ChemicalBook > CAS DataBase List > CC-115

CC-115

Product Name
CC-115
CAS No.
1228013-15-7
Chemical Name
CC-115
Synonyms
CC-115;CS-2038;CC-115, >95%;CC115;CC 115;CC-115(free base);DNA-dependent protein kinase,inhibit,CC115,CC-115,DNA-PK,mTOR,Inhibitor,Mammalian target of Rapamycin;1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-5-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one;1-Ethyl-7-(2-methyl-6-(4h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one;Pyrazino[2,3-b]pyrazin-2(1H)-one, 1-ethyl-3,4-dihydro-7-[2-methyl-6-(1H-1,2,4-triazol-5-yl)-3-pyridinyl]-
CBNumber
CB03041392
Molecular Formula
C16H16N8O
Formula Weight
336.35
MOL File
1228013-15-7.mol
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CC-115 Property

Boiling point:
587.3±60.0 °C(Predicted)
Density 
1.56±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
≥50 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
form 
solid
pka
5.94±0.20(Predicted)
color 
Pink to red
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
19420
Product name
CC-115
Purity
≥95%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
19420
Product name
CC-115
Purity
≥95%
Packaging
5mg
Price
$139
Updated
2024/03/01
Cayman Chemical
Product number
19420
Product name
CC-115
Purity
≥95%
Packaging
10mg
Price
$243
Updated
2024/03/01
Cayman Chemical
Product number
19420
Product name
CC-115
Purity
≥95%
Packaging
25mg
Price
$533
Updated
2024/03/01
ChemScene
Product number
CS-4561
Product name
CC-115
Purity
96.64%
Packaging
10mg
Price
$150
Updated
2021/12/16
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CC-115 Chemical Properties,Usage,Production

Biological Activity

cc-115 is a inhibitor of mtor/dna-pk.the mammalian target of rapamycin (mtor) kinase is a key mediator of the phosphoinositide 3-kinase /protein kinase b (akt pathway). the dna-dependent protein kinase (dna-pk) is a critical component of the dna repair machinery governings the response to dna damage, which serves to maintain genome integrity.

in vitro

previous study found that the proliferation induced by cd40(+) interleukin-21 stimulation could be completely blocked by cc-115, and cd40-mediated resistance to fludarabine and venetoclax could also be reverted by cc-115. moreover, bcr-mediated signaling was blocked by cc-115 and in cll samples from patients with acquired resistance to idelalisib treatment [1].

in vivo

preclinical studies showed that cc-115 had good in vivo pk profiles across multiple species with 53%, 76%, and around100% oral bioavailability in mouse, rat, and dog, respectively [2].

target

TargetValue
DNA-PK
(Cell-free assay)
0.013 μM
mTOR
(Cell-free assay)
0.021 μM
PI3Kα
(Cell-free assay)
0.852 μM

IC 50

21/ 13 nm for mtor/dna-pk

References

[1] thijssen r,et al. dual tork/dna-pk inhibition blocks critical signaling pathways in chronic lymphocytic leukemia. blood.2016 jul 28;128(4):574-83.
[2] mortensen ds, et al. optimization of a series of triazole containing mammalian target of rapamycin (mtor) kinase inhibitors and the discovery of cc-115. j med chem. 2015 jul 23;58(14):5599-5608.

CC-115 Preparation Products And Raw materials

Raw materials

Preparation Products

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CC-115 Suppliers

Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38631
Advantage
58
ApexBio Technology
Tel
--
Fax
--
Email
sales@apexbt.com
Country
United States
ProdList
6251
Advantage
58
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
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View Lastest Price from CC-115 manufacturers

Career Henan Chemical Co
Product
CC-115 1228013-15-7
Price
US $1.00/ASSAYS
Min. Order
1ASSAYS
Purity
95%~99%
Supply Ability
per week:100kg
Release date
2019-09-05

1228013-15-7, CC-115Related Search:


  • CS-2038
  • CC115;CC 115
  • CC-115, >95%
  • CC-115(free base)
  • 1-Ethyl-7-(2-methyl-6-(4h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one
  • CC-115
  • 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-5-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one
  • Pyrazino[2,3-b]pyrazin-2(1H)-one, 1-ethyl-3,4-dihydro-7-[2-methyl-6-(1H-1,2,4-triazol-5-yl)-3-pyridinyl]-
  • DNA-dependent protein kinase,inhibit,CC115,CC-115,DNA-PK,mTOR,Inhibitor,Mammalian target of Rapamycin
  • 1228013-15-7