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2-HYDROXYSACLOFEN

Product Name
2-HYDROXYSACLOFEN
CAS No.
117354-64-0
Chemical Name
2-HYDROXYSACLOFEN
Synonyms
2-Oh-saclofen;HYDROXYSACLOFEN;2-HYDROXYSACLOFEN;2-HYDROXYSACLOFEN, >99%;2-Hydroxysaclofen solid;2 Hydroxysaclofen,2Hydroxysaclofen;2-Hydroxysaclofen >=98% (TLC), solid;2-HYDROXYSACLOFEN ISO 9001：2015 REACH;2-HYDROXYSACLOFEN GABA(B) RECEPTOR ANTA;3-amino-2-(4-chlorophenyl)-2-hydroxy-*propanesulf
CBNumber
CB0299578
Molecular Formula
C9H12ClNO4S
Formula Weight
265.71
MOL File
117354-64-0.mol
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2-HYDROXYSACLOFEN Property

Melting point:
267-269 °C
RTECS 
DA0359200
storage temp. 
2-8°C
solubility 
H2O: 1 mg/mL
form 
solid
color 
white
Water Solubility 
Soluble in water at 1mg/ml. Also soluble in DMSO, 0.1M HCl and methanol
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Safety

Hazard Codes 
C
Risk Statements 
34
Safety Statements 
26-27-36/37/39-45
RIDADR 
UN 1759 8/PG 3
WGK Germany 
3
HazardClass 
8
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A6566
Product name
2-Hydroxysaclofen
Purity
≥98% (TLC), solid
Packaging
2.5mg
Price
$138.7
Updated
2025/07/31
Tocris
Product number
0245
Product name
2-Hydroxysaclofen
Packaging
10
Price
$214
Updated
2021/12/16
Tocris
Product number
0245
Product name
2-Hydroxysaclofen
Packaging
50
Price
$878
Updated
2021/12/16
TRC
Product number
H953138
Product name
2-Hydroxysaclofen
Packaging
5mg
Price
$395
Updated
2021/12/16
Usbiological
Product number
254361
Product name
2-Hydroxysaclofen
Packaging
10mg
Price
$495
Updated
2021/12/16
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2-HYDROXYSACLOFEN Chemical Properties,Usage,Production

Uses

2-Hydroxysaclofen is a GABA-B receptor antagonist in the ventral tegmental area and may play a role in the mechanisms of cocaine usage. Affects specific acute nicotine responses in mice, abolishing hypolocomotion and increasing antinociception.

Definition

ChEBI: 3-amino-2-(4-chlorophenyl)-2-hydroxy-1-propanesulfonic acid is an organochlorine compound.

Biological Activity

Selective antagonist at GABA B receptors.

in vivo

2-Hydroxysaclofen (0.25-1 mg/kg; IP; single dosage) abolishes nicotine hypolocomotor effects and increases the antinociceptive effects of nicotine[1].
2-Hydroxysaclofen (0.3-3 mg/kg; IP; single dosage) reduces the effects of Baclofen (a GABA receptor agonist) on d-amphetamine-induced discriminative cue[2].
2-Hydroxysaclofen (0-100 μg/2 μl; ICV; single dosage) produces a rapid elevation in the serum LH concentration in the estrogen-primed ovariectomized rat[3].

Animal Model:Male Swiss Webster mice (22-24 g; treated with 3 mg/kg nicotine)[1]
Dosage:0.25, 0.5 and 1 mg/kg
Administration:IP; single dosage; after 10 or 45 min of nicotine administration
Result:Abolished nicotine hypolocomotor effects at 1 mg/kg, and increased the antinociceptive effects of nicotine at 1 mg/kg.
Animal Model:Male Wistar rats[2]
Dosage:0.3, 1 and 3 mg/kg
Administration:IP; single dosage
Result:Reduced the effects of Baclofen on d-amphetamine-induced discriminative cue.
Animal Model:Female Wistar rats (8 weeks)[3]
Dosage:0, 20, 50 or 100 μg/2 μL
Administration:ICV; single dosage
Result:Produced a rapid elevation in the serum LH concentration in the estrogen-primed ovariectomized rat with a dose-dependent manner, and the peak LH values were observed 10 min after the injection.
The effect was dose-dependent, as 0 or 20 μg of the antagonist was ineffective while a pronounced effect was observed after the injection of 50 or 100 μg.

storage

Store at RT

2-HYDROXYSACLOFEN Preparation Products And Raw materials

Raw materials

Preparation Products

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2-HYDROXYSACLOFEN Suppliers

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View Lastest Price from 2-HYDROXYSACLOFEN manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
2-Hydroxysaclofen 117354-64-0
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99.0%+
Supply Ability
100 tons
Release date
2019-12-31

117354-64-0, 2-HYDROXYSACLOFENRelated Search:

5-hydroxysaclofen 1-AMINO-2-METHYL-PROPAN-2-OL HCL P-CHLORO-BETA-METHYL-PHENETHYLAMINE HYDROCHLORIDE 2-HYDROXYSACLOFEN 1-AMINO-2-(4-CHLORO-PHENYL)-PROPAN-2-OL SACLOFEN 1-AMINO-2-PHENYL-PROPAN-2-OL 2-Amino-1-(4-chlorophenyl)ethan-1-ol Ammonium 2-hydroxyethanesulphonate

  • HYDROXYSACLOFEN
  • 3-amino-2-(4-chlorophenyl)-2-hydroxy-*propanesulf
  • 2-HYDROXYSACLOFEN GABA(B) RECEPTOR ANTA
  • 3-AMINO-2-(4-CHLOROPHENYL)-2-HYDROXY-PRO PANESULFON
  • 2-HYDROXYSACLOFEN, >99%
  • 3-Amino-2-(4-chlorophenyl)-2-hydroxypropane-1-sulfonic acid
  • 3-Amino-2-hydroxy-2-(4-chlorophenyl)propane-1-sulfonic acid
  • 2-Oh-saclofen
  • Benzeneethanesulfonic acid, beta-(aminomethyl)-4-chloro-beta-hydroxy-
  • beta-(Aminomethyl)-4-chloro-beta-hydroxybenzeneethanesulfonic acid
  • (RS)-3-AMINO-2-(4-CHLOROPHENYL)-2-HYDROXYPROPANESULPHONIC ACID
  • (RS)-3-AMINO-2-(4-CHLOROPHENYL)-2-HYDROXYPROPYL-SULFONIC ACID
  • (+/-)-3-AMINO-2-(4-CHLOROPHENYL)-2-HYDROXY-PROPANESULFONIC ACID
  • 3-AMINO-2-(4-CHLOROPHENYL)-2-HYDROXYPROPANE-SULFONIC ACID
  • (+/-)-3-AMINO-2-(4-CHLOROPHENYL)-2-HYDROXYPROPYLSULFONIC ACID
  • 2-HYDROXYSACLOFEN
  • 2-Hydroxysaclofen solid
  • Benzeneethanesulfonic acid, β-(aminomethyl)-4-chloro-β-hydroxy-
  • 2-Hydroxysaclofen >=98% (TLC), solid
  • 3-amino-2-(4-chlorophenyl)-2-hydroxypropane-1-sulfonicaci
  • 2-HYDROXYSACLOFEN ISO 9001：2015 REACH
  • 2 Hydroxysaclofen,2Hydroxysaclofen
  • Benzeneethanesulfonic acid, b-(aminomethyl)-4-chloro-b-hydroxy-
  • 117354-64-0
  • C9H12CINO4S
  • Modified Amino Acids
  • Biochemicals and Reagents
  • BioChemical
  • A - H
  • Amino Acids and Peptides
  • GABA/Glycine receptor