LDN-214117

Product Name: LDN-214117
CAS No.: 1627503-67-6
Chemical Name: LDN-214117
Synonyms: CS-1539;LDN-214117;LDN-214117 ，S7627;LDN-214117;LDN214117;LDN-214117 USP/EP/BP;LDN-214117, 10 mM in DMSO;1-(4-(6-methyl-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl)phenyl)piperazine;1-[4-[6-Methyl-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenyl]piperazine;Piperazine, 1-[4-[6-methyl-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenyl]-;LDN214117,LDN-214117,ALK2,BMP4,BMP2,Transforming growth factor beta receptors,LDN 214117,BMP6,TGF-β Receptor,diffuse intrinsic pontine glioma(DIPG),oral,ALK3,fibrodysplasia ossificans progressiva (FOP),ALK5,type I receptor kinases,ALK1,bone morphogenetic proteins (BMPs)
CBNumber: CB92729368
Molecular Formula: C25H29N3O3
Formula Weight: 419.52
MOL File: 1627503-67-6.mol

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LDN-214117 Property

Boiling point:: 567.9±50.0 °C(Predicted)
Density: 1.134±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMF:30.0(Max Conc. mg/mL);71.51(Max Conc. mM)
DMF:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.19(Max Conc. mM)
DMSO:42.67(Max Conc. mg/mL);101.7(Max Conc. mM)
Ethanol:54.0(Max Conc. mg/mL);128.72(Max Conc. mM)
pka: 8.86±0.10(Predicted)
form: Powder
color: Light yellow to yellow
InChI: 1S/C25H29N3O3/c1-17-22(19-14-23(29-2)25(31-4)24(15-19)30-3)13-20(16-27-17)18-5-7-21(8-6-18)28-11-9-26-10-12-28/h5-8,13-16,26H,9-12H2,1-4H3
InChIKey: BHUXVRVMMYAXKN-UHFFFAOYSA-N
SMILES: CC(C(C1=CC(OC)=C(OC)C(OC)=C1)=C2)=NC=C2C(C=C3)=CC=C3N4CCNCC4

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
WGK Germany: WGK 3
Storage Class: 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications: Acute Tox. 3 Oral

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1119
Product name: LDN-214117
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $196
Updated: 2026/03/19

Sigma-Aldrich

Product number: SML1119
Product name: LDN-214117
Purity: ≥98% (HPLC)
Packaging: 25 mg
Price: $655
Updated: 2026/03/19

Cayman Chemical

Product number: 18006
Product name: LDN-214117
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 18006
Product name: LDN-214117
Purity: ≥98%
Packaging: 5mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 18006
Product name: LDN-214117
Purity: ≥98%
Packaging: 10mg
Price: $184
Updated: 2024/03/01

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LDN-214117 Chemical Properties,Usage,Production

Uses

LDN 214117 is a highly selective ALK2 inhibitor.

Biological Activity

LDN-214117 is a selective inhibitor of the bone morphogenetic protein (BMP) type I receptor kinases with high selectivity for BMP versus TGF-β signaling, and low cytotoxicity. LDN-214117 inhibited ALK2 most, with a biochemical IC50 of 24 nM, followed by TNIK, RIPK2, and ABL1. LDN-214117 has a cell-based IC50 for BMP6 of approximately 100 nM and 164-fold selectivity for BMP6 versus TGF-β1. Fibrodysplasia ossificans progressiva (FOP) is a debilitating and progressive heterotopic ossification disease caused by activating mutations of ACVR1 encoding the BMP type I receptor kinase ALK2. LDN-214117 had nearly identical binding affinity for wild-type ALK2 and each of the FOP-causing mutants tested.

in vivo

LDN-214117 (p.o., 25 mg/kg, daily, for 14 days) has well-tolerated in mice^[3].

Animal Model:	NOD.SCID mice^[3]
Dosage:	25 mg/kg
Administration:	p.o., daily, for 14 days
Result:	Showed good-tolerated in mice.

LDN-214117 Preparation Products And Raw materials

Raw materials

Preparation Products

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LDN-214117 Suppliers

China 79 United Kingdom 1 United States 14 Global 94

Shanghai Boyle Chemical Co., Ltd.

Tel
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Email: sales@boylechem.com
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Chembest Research Laboratories Limited

Tel: 021-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
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Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
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MedChemexpress LLC

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Email: sales@medchemexpress.cn
Country: United States
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ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185 18149758185
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Bide Pharmatech Ltd.

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Email: product02@bidepharm.com
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Shanghai Qinghang Chemical Co. Ltd.

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LETOPHARM LIMITED

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Shanghai Lollane Biological Technology Co.,Ltd.

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Fax: +86-21-52996696
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YouCoChem (Beijing) Chemical Technology Co., Ltd.

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Email: youcochem@163.com
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1627503-67-6, LDN-214117Related Search:

LDN-212320 LDN-193189 HCl LDN-193189 LDN212854

1-[4-[6-Methyl-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenyl]piperazine

LDN-214117;LDN214117

CS-1539

LDN-214117

1-(4-(6-methyl-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl)phenyl)piperazine

Piperazine, 1-[4-[6-methyl-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenyl]-

LDN-214117 USP/EP/BP

LDN214117,LDN-214117,ALK2,BMP4,BMP2,Transforming growth factor beta receptors,LDN 214117,BMP6,TGF-β Receptor,diffuse intrinsic pontine glioma(DIPG),oral,ALK3,fibrodysplasia ossificans progressiva (FOP),ALK5,type I receptor kinases,ALK1,bone morphogenetic proteins (BMPs)

LDN-214117, 10 mM in DMSO

LDN-214117 ，S7627

1627503-67-6

Inhibitors