3-Trifluoromethyl-piperazine-1-carboxylic acid tert-butyl ester

Product Name: 3-Trifluoromethyl-piperazine-1-carboxylic acid tert-butyl ester
CAS No.: 886779-69-7
Chemical Name: 3-Trifluoromethyl-piperazine-1-carboxylic acid tert-butyl ester
Synonyms: 1-Boc-3-(trifluoromethyl)piperazine;tert-butyl 3-(trifluoromethyl)piperazine-1-carboxylate;1-Piperazinecarboxylic acid, 3-(trifluoromethyl)-, 1,1-dimethylethyl ester
CBNumber: CB03048801
Molecular Formula: C10H17F3N2O2
Formula Weight: 254.25
MOL File: 886779-69-7.mol

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3-Trifluoromethyl-piperazine-1-carboxylic acid tert-butyl ester Property

Boiling point:: 263.4±35.0 °C(Predicted)
Density: 1.189±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 5.95±0.40(Predicted)
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: 4565AJ
Product name: tert-Butyl3-(trifluoromethyl)piperazine-1-carboxylate
Packaging: 1g
Price: $917
Updated: 2021/12/16

J&W Pharmlab

Product number: 65R0282
Product name: 3-Trifluoromethyl-piperazine-1-carboxylicacidtert-butylester
Purity: 96%
Packaging: 5g
Price: $1998
Updated: 2021/12/16

Ambeed

Product number: A564989
Product name: tert-Butyl3-(trifluoromethyl)piperazine-1-carboxylate
Purity: 95%
Packaging: 50mg
Price: $122
Updated: 2021/12/16

J&W Pharmlab

Product number: 65R0282
Product name: 3-Trifluoromethyl-piperazine-1-carboxylicacidtert-butylester
Purity: 96%
Packaging: 50mg
Price: $131
Updated: 2021/12/16

J&W Pharmlab

Product number: 65R0282
Product name: 3-Trifluoromethyl-piperazine-1-carboxylicacidtert-butylester
Purity: 96%
Packaging: 100mg
Price: $162
Updated: 2021/12/16

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3-Trifluoromethyl-piperazine-1-carboxylic acid tert-butyl ester Chemical Properties,Usage,Production

Synthesis

24424-99-5

131922-05-9

886779-69-7

To a solution of 2-(trifluoromethyl)piperazine (135 mg, 0.876 mmol) in dichloromethane (6 mL) was added di-tert-butyl dicarbonate (0.224 mL, 0.963 mmol) and the reaction mixture was stirred for 3 hours at room temperature. After completion of the reaction, the mixture was concentrated and the residue was purified by silica gel column chromatography (eluent: 0-100% hexane solution of ethyl acetate) to afford 1-Boc-3-trifluoromethylpiperazine (200 mg, 0.787 mmol, 90% yield) as a light yellow solid. Mass spectrometry (ES+) analysis: the theoretical value of C10H17F3N2O2 was 254 and the measured value was 155 [M+H]+ - Boc group.

References

[1] Patent: WO2018/136887, 2018, A1. Location in patent: Page/Page column 122
[2] Patent: WO2014/175621, 2014, A1. Location in patent: Paragraph 662; 663; 664

3-Trifluoromethyl-piperazine-1-carboxylic acid tert-butyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Trifluoromethyl-piperazine-1-carboxylic acid tert-butyl ester Suppliers

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886779-69-7