tert-butyl 3-carbaMoylazetidine-1-carboxylat
- Product Name
- tert-butyl 3-carbaMoylazetidine-1-carboxylat
- CAS No.
- 486415-29-6
- Chemical Name
- tert-butyl 3-carbaMoylazetidine-1-carboxylat
- Synonyms
- 1-Boc-azetidine-3-carboxamide;N-Boc-azetidine-3-carboxamide;1-N-Boc-azetidine-3-carboxamide;tert-butyl 3-carbaMoylazetidine-1-carboxylat;3-Carbamoyl-azetidine-1-carboxylic acid tert-butyl ester;1-Azetidinecarboxylic acid, 3-(aminocarbonyl)-, 1,1-dimethylethyl ester
- CBNumber
- CB72616725
- Molecular Formula
- C9H16N2O3
- Formula Weight
- 200.23
- MOL File
- 486415-29-6.mol
tert-butyl 3-carbaMoylazetidine-1-carboxylat Property
- Boiling point:
- 355.9±31.0 °C(Predicted)
- Density
- 1.194±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 16.06±0.20(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- B630295
- Product name
- N-Boc-azetidine-3-carboxamide
- Packaging
- 25mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 180317
- Product name
- tert-Butyl 3-(aminocarbonyl)azetidine-1-carboxylate
- Packaging
- 1g
- Price
- $500
- Updated
- 2021/12/16
- Product number
- CHM0096959
- Product name
- TERT-BUTYL 3-CARBAMOYLAZETIDINE-1-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $501.52
- Updated
- 2021/12/16
- Product number
- 180317
- Product name
- tert-Butyl 3-(aminocarbonyl)azetidine-1-carboxylate
- Packaging
- 500mg
- Price
- $400
- Updated
- 2021/12/16
- Product number
- P37902
- Product name
- 1-Boc-azetidine-3-carboxamide
- Purity
- 95%
- Packaging
- 1G
- Price
- $415
- Updated
- 2021/12/16
tert-butyl 3-carbaMoylazetidine-1-carboxylat Chemical Properties,Usage,Production
Synthesis
142253-55-2
486415-29-6
General procedure for the synthesis of N-Boc-azetidine-3-carboxamide from 1-Boc-azetidine-3-carboxylic acid: 1-[(tert-butoxy)carbonyl]azetidine-3-carboxylic acid (4.96 g, 24.65 mmol) and triethylamine (TEA, 5.84 mL, 42.0 mmol) were dissolved in tetrahydrofuran (THF, 60 mL) and the the mixture was cooled to -20 °C. Isobutyl chloroformate (4.8 mL, 37.0 mmol) was added slowly with stirring, followed by stirring the reaction mixture at -10 °C for 15 min. 28% ammonia (7.46 mL, 394 mmol) was added, then the mixture was gradually warmed to room temperature and stirring was continued for 1 hour. Upon completion of the reaction, the reaction was quenched with saturated sodium bicarbonate (NaHCO?) solution, the reaction mixture was filtered and concentrated under reduced pressure. The crude product was purified by fast column chromatography using 20-100% ethyl acetate (EtOAc)/heptane gradient elution and 1-4% methanol (MeOH)/ethyl acetate (EtOAc) elution sequentially to afford N-Boc-azetidine-3-carboxamide (3.99 g, 81% yield) as a white solid. The product was confirmed by 1H-NMR (CDCl?, 250 MHz) and HPLC-MS (Method A): 1H-NMR δ [ppm] = 5.47 (s, 2H), 4.22-4.01 (m, 4H), 3.34-3.15 (m, 1H), 1.46 (s, 9H); HPLC-MS [m/z]: 222.95 [M + Na ]+.
References
[1] Patent: WO2017/68089, 2017, A2. Location in patent: Page/Page column 234; 235
[2] Patent: US2014/121198, 2014, A1. Location in patent: Paragraph 0688; 0689
[3] Bioorganic and Medicinal Chemistry Letters, 2002, vol. 12, # 5, p. 757 - 761
[4] Patent: WO2010/60952, 2010, A1. Location in patent: Page/Page column 81
[5] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 10, p. 3037 - 3040
tert-butyl 3-carbaMoylazetidine-1-carboxylat Preparation Products And Raw materials
Raw materials
Preparation Products
tert-butyl 3-carbaMoylazetidine-1-carboxylat Suppliers
- Tel
- 13526569071
- sales@leadmedpharm.com
- Country
- China
- ProdList
- 7892
- Advantage
- 64
- Tel
- 021-58170097
- info@topbiochem.com
- Country
- China
- ProdList
- 9510
- Advantage
- 58
- Tel
- 0512-56316828 4008675858
- Fax
- +86-512-56316826
- sales@amateksci.com
- Country
- China
- ProdList
- 9874
- Advantage
- 55
- Tel
- 0512-63009836 18994340901
- Fax
- 0512-63006936
- helen@struchem.com
- Country
- China
- ProdList
- 3981
- Advantage
- 60
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 0512-56316828
- Fax
- 0512-56316826
- info@amateksci.com
- Country
- China
- ProdList
- 28785
- Advantage
- 58
- Tel
- 021-58950110 13124863828
- Fax
- 021-20922272
- sales@linkchem.cn
- Country
- China
- ProdList
- 2998
- Advantage
- 58
- Tel
- 86-0573-85866609 13325730825
- Fax
- 0573-85866609
- 945717149@qq.com
- Country
- China
- ProdList
- 8593
- Advantage
- 58
- Tel
- 025-66061636 18013972705
- Fax
- (3)02557626880
- qqyang@aikonchem.com
- Country
- China
- ProdList
- 15814
- Advantage
- 58
- Tel
- +1-5166625404;
- Fax
- 1-516-927-0118
- Info@alfa-chemistry.com
- Country
- United States
- ProdList
- 20405
- Advantage
- 58