ChemicalBook > CAS DataBase List > 3-Trifluoromethyl-piperazine-1-carboxylic acid tert-butyl ester

3-Trifluoromethyl-piperazine-1-carboxylic acid tert-butyl ester

Product Name
3-Trifluoromethyl-piperazine-1-carboxylic acid tert-butyl ester
CAS No.
886779-69-7
Chemical Name
3-Trifluoromethyl-piperazine-1-carboxylic acid tert-butyl ester
Synonyms
1-Boc-3-(trifluoromethyl)piperazine;tert-butyl 3-(trifluoromethyl)piperazine-1-carboxylate;1-Piperazinecarboxylic acid, 3-(trifluoromethyl)-, 1,1-dimethylethyl ester
CBNumber
CB03048801
Molecular Formula
C10H17F3N2O2
Formula Weight
254.25
MOL File
886779-69-7.mol
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3-Trifluoromethyl-piperazine-1-carboxylic acid tert-butyl ester Property

Boiling point:
263.4±35.0 °C(Predicted)
Density 
1.189±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
5.95±0.40(Predicted)
Appearance
White to off-white Solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific
Product number
4565AJ
Product name
tert-Butyl3-(trifluoromethyl)piperazine-1-carboxylate
Packaging
1g
Price
$917
Updated
2021/12/16
J&W Pharmlab
Product number
65R0282
Product name
3-Trifluoromethyl-piperazine-1-carboxylicacidtert-butylester
Purity
96%
Packaging
5g
Price
$1998
Updated
2021/12/16
Ambeed
Product number
A564989
Product name
tert-Butyl3-(trifluoromethyl)piperazine-1-carboxylate
Purity
95%
Packaging
50mg
Price
$122
Updated
2021/12/16
J&W Pharmlab
Product number
65R0282
Product name
3-Trifluoromethyl-piperazine-1-carboxylicacidtert-butylester
Purity
96%
Packaging
50mg
Price
$131
Updated
2021/12/16
J&W Pharmlab
Product number
65R0282
Product name
3-Trifluoromethyl-piperazine-1-carboxylicacidtert-butylester
Purity
96%
Packaging
100mg
Price
$162
Updated
2021/12/16
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3-Trifluoromethyl-piperazine-1-carboxylic acid tert-butyl ester Chemical Properties,Usage,Production

Synthesis

24424-99-5

131922-05-9

886779-69-7

To a solution of 2-(trifluoromethyl)piperazine (135 mg, 0.876 mmol) in dichloromethane (6 mL) was added di-tert-butyl dicarbonate (0.224 mL, 0.963 mmol) and the reaction mixture was stirred for 3 hours at room temperature. After completion of the reaction, the mixture was concentrated and the residue was purified by silica gel column chromatography (eluent: 0-100% hexane solution of ethyl acetate) to afford 1-Boc-3-trifluoromethylpiperazine (200 mg, 0.787 mmol, 90% yield) as a light yellow solid. Mass spectrometry (ES+) analysis: the theoretical value of C10H17F3N2O2 was 254 and the measured value was 155 [M+H]+ - Boc group.

References

[1] Patent: WO2018/136887, 2018, A1. Location in patent: Page/Page column 122
[2] Patent: WO2014/175621, 2014, A1. Location in patent: Paragraph 662; 663; 664

3-Trifluoromethyl-piperazine-1-carboxylic acid tert-butyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Trifluoromethyl-piperazine-1-carboxylic acid tert-butyl ester Suppliers

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