ChemicalBook > CAS DataBase List > 2-HYDROXYSACLOFEN
2-HYDROXYSACLOFEN
- Product Name
- 2-HYDROXYSACLOFEN
- CAS No.
- 117354-64-0
- Chemical Name
- 2-HYDROXYSACLOFEN
- Synonyms
- 2-Oh-saclofen;HYDROXYSACLOFEN;2-HYDROXYSACLOFEN;2-HYDROXYSACLOFEN, >99%;2-Hydroxysaclofen solid;2 Hydroxysaclofen,2Hydroxysaclofen;2-Hydroxysaclofen >=98% (TLC), solid;2-HYDROXYSACLOFEN ISO 9001：2015 REACH;2-HYDROXYSACLOFEN GABA(B) RECEPTOR ANTA;3-amino-2-(4-chlorophenyl)-2-hydroxy-*propanesulf
- CBNumber
- CB0299578
- Molecular Formula
- C9H12ClNO4S
- Formula Weight
- 265.71
- MOL File
- 117354-64-0.mol
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2-HYDROXYSACLOFEN Property
- Melting point:
- 267-269 °C
- RTECS
- DA0359200
- storage temp.
- 2-8°C
- solubility
- H2O: 1 mg/mL
- form
- solid
- color
- white
- Water Solubility
- Soluble in water at 1mg/ml. Also soluble in DMSO, 0.1M HCl and methanol
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Safety
- Hazard Codes
- C
- Risk Statements
- 34
- Safety Statements
- 26-27-36/37/39-45
- RIDADR
- UN 1759 8/PG 3
- WGK Germany
- 3
- HazardClass
- 8
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- A6566
- Product name
- 2-Hydroxysaclofen
- Purity
- ≥98% (TLC), solid
- Packaging
- 2.5mg
- Price
- $138.7
- Updated
- 2025/07/31
Tocris
- Product number
- 0245
- Product name
- 2-Hydroxysaclofen
- Packaging
- 50
- Price
- $878
- Updated
- 2021/12/16
Tocris
- Product number
- 0245
- Product name
- 2-Hydroxysaclofen
- Packaging
- 10
- Price
- $214
- Updated
- 2021/12/16
Usbiological
- Product number
- 254361
- Product name
- 2-Hydroxysaclofen
- Packaging
- 10mg
- Price
- $495
- Updated
- 2021/12/16
TRC
- Product number
- H953138
- Product name
- 2-Hydroxysaclofen
- Packaging
- 5mg
- Price
- $395
- Updated
- 2021/12/16
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2-HYDROXYSACLOFEN Chemical Properties,Usage,Production
Uses
2-Hydroxysaclofen is a GABA-B receptor antagonist in the ventral tegmental area and may play a role in the mechanisms of cocaine usage. Affects specific acute nicotine responses in mice, abolishing hypolocomotion and increasing antinociception.
Definition
ChEBI: 3-amino-2-(4-chlorophenyl)-2-hydroxy-1-propanesulfonic acid is an organochlorine compound.
Biological Activity
Selective antagonist at GABA B receptors.
in vivo
2-Hydroxysaclofen (0.25-1 mg/kg; IP; single dosage) abolishes nicotine hypolocomotor effects and increases the antinociceptive effects of nicotine[1].
2-Hydroxysaclofen (0.3-3 mg/kg; IP; single dosage) reduces the effects of Baclofen (a GABA receptor agonist) on d-amphetamine-induced discriminative cue[2].
2-Hydroxysaclofen (0-100 μg/2 μl; ICV; single dosage) produces a rapid elevation in the serum LH concentration in the estrogen-primed ovariectomized rat[3].
| Animal Model: | Male Swiss Webster mice (22-24 g; treated with 3 mg/kg nicotine)[1] |
| Dosage: | 0.25, 0.5 and 1 mg/kg |
| Administration: | IP; single dosage; after 10 or 45 min of nicotine administration |
| Result: | Abolished nicotine hypolocomotor effects at 1 mg/kg, and increased the antinociceptive effects of nicotine at 1 mg/kg. |
| Animal Model: | Male Wistar rats[2] |
| Dosage: | 0.3, 1 and 3 mg/kg |
| Administration: | IP; single dosage |
| Result: | Reduced the effects of Baclofen on d-amphetamine-induced discriminative cue. |
| Animal Model: | Female Wistar rats (8 weeks)[3] |
| Dosage: | 0, 20, 50 or 100 μg/2 μL |
| Administration: | ICV; single dosage |
| Result: | Produced a rapid elevation in the serum LH concentration in the estrogen-primed ovariectomized rat with a dose-dependent manner, and the peak LH values were observed 10 min after the injection. The effect was dose-dependent, as 0 or 20 μg of the antagonist was ineffective while a pronounced effect was observed after the injection of 50 or 100 μg. |
storage
Store at RT
2-HYDROXYSACLOFEN Preparation Products And Raw materials
Raw materials
Preparation Products
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2-HYDROXYSACLOFEN Suppliers
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View Lastest Price from 2-HYDROXYSACLOFEN manufacturers
Shaanxi Dideu Medichem Co. Ltd
- Product
- 2-Hydroxysaclofen 117354-64-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%+
- Supply Ability
- 100 tons
- Release date
- 2019-12-31
117354-64-0, 2-HYDROXYSACLOFENRelated Search:
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