Erlotinib D6 HCl

Product Name: Erlotinib D6 HCl
CAS No.: 1189953-78-3
Chemical Name: Erlotinib D6 HCl
Synonyms: Erlotinib D6;OSI-774 D6 hydrochloride;Erlotiniβ-d6 Hydrochloride;CP-358774 D6 hydrochloride;NSC 718781 D6 hydrochloride;[2H6]-Erlotinib Hydrochloride;Erlotinib Hydrochloride Impurity G
CBNumber: CB03049808
Molecular Formula: C22H18ClD6N3O4
Formula Weight: 435.933630668
MOL File: 1189953-78-3.mol

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Erlotinib D6 HCl Property

storage temp.: Store at -20°C
solubility: DMSO: slightly, heated,Methanol: slightly soluble
form: A solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 22101
Product name: Erlotinib-d6 (hydrochloride)
Purity: ≥99% deuterated forms (d1-d6)
Packaging: 1mg
Price: $279
Updated: 2024/03/01

TRC

Product number: E625002
Product name: Erlotinib-d6Hydrochloride
Packaging: 1mg
Price: $145
Updated: 2021/12/16

AK Scientific

Product number: 7728DG
Product name: ErlotinibD6Hydrochloride
Packaging: 1mg
Price: $409
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: RDL0006809
Product name: ERLOTINIB-D6-HYDROCHLORIDE
Purity: 95.00%
Packaging: 10MG
Price: $1871.1
Updated: 2021/12/16

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Erlotinib D6 HCl Chemical Properties,Usage,Production

Description

Erlotinib-d₆ (hydrochloride) contains six deuterium atoms located on the methoxy group. It is intended for use as an internal standard for the quantification of erlotinib by GC- or LC-MS. Erlotinib is a tyrosine kinase inhibitor that acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity (IC₅₀ = 2.5 μM). This inhibits tumor growth in human head and neck carcinoma (HN5) tumor xenografts in mice with an ED₅₀ value of 9 mg/kg. Erlotinib also suppresses cyclin-dependent kinase 2 (Cdk2) activity in breast cancer cells (IC₅₀ = 4.6 μM) and JAK2 mutant JAK2^V617F (IC₅₀ = 5 μM), which is associated with polycythemia vera, idiopathic myelofibrosis, and essential thrombocythemia. Formulations containing erlotinib are used to treat certain forms of cancer, including non-small cell lung cancer.

Uses

Erlotinib D6 HCl is a Selective epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor, Antineoplastic.;Labeled Erlotinib, intended for use as an internal standard for the quantification of Erlotinib by GC- or LC-mass spectrometry.

Erlotinib D6 HCl Preparation Products And Raw materials

Raw materials

Preparation Products

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Erlotinib D6 HCl Suppliers

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Erlotinib D6

Erlotinib Hydrochloride Impurity G

[2H6]-Erlotinib Hydrochloride

CP-358774 D6 hydrochloride

NSC 718781 D6 hydrochloride

OSI-774 D6 hydrochloride

Erlotiniβ-d6 Hydrochloride

1189953-78-3