846
- Product name
- 6-Hydrazinicotinicacid
- Packaging
- 5g
- Price
- $66
- Updated
- 2021/12/16
- Product number
- 065600
- Product name
- 6-Hydrazinonicotinic acid
- Packaging
- 5g
- Price
- $100
- Updated
- 2021/12/16
- Product number
- 065600
- Product name
- 6-Hydrazinonicotinic acid
- Packaging
- 25g
- Price
- $300
- Updated
- 2021/12/16
6-HYDRAZINONICOTINIC ACID Chemical Properties,Usage,Production
Synthesis
5326-23-8
133081-24-0
Example 72: Synthesis of 3-oxo-2,3-dihydro-[1,2,4]triazolo[4,3-a]pyridine-6-carbonyl chloride: 1. 6-Chloronicotinic acid (20 g, 127 mmol) was used as raw material, which was dissolved in 200 mL of ethanol and hydrazine hydrate (14.8 mL, 317 mmol) was added. The reaction mixture was refluxed overnight, cooled to room temperature and precipitated as a solid, which was collected by filtration and washed with petroleum ether/ethyl acetate (2:1) to give 18 g of 6-hydrazinonicotinic acid as a yellow solid (yield: 91%).1H NMR (DMSO, 400 MHz) δ: 8.52 (s, 1H), 7.88 (dd, J = 2.0 Hz, 8.8 Hz, 1H), 6.63 (d, J = 8.8 Hz, 1H). 2. 6-Hydrazinonicotinic acid (18 g, 117 mmol) was suspended in 100 mL of anhydrous tetrahydrofuran, anhydrous pyridine (23 g, 293 mmol) was added, and after stirring at room temperature for 15 min, bis(trichloromethyl) carbonate (80 g, 270 mmol) was slowly added. The reaction mixture was stirred at room temperature overnight, methanol was added and stirring was continued for 15 h. A solid was precipitated, which was collected by filtration and washed with petroleum ether/ethyl acetate (1:1) to afford 20 g of dimethyl 3-oxo-[1,2,4]triazolo[4,3-a]pyridine-2,6(3H)-dicarboxylate.1H NMR (CDCl3, 400 MHz) δ: 3.95 (s, 3H) , 4.13 (s, 1H), 7.13 (dd, J = 1.6 Hz, 10 Hz, 1H), 7.71 (dd, J = 1.6 Hz, 10 Hz, 1H), 8.55 (t, J = 2 Hz, 1H). 3. 3-Oxo-[1,2,4]triazolo[4,3-a]pyridine-2,6(3H)-dicarboxylic acid dimethyl ester (10 g, 40 mmol) was dissolved in 60 mL of tetrahydrofuran, 10 mL of water and LiOH-H2O (4.8 g, 114 mmol) were added, and after stirring at room temperature for 6 h, the tetrahydrofuran was removed by vacuum concentration, and the tetrahydrofuran was adjusted to pH 2 by adding 1 mL of HCl solution. The pH was adjusted to 2. A solid was precipitated and collected to give 11 g of 3-oxo-2,3-dihydro-[1,2,4]triazolo[4,3-a]pyridine-6-carboxylic acid, which was used directly in the next step.1H NMR (DMSO, 400 MHz) δ: 7.23 (d, J = 10 Hz, 1H), 7.48 (dd, J = 1.6 Hz, 10 Hz, 1H), 8.25 (s, 1H), 8.25 (s, 1H), 8.25 (s, 1H) and 8.25 (s, 1H). 8.25 (s, 1H), 9.13 (s, 1H), 12.89 (s, 1H). 4. 3-Oxo-2,3-dihydro-[1,2,4]triazolo[4,3-a]pyridine-6-carboxylic acid (3 g, 16.8 mmol) was dissolved in 60 mL of anhydrous dichloromethane, oxalyl chloride (8.8 g, 74 mmol) and 1 mL of DMF were added, and the mixture was concentrated after stirring for 6 hours at room temperature to give 3 g of the title compound, 3-oxo-2,3-dihydro-[1 ,2,. 4]triazolo[4,3-a]pyridine-6-carbonyl chloride as a gray solid, which was used directly in the next reaction.
References
[1] Letters in Organic Chemistry, 2014, vol. 11, # 3, p. 208 - 214
[2] Patent: WO2010/96722, 2010, A1. Location in patent: Page/Page column 54-55
[3] Polish Journal of Chemistry, 2004, vol. 78, # 7, p. 951 - 959
[4] Patent: WO2017/177144, 2017, A1. Location in patent: Page/Page column 33; 39
[5] Pharmazie, 2006, vol. 61, # 4, p. 269 - 273
6-HYDRAZINONICOTINIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-HYDRAZINONICOTINIC ACID manufacturers
- Product
- 6-hydrazinonicotinic acid 133081-24-0
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1000KGS
- Release date
- 2024-11-12
- Product
- 6-Hydrazinonicotinic acid 133081-24-0
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98.9%
- Supply Ability
- 100 tons
- Release date
- 2022-01-25
- Product
- 6-HYDRAZINONICOTINIC ACID 133081-24-0
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-26