Givinostat (hydrochloride)
- Product Name
- Givinostat (hydrochloride)
- CAS No.
- 199657-29-9
- Chemical Name
- Givinostat (hydrochloride)
- Synonyms
- ITF2357 HCl;Givinostat Hcl;ITF-2357 hydrochloride;Gavinostat hydrochloride;Givinostat (ITF2357) HCl;Givinostat (hydrochloride);Givinostat HCl. gavinostat;Givinostat (ITF2357) hydrochloride;GAVINOSTAT HYDROCHLORIDE;ITF-2357 HYDROCHLORIDE;inhibit,Givinostat hydrochloride,Histone deacetylases,Givinostat,Inhibitor,HDAC
- CBNumber
- CB03041408
- Molecular Formula
- C24H28ClN3O4
- Formula Weight
- 457.96
- MOL File
- 199657-29-9.mol
Givinostat (hydrochloride) Property
- storage temp.
- Store at -20°C
- solubility
- DMSO:45.8(Max Conc. mg/mL);100.01(Max Conc. mM)
N-Bromosuccinimide Price
- Product number
- 6249
- Product name
- Givinostathydrochloride
- Purity
- ≥98%(HPLC)
- Packaging
- 5
- Price
- $98
- Updated
- 2021/12/16
- Product number
- 6249
- Product name
- Givinostathydrochloride
- Purity
- ≥98%(HPLC)
- Packaging
- 25
- Price
- $381
- Updated
- 2021/12/16
- Product number
- CD31002770
- Product name
- Givinostathydrochloride
- Purity
- 98+%
- Packaging
- 50mg
- Price
- $251
- Updated
- 2021/12/16
- Product number
- CD31002770
- Product name
- Givinostathydrochloride
- Purity
- 98+%
- Packaging
- 100mg
- Price
- $376
- Updated
- 2021/12/16
Givinostat (hydrochloride) Chemical Properties,Usage,Production
Biological Activity
Givinostat (ITF-2357) hydrochloride is an HDAC inhibitor, inhibits HDAC1 and HDAC3 with IC50 of 198 nM and 157 nM, respectively.
in vitro
Givinostat (hydrochloride) suppresses total LPS-induced IL-1β production robustly compared with the reduction by ITF3056. At 25, 50, and 100 nM, Givinostat reduces IL-1β secretion more than 70%. Givinostat suppresses the production of IL-6 in PBMCs stimulated with TLR agonists as well as the combination of IL-12 plus IL-18.
in vivo
Givinostat (ITF2357) at 10 mg/kg is used as a positive control and reduces serum TNFα by 60%. Pretreatment of Givinostat (ITF-2357) starting at 0.1 mg/kg significantly reduces the circulating TNFα by nearly 90%. To achieve a significant increase in serum IL-1β production, a higher dose of LPS is injected (10 mg/kg), and blood is collected after 4 h.
target
| hHDAC3 157 nM (IC 50 ) | hHDAC1 198 nM (IC 50 ) | hHDAC11 292 nM (IC 50 ) | hHDAC6 315 nM ( IC 50 ) | hHDAC2 325 nM (IC 50 ) | hHDAC10 340 nM (IC < sub> 50 ) | hHDAC7 524 nM (IC 50 ) | hHDAC5 532 nM (IC 50 ) | hHDAC9 541 nM (IC 50 ) | hHDAC8 854 nM (IC 50 < /sub> ) | hHDAC4 1059 nM (IC 50 ) | HD1-B 7.5 nM (IC 50 ) | HD1-A 16 nM (IC 50 ) | HD2 10 nM (IC 50 ) |
storage
Store at -20°C
Givinostat (hydrochloride) Preparation Products And Raw materials
Raw materials
Preparation Products
Givinostat (hydrochloride) Suppliers
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- 021-58955995
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