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Givinostat (hydrochloride)

Product Name
Givinostat (hydrochloride)
CAS No.
199657-29-9
Chemical Name
Givinostat (hydrochloride)
Synonyms
ITF2357 HCl;Givinostat Hcl;ITF-2357 hydrochloride;Gavinostat hydrochloride;Givinostat (ITF2357) HCl;Givinostat (hydrochloride);Givinostat HCl. gavinostat;Givinostat (ITF2357) hydrochloride;GAVINOSTAT HYDROCHLORIDE;ITF-2357 HYDROCHLORIDE;inhibit,Givinostat hydrochloride,Histone deacetylases,Givinostat,Inhibitor,HDAC
CBNumber
CB03041408
Molecular Formula
C24H28ClN3O4
Formula Weight
457.96
MOL File
199657-29-9.mol
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Givinostat (hydrochloride) Property

storage temp. 
Store at -20°C
solubility 
DMSO:45.8(Max Conc. mg/mL);100.01(Max Conc. mM)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
6249
Product name
Givinostathydrochloride
Purity
≥98%(HPLC)
Packaging
5
Price
$98
Updated
2021/12/16
Tocris
Product number
6249
Product name
Givinostathydrochloride
Purity
≥98%(HPLC)
Packaging
25
Price
$381
Updated
2021/12/16
Crysdot
Product number
CD31002770
Product name
Givinostathydrochloride
Purity
98+%
Packaging
50mg
Price
$251
Updated
2021/12/16
Crysdot
Product number
CD31002770
Product name
Givinostathydrochloride
Purity
98+%
Packaging
100mg
Price
$376
Updated
2021/12/16
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Givinostat (hydrochloride) Chemical Properties,Usage,Production

Biological Activity

Givinostat (ITF-2357) hydrochloride is an HDAC inhibitor, inhibits HDAC1 and HDAC3 with IC50 of 198 nM and 157 nM, respectively.

in vitro

Givinostat (hydrochloride) suppresses total LPS-induced IL-1β production robustly compared with the reduction by ITF3056. At 25, 50, and 100 nM, Givinostat reduces IL-1β secretion more than 70%. Givinostat suppresses the production of IL-6 in PBMCs stimulated with TLR agonists as well as the combination of IL-12 plus IL-18.

in vivo

Givinostat (ITF2357) at 10 mg/kg is used as a positive control and reduces serum TNFα by 60%. Pretreatment of Givinostat (ITF-2357) starting at 0.1 mg/kg significantly reduces the circulating TNFα by nearly 90%. To achieve a significant increase in serum IL-1β production, a higher dose of LPS is injected (10 mg/kg), and blood is collected after 4 h.

target

hHDAC3

157 nM (IC 50 )

hHDAC1

198 nM (IC 50 )

hHDAC11

292 nM (IC 50 )

hHDAC6

315 nM ( IC 50 )

hHDAC2

325 nM (IC 50 )

hHDAC10

340 nM (IC < sub> 50 )

hHDAC7

524 nM (IC 50 )

hHDAC5

532 nM (IC 50 )

hHDAC9

541 nM (IC 50 )

hHDAC8

854 nM (IC 50 < /sub> )

hHDAC4

1059 nM (IC 50 )

HD1-B

7.5 nM (IC 50 )

HD1-A

16 nM (IC 50 )

HD2

10 nM (IC 50 )

storage

Store at -20°C

Givinostat (hydrochloride) Preparation Products And Raw materials

Raw materials

Preparation Products

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Givinostat (hydrochloride) Suppliers

MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
52924
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38631
Advantage
58
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58

199657-29-9, Givinostat (hydrochloride)Related Search:


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  • inhibit,Givinostat hydrochloride,Histone deacetylases,Givinostat,Inhibitor,HDAC
  • 199657-29-9