ChemicalBook > CAS DataBase List > LDN-212320

LDN-212320

Product Name: LDN-212320
CAS No.: 894002-50-7
Chemical Name: LDN-212320
Synonyms: LDN-212320;OSU-0212320;LDN-0212320;LDN/OSU-0212320;LDN-0212320 Maleate;LDN 0212320 (LDN212320;LDN-212320, 10 mM in DMSO;LDN/OSU-0212320;LDN-0212320;OSU-0212320;3-((2-methylbenzyl)thio)-6-(pyridin-2-yl)pyridazine;(3-[(2-methylbenzyl)sulfenyl]-6-(pyridine-2-yl)pyridazine)
CBNumber: CB03034769
Molecular Formula: C17H15N3S
Formula Weight: 293.39
MOL File: 894002-50-7.mol

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LDN-212320 Property

storage temp.: Store at -20°C
solubility: DMSO : 50 mg/mL (170.42 mM; Need ultrasonic)
form: Powder
color: White to gray
InChI: InChI=1S/C17H15N3S/c1-13-6-2-3-7-14(13)12-21-17-10-9-16(19-20-17)15-8-4-5-11-18-15/h2-11H,12H2,1H3
InChIKey: DUUQLWDHNYFUPP-UHFFFAOYSA-N
SMILES: C1(SCC2=CC=CC=C2C)=NN=C(C2=NC=CC=C2)C=C1

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21650
Product name: LDN-0212320
Packaging: 5mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 21650
Product name: LDN-0212320
Packaging: 10mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 21650
Product name: LDN-0212320
Packaging: 25mg
Price: $239
Updated: 2024/03/01

Cayman Chemical

Product number: 21650
Product name: LDN-0212320
Packaging: 50mg
Price: $419
Updated: 2024/03/01

Tocris

Product number: 5082
Product name: LDN212320
Purity: ≥98%(HPLC)
Packaging: 50
Price: $609
Updated: 2021/12/16

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LDN-212320 Chemical Properties,Usage,Production

Uses

LDN 212320 is a small molecule activator of glutamate transporter EAAT2 translation, which provides neuroprotection and shows potential for the therapeutic treatment of neurodegenerative diseases.

in vivo

LDN-212320 (10 or 20 mg/kg, i.p) significantly attenuates formalin-evoked nociceptive behavior^[1].
LDN-212320 (10 or 20 mg/kg, i.p) significantly reverses formalin-induced impaired hippocampal-dependent behavior. In addition, LDN-212320 (10 or 20 mg/kg, i.p) increases GLT-1 expressions in the hippocampus and ACC^[1].
LDN-212320 (20 mg/kg, i.p) significantly reduced formalin induced-ERK phosphorylation, a marker of nociception, in the hippocampus and ACC^[1].

Animal Model:	Mice^[1].
Dosage:	10 or 20 mg/kg.
Administration:	IP 24 h before the injection of formalin.
Result:	Significantly attenuated licking and biting behavior during both phases 1 and 2 in a dose-dependent manner compared to formalin-injected mice. Significantly (P < 0.01 or P < 0.001) reduced the licking and biting behavior. Significantly increased preference for the displaced object (F_{3, 13} = 28.03, P < 0.01) compared to formalin-injected mice. Significantly (P < 0.001) increased interaction time with the displaced object compared to formalin-injected mice.

IC 50

EAAT2

LDN-212320 Preparation Products And Raw materials

Raw materials

Preparation Products

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894002-50-7, LDN-212320Related Search:

LDN-214117 LDN-193189 LDN212854 LDN-193189 HCl

LDN-212320

LDN-0212320

3-[[(2-Methylphenyl)methyl]thio]-6-(2-pyridinyl)-pyridazine

(3-[(2-methylbenzyl)sulfenyl]-6-(pyridine-2-yl)pyridazine)

LDN/OSU-0212320

LDN/OSU-0212320;LDN-0212320;OSU-0212320

OSU-0212320

3-((2-methylbenzyl)thio)-6-(pyridin-2-yl)pyridazine

Pyridazine, 3-[[(2-methylphenyl)methyl]thio]-6-(2-pyridinyl)-

LDN-0212320 Maleate

LDN0212320,LDN-212320,Glutamate transporter 1,OSU 0212320,inhibit,EAAT2,Inhibitor,OSU0212320,LDN212320,LDN 212320,GLT-1,LDN 0212320,Excitatory amino acid transporter 2

LDN-212320, 10 mM in DMSO

LDN 0212320 (LDN212320

894002-50-7