ChemicalBook > CAS DataBase List > BC2059

BC2059

Product Name
BC2059
CAS No.
1227637-23-1
Chemical Name
BC2059
Synonyms
BC2059;Tegavivint;Tegoprazan D6;BC-2059 Te atrabetan;Tegatrabetan (BC2059);BC-2059;BC2059;TEGAVIVINT;TEGATRABETAN;BC-2059;TEGAVIVINT;Tegatrabetan,inhibit,Inhibitor,β-catenin,BC-2059,Beta catenin,BC 2059;rel-2,7-Bis(((3R,5S)-3,5-dimethylpiperidin-1-yl)sulfonyl)anthracene-9,10-dione dioxime;9,10-Anthracenedione, 2,7-bis[[(3R,5S)-3,5-dimethyl-1-piperidinyl]sulfonyl]-, 9,10-dioxime, rel-
CBNumber
CB03038499
Molecular Formula
C28H36N4O6S2
Formula Weight
588.74
MOL File
1227637-23-1.mol
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BC2059 Property

Boiling point:
757.6±70.0 °C(Predicted)
Density 
1.46±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
DMSO: 125 mg/mL (212.32 mM)
pka
10.07±0.20(Predicted)
form 
Solid
color 
White to light yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0039507
Product name
Tegatrabetan
Purity
98.19%
Packaging
5mg
Price
$90
Updated
2021/12/16
ChemScene
Product number
CS-0039507
Product name
Tegatrabetan
Purity
98.19%
Packaging
10mg
Price
$150
Updated
2021/12/16
ChemScene
Product number
CS-0039507
Product name
Tegatrabetan
Purity
98.19%
Packaging
50mg
Price
$430
Updated
2021/12/16
DC Chemicals
Product number
DC20756
Product name
Tegatrabetan
Purity
>98%
Packaging
100mg
Price
$650
Updated
2021/12/16
DC Chemicals
Product number
DC20756
Product name
Tegatrabetan
Purity
>98%
Packaging
1g
Price
$2500
Updated
2021/12/16
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BC2059 Chemical Properties,Usage,Production

Biological Activity

Tegatrabetan (BC2059) is a beta-Catenin antagonist. It disrupts β-catenin binding to scaffold protein transducin β-like 1 (TBL1) and proteasomal degradation and reduces β-catenin nuclear levels.

in vivo

Tegatrabetan (BC2059; 1.0 or 5.0 mg/kg/day; intravenously) significantly improves the median survival of the mice from approximately 17.5 to 39 days. Treatment with Tegatrabetan (10 mg/kg/day; intravenously) alone further improves the median survival to 51.5 days.

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Animal Model: NOD/SCID mice bearing OCI-AML3 xenografts
Dosage: 1 mg/kg; 5 mg/kg; 10 mg/kg
Administration: Intravenously; 1 mg/kg daily 4 days per week or 5 mg/kg or 10 mg/kg of BC2059 twice per week (Tuesday and Thursday) for 3 weeks.
Result: Treatment significantly improved survival of NOD/SCID mice bearing OCI-AML3 xenografts.

target

TargetValue
β-catenin
()

BC2059 Preparation Products And Raw materials

Raw materials

Preparation Products

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BC2059 Suppliers

China 23 India 1 United States 5 Global 29
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38631
Advantage
58
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58

1227637-23-1, BC2059Related Search:


  • BC2059
  • BC-2059;BC2059;TEGAVIVINT
  • Tegavivint
  • TEGATRABETAN;BC-2059;TEGAVIVINT
  • 9,10-Anthracenedione, 2,7-bis[[(3R,5S)-3,5-dimethyl-1-piperidinyl]sulfonyl]-, 9,10-dioxime, rel-
  • rel-2,7-Bis(((3R,5S)-3,5-dimethylpiperidin-1-yl)sulfonyl)anthracene-9,10-dione dioxime
  • Tegatrabetan (BC2059)
  • Tegatrabetan,inhibit,Inhibitor,β-catenin,BC-2059,Beta catenin,BC 2059
  • Tegoprazan D6
  • BC-2059 Te atrabetan
  • 1227637-23-1