JP 1302 2HCl
- Product Name
- JP 1302 2HCl
- CAS No.
- 1259314-65-2
- Chemical Name
- JP 1302 2HCl
- Synonyms
- JP-1302 HCl;JP 1302 2HCl;JP-1302 (hydrochloride);JP1302 dihydrochloride, 10 mM in DMSO;JP1302 dihydrochloride, alpha2C antagonist;N-(4-(4-Methylpiperazin-1-yl)phenyl)acridin-9-amine dihydrochloride;Inhibitor,JP 1302,JP-1302,JP1302 dihydrochloride,inhibit,JP1302,Beta Receptor,Adrenergic Receptor,JP-1302 dihydrochloride
- CBNumber
- CB03038505
- Molecular Formula
- C24H25ClN4
- Formula Weight
- 404.94
- MOL File
- 1259314-65-2.mol
JP 1302 2HCl Property
- storage temp.
- Store at -20°C
- solubility
- Soluble to 100 mM in water and to 5 mM in DMSO
- form
- Powder
- color
- Brown to reddish brown
- Water Solubility
- Soluble to 100 mM in water
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- J212010
- Product name
- JP1302Dihydrochloride
- Packaging
- 10mg
- Price
- $160
- Updated
- 2021/12/16
- Product number
- CS-0025304
- Product name
- JP1302dihydrochloride
- Purity
- 99.83%
- Packaging
- 5mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- CS-0025304
- Product name
- JP1302dihydrochloride
- Purity
- 99.83%
- Packaging
- 10mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- CS-0025304
- Product name
- JP1302dihydrochloride
- Purity
- 99.83%
- Packaging
- 50mg
- Price
- $480
- Updated
- 2021/12/16
- Product number
- CS-0025304
- Product name
- JP1302dihydrochloride
- Purity
- 99.83%
- Packaging
- 100mg
- Price
- $750
- Updated
- 2021/12/16
JP 1302 2HCl Chemical Properties,Usage,Production
Uses
JP 1302 Dihydrochloride is an α2-adrenoceptor blocker and can be used for the treatment or prevention of nephropathy.
in vivo
JP1302 (1-10 μmol/kg) decreases immobility time in the FST to a level similar to that seen with 10-30 μmol/kg of the antidepressant Desipramine (HY-B1272A)[1].
JP1302 (5 μmol/kg, once) is capable of complete reversal of the impairment in PPI induced in Sprague-Dawley rats by the psychotomimetic NMDA receptor antagonist, phencyclidine and similar results are found in Wistar rats[1].
JP1302 (3 mg/kg, IV, once) significantly ameliorates renal dysfunction[3].
| Animal Model: | Male Sprague Dawley rats (8 weeks old)[3] |
| Dosage: | 3 mg/kg |
| Administration: | IV, pre-treatment: administered 5 min before the induction of ischemia, post-treatment: injected 45 min after the initiation of reperfusion |
| Result: | Significantly ameliorated renal dysfunction in the rats at 24 h after reperfusion. post-ischemic administration of JP-1302 significantly ameliorated renal dysfunction, histological damage and reduced apoptotic cells and pro-inflammatory cytokine mRNA expression. |
IC 50
human α2C-adrenoceptor: 28±2 nM (Ki); human α2B-adrenoceptor: 1470±130 nM (Ki); human α2A-adrenoceptor: 3150±50 nM (Ki); rodent α2D-adrenoceptor: 1700±200 nM (Ki)
storage
Store at -20°C
JP 1302 2HCl Preparation Products And Raw materials
Raw materials
Preparation Products
JP 1302 2HCl Suppliers
- Tel
- --
- Fax
- --
- customerservice@tocris.co.uk
- Country
- United Kingdom
- ProdList
- 5726
- Advantage
- 77
View Lastest Price from JP 1302 2HCl manufacturers
- Product
- JP 1302 2HCl 1259314-65-2
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- Customise
- Release date
- 2025-09-18