Erlotinib Hydrochloride iMpurity

Product Name: Erlotinib Hydrochloride iMpurity
CAS No.: 882420-22-6
Chemical Name: Erlotinib Hydrochloride iMpurity
Synonyms: OSI-356;Erlotinib Chloro;Hydroxy Erlotinib;4-Hydroxy Erlotinib;Erlotinib Impurity 10;Erlotinib Impurity 17;Erlotinib Impurity 14;Erlotinib metabolite -2;Erlotinib Hydrochloride IMP;Erlotinib 4-Hydroxy Metabolite
CBNumber: CB22669443
Molecular Formula: C22H23N3O5
Formula Weight: 409.44
MOL File: 882420-22-6.mol

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Erlotinib Hydrochloride iMpurity Property

CAS DataBase Reference: 882420-22-6

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Hazard and Precautionary Statements (GHS)

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Erlotinib Hydrochloride iMpurity Chemical Properties,Usage,Production

Synthesis

A mixture of N'-[2-cyano-4,5-bis(2-methoxyethoxy)phenyl]-N,N-dimethyl-formamidine (compound of Formula II) 60g, with m-aminophenylacetylene (compound of Formula III) 30g, and acetic acid 300mL, was heated with stirring at a temperature of 95~105?? for 20~40min; cooled down to 85~90??, and dropwise added 4:1 volume ratio of tert-butanol/water mixed solvent 60mL, stirring the reaction under heat preservation for 25min; the reaction was completed, cooled to room temperature, and the reaction solution was concentrated under reduced pressure to obtain about 91g of the crude product containing the target (formula I); using column chromatography, the eluent was dichloromethane/methanol=60:1 (v/v), and the formula I compounds in the crude product were subjected to column chromatography to obtain an isolate of about 4.1g. HPLC The purity was 96.2%. About 4.1 g of the above isolate was added to the mixed solvent of isopropanol and ethyl acetate, isopropanol: ethyl acetate=4:1 (v/v), heated to reflux, all dissolved and then filtered while hot, and the filtrate was left to precipitate crystals for 7~8h at -5~0??C, dried, to obtain a high purity of erlotinib impurity of about 3.7 g. The purity of HPLC was 99.30%.

Erlotinib Hydrochloride iMpurity Preparation Products And Raw materials

Raw materials

Preparation Products

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882420-22-6, Erlotinib Hydrochloride iMpurityRelated Search:

Erlotinib 2'-Deoxy-L-thymidine Levetiracetam Trimebutine maleate Erlotinib iMpurity 2 Erlotinib 7-O-DesMethoxy-7-O-chloroethyl Erlotinib Hydrochloride DesMethyl Erlotinib Carboxylate Acid Erlotinib Erlotinib hydrochloride Erlotinib iMpurity B METHYL ESTER, 4,5-BIS(2-METHOXYETHOXY)-2-NITROBENZOIC ACID 4-CHLORO-7-(2-CHLORO-ETHOXY)-6-(2-METHOXY-ETHOXY)-QUINAZOLINE 6,7-bis(2-methoxyethoxy)-N-phenylquinazolin-4-amine DesMethyl Erlotinib Carboxylate Acid OSI 413 Benzoic acid, 3,4-bis(2-methoxyethoxy)-, methyl ester Erlotinib Impurity 20

Erlotinib Chloro

3-Ethynylailine Hydrochloride 1

4-Hydroxy Erlotinib

Erlotinib Impurity 10

Erlotinib Impurity 13 Hydrobromide

Erlotinib Impurity 14

Erlotinib Impurity 17

Erlotinib 4-Hydroxy Metabolite

Erlotinib Hydrochloride IMP

Erlotinib impurity 6/Erlotinib Hydroxy Metabolite/4-Hydroxy Erlotinib/4-((6,7-bis(2-methoxyethoxy)quinazolin-4-yl)amino)-2-ethynylphenol

ethyl 2,6-diamino-3,4-bis(2-methoxyethoxy)benzoate dihydrochloride

OSI-356

Phenol, 4-[[6,7-bis(2-methoxyethoxy)-4-quinazolinyl]amino]-2-ethynyl-

(Z)-N-(3-(2-chlorovinyl)phenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine

Hydroxy Erlotinib

4-Hydroxy Erlotinib Hydrochloride

Erlotinib metabolite -2

882420-22-6

69450-89-9