2-HYDROXYSACLOFEN

Product Name: 2-HYDROXYSACLOFEN
CAS No.: 117354-64-0
Chemical Name: 2-HYDROXYSACLOFEN
Synonyms: 2-Oh-saclofen;HYDROXYSACLOFEN;2-HYDROXYSACLOFEN;2-HYDROXYSACLOFEN, >99%;2-Hydroxysaclofen solid;2 Hydroxysaclofen,2Hydroxysaclofen;2-Hydroxysaclofen >=98% (TLC), solid;2-HYDROXYSACLOFEN ISO 9001：2015 REACH;2-HYDROXYSACLOFEN GABA(B) RECEPTOR ANTA;3-amino-2-(4-chlorophenyl)-2-hydroxy-*propanesulf
CBNumber: CB0299578
Molecular Formula: C9H12ClNO4S
Formula Weight: 265.71
MOL File: 117354-64-0.mol

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2-HYDROXYSACLOFEN Property

Melting point:: 267-269 °C
RTECS: DA0359200
storage temp.: 2-8°C
solubility: H₂O: 1 mg/mL
form: solid
color: white
Water Solubility: Soluble in water at 1mg/ml. Also soluble in DMSO, 0.1M HCl and methanol
InChI: 1S/C9H12ClNO4S/c10-8-3-1-7(2-4-8)9(12,5-11)6-16(13,14)15/h1-4,12H,5-6,11H2,(H,13,14,15)
InChIKey: WBSMZVIMANOCNX-UHFFFAOYSA-N
SMILES: NCC(O)(CS(O)(=O)=O)c1ccc(Cl)cc1

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Safety

Hazard Codes: C
Risk Statements: 34
Safety Statements: 26-27-36/37/39-45
RIDADR: UN 1759 8/PG 3
WGK Germany: 3
HazardClass: 8
Storage Class: 8A - Combustible corrosive hazardous materials
Hazard Classifications: Skin Corr. 1B

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A6566
Product name: 2-Hydroxysaclofen
Purity: ≥98% (TLC), solid
Packaging: 2.5mg
Price: $138.7
Updated: 2025/07/31

Tocris

Product number: 0245
Product name: 2-Hydroxysaclofen
Packaging: 50
Price: $878
Updated: 2021/12/16

Tocris

Product number: 0245
Product name: 2-Hydroxysaclofen
Packaging: 10
Price: $214
Updated: 2021/12/16

Usbiological

Product number: 254361
Product name: 2-Hydroxysaclofen
Packaging: 10mg
Price: $495
Updated: 2021/12/16

TRC

Product number: H953138
Product name: 2-Hydroxysaclofen
Packaging: 5mg
Price: $395
Updated: 2021/12/16

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2-HYDROXYSACLOFEN Chemical Properties,Usage,Production

Uses

2-Hydroxysaclofen is a GABA-B receptor antagonist in the ventral tegmental area and may play a role in the mechanisms of cocaine usage. Affects specific acute nicotine responses in mice, abolishing hypolocomotion and increasing antinociception.

Definition

ChEBI: 3-amino-2-(4-chlorophenyl)-2-hydroxy-1-propanesulfonic acid is an organochlorine compound.

Biological Activity

Selective antagonist at GABA B receptors.

in vivo

2-Hydroxysaclofen (0.25-1 mg/kg; IP; single dosage) abolishes nicotine hypolocomotor effects and increases the antinociceptive effects of nicotine^[1].
2-Hydroxysaclofen (0.3-3 mg/kg; IP; single dosage) reduces the effects of Baclofen (a GABA receptor agonist) on d-amphetamine-induced discriminative cue^[2].
2-Hydroxysaclofen (0-100 μg/2 μl; ICV; single dosage) produces a rapid elevation in the serum LH concentration in the estrogen-primed ovariectomized rat^[3].

Animal Model:	Male Swiss Webster mice (22-24 g; treated with 3 mg/kg nicotine)^[1]
Dosage:	0.25, 0.5 and 1 mg/kg
Administration:	IP; single dosage; after 10 or 45 min of nicotine administration
Result:	Abolished nicotine hypolocomotor effects at 1 mg/kg, and increased the antinociceptive effects of nicotine at 1 mg/kg.

Animal Model:	Male Wistar rats^[2]
Dosage:	0.3, 1 and 3 mg/kg
Administration:	IP; single dosage
Result:	Reduced the effects of Baclofen on d-amphetamine-induced discriminative cue.

Animal Model:	Female Wistar rats (8 weeks)^[3]
Dosage:	0, 20, 50 or 100 μg/2 μL
Administration:	ICV; single dosage
Result:	Produced a rapid elevation in the serum LH concentration in the estrogen-primed ovariectomized rat with a dose-dependent manner, and the peak LH values were observed 10 min after the injection. The effect was dose-dependent, as 0 or 20 μg of the antagonist was ineffective while a pronounced effect was observed after the injection of 50 or 100 μg.

storage

Store at RT

2-HYDROXYSACLOFEN Preparation Products And Raw materials

Raw materials

Preparation Products

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2-HYDROXYSACLOFEN Suppliers

China 29 Europe 1 Germany 3 Switzerland 1 United Kingdom 5 United States 9 USA 1 Global 49

J & K SCIENTIFIC LTD.

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Energy Chemical

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MedBioPharmaceutical Technology Inc

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TargetMol Chemicals Inc.

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View Lastest Price from 2-HYDROXYSACLOFEN manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 2-Hydroxysaclofen 117354-64-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%+
Supply Ability: 100 tons
Release date: 2019-12-31

117354-64-0, 2-HYDROXYSACLOFENRelated Search:

5-hydroxysaclofen 1-AMINO-2-METHYL-PROPAN-2-OL HCL P-CHLORO-BETA-METHYL-PHENETHYLAMINE HYDROCHLORIDE 2-HYDROXYSACLOFEN 1-AMINO-2-(4-CHLORO-PHENYL)-PROPAN-2-OL SACLOFEN 1-AMINO-2-PHENYL-PROPAN-2-OL 2-Amino-1-(4-chlorophenyl)ethan-1-ol Ammonium 2-hydroxyethanesulphonate

HYDROXYSACLOFEN

3-amino-2-(4-chlorophenyl)-2-hydroxy-*propanesulf

2-HYDROXYSACLOFEN GABA(B) RECEPTOR ANTA

3-AMINO-2-(4-CHLOROPHENYL)-2-HYDROXY-PRO PANESULFON

2-HYDROXYSACLOFEN, >99%

3-Amino-2-(4-chlorophenyl)-2-hydroxypropane-1-sulfonic acid

3-Amino-2-hydroxy-2-(4-chlorophenyl)propane-1-sulfonic acid

2-Oh-saclofen

Benzeneethanesulfonic acid, beta-(aminomethyl)-4-chloro-beta-hydroxy-

beta-(Aminomethyl)-4-chloro-beta-hydroxybenzeneethanesulfonic acid

(RS)-3-AMINO-2-(4-CHLOROPHENYL)-2-HYDROXYPROPANESULPHONIC ACID

(RS)-3-AMINO-2-(4-CHLOROPHENYL)-2-HYDROXYPROPYL-SULFONIC ACID

(+/-)-3-AMINO-2-(4-CHLOROPHENYL)-2-HYDROXY-PROPANESULFONIC ACID

3-AMINO-2-(4-CHLOROPHENYL)-2-HYDROXYPROPANE-SULFONIC ACID

(+/-)-3-AMINO-2-(4-CHLOROPHENYL)-2-HYDROXYPROPYLSULFONIC ACID

2-HYDROXYSACLOFEN

2-Hydroxysaclofen solid

Benzeneethanesulfonic acid, β-(aminomethyl)-4-chloro-β-hydroxy-

2-Hydroxysaclofen >=98% (TLC), solid

3-amino-2-(4-chlorophenyl)-2-hydroxypropane-1-sulfonicaci

2-HYDROXYSACLOFEN ISO 9001：2015 REACH

2 Hydroxysaclofen,2Hydroxysaclofen

Benzeneethanesulfonic acid, b-(aminomethyl)-4-chloro-b-hydroxy-

117354-64-0

C9H12CINO4S

Modified Amino Acids

Biochemicals and Reagents

BioChemical

A - H

Amino Acids and Peptides

GABA/Glycine receptor