ChemicalBook > CAS DataBase List > (S)-tert-butyl 2-((1R,2R)-3-(((1S,2R)-1-hydroxy-1-phenylpropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidine-1-carboxylate

(S)-tert-butyl 2-((1R,2R)-3-(((1S,2R)-1-hydroxy-1-phenylpropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidine-1-carboxylate

Product Name
(S)-tert-butyl 2-((1R,2R)-3-(((1S,2R)-1-hydroxy-1-phenylpropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidine-1-carboxylate
CAS No.
160800-65-7
Chemical Name
(S)-tert-butyl 2-((1R,2R)-3-(((1S,2R)-1-hydroxy-1-phenylpropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidine-1-carboxylate
Synonyms
Boc-Dap-NE;N-Boc-Dap-NE;BOC-Dap-NE, 10 mM in DMSO;Antibody-drug conjugates linkers,inhibit,ADC Linkers,BOC Dap NE,Inhibitor,BOCDapNE;(2R,3R)-3-[(S)-1-Boc-2-pyrrolidinyl]-N-[(1S,2R)-1-hydroxy-1-phenyl-2-propyl]-3-methoxy-2-methylpropanamide;tert-butyl (2S)-2-[(1R,2R)-2-{[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]carbamoyl}-1-methoxy-2-methylethyl]pyrrolidine-1-carboxylate;tert-butyl (S)-2-((1R,2R)-3-(((1S,2R)-1-hydroxy-1-phenylpropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidine-1-carboxylate;(S)-tert-butyl 2-((1R,2R)-3-(((1S,2R)-1-hydroxy-1-phenylpropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidine-1-carboxylate;1-Pyrrolidinecarboxylic acid, 2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-, 1,1-dimethylethyl ester, (2S)-
CBNumber
CB03053768
Molecular Formula
C23H36N2O5
Formula Weight
420.54
MOL File
160800-65-7.mol
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(S)-tert-butyl 2-((1R,2R)-3-(((1S,2R)-1-hydroxy-1-phenylpropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidine-1-carboxylate Property

Melting point:
55-57 °C
Boiling point:
589.1±50.0 °C(Predicted)
Density 
1.125±0.06 g/cm3(Predicted)
storage temp. 
2-8°C, stored under nitrogen
solubility 
DMSO: 100 mg/mL (237.79 mM)
pka
13.66±0.20(Predicted)
form 
Solid
color 
White to off-white
Water Solubility 
Water: < 0.1 mg/mL (insoluble)
InChIKey
XJDVGABQIFOWFC-SCQOQHIRSA-N
SMILES
N1(C(OC(C)(C)C)=O)CCC[C@H]1[C@H](OC)[C@@H](C)C(N[C@H](C)[C@@H](O)C1=CC=CC=C1)=O
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-M2968
Product name
Boc-Dap-NE
Packaging
1g
Price
$1400
Updated
2021/12/16
Ambeed
Product number
A104664
Product name
(S)-tert-Butyl2-((1R,2R)-3-(((1S,2R)-1-hydroxy-1-phenylpropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidine-1-carboxylate
Purity
98+%
Packaging
100mg
Price
$152
Updated
2021/12/16
Ambeed
Product number
A104664
Product name
(S)-tert-Butyl2-((1R,2R)-3-(((1S,2R)-1-hydroxy-1-phenylpropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidine-1-carboxylate
Purity
98+%
Packaging
250mg
Price
$284
Updated
2021/12/16
Ambeed
Product number
A104664
Product name
(S)-tert-Butyl2-((1R,2R)-3-(((1S,2R)-1-hydroxy-1-phenylpropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidine-1-carboxylate
Purity
98+%
Packaging
1g
Price
$710
Updated
2021/12/16
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(S)-tert-butyl 2-((1R,2R)-3-(((1S,2R)-1-hydroxy-1-phenylpropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidine-1-carboxylate Chemical Properties,Usage,Production

Uses

Boc-Dap-NE, a dipeptide, is a cleavable ADC linker for the synthesis of antibody-drug conjugates (ADCs).

Biological Activity

Boc-Dap-NE is a dipeptide used as a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs).

target

Cleavable

IC 50

Cleavable Linker

(S)-tert-butyl 2-((1R,2R)-3-(((1S,2R)-1-hydroxy-1-phenylpropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidine-1-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-tert-butyl 2-((1R,2R)-3-(((1S,2R)-1-hydroxy-1-phenylpropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidine-1-carboxylate Suppliers

China 82 United States 6 Global 88
YJ Pharma
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13962794339
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China
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Tianjin Chempharmatech Co.,Ltd.
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022-66211079 13212288319
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qq1405432731
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sales@chempharmatech.com
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China
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Huadong Microbiology Co., Ltd.
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15858880160
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dingya@eastchinapharm.com
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China
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Xirui Biotech (Suzhou) Co., Ltd
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15051477682 15851592819;
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China
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Shanghai Haoyuan Chemexpress Co., Ltd.
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021-58950125
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info@chemexpress.com
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Suzhou Highfine Biotech Co., Ltd
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Shanghai Topbiochem Technology Co., Ltd
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021-58170097 15801866362;
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Hygeia (Chengdu) pharmaceutical technique Co., Ltd
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028-84502008 13568869383
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028-66476329
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sales@hygeiapharm.com
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China
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Bide Pharmatech Ltd.
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+86-21-61629029
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product02@bidepharm.com
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160800-65-7, (S)-tert-butyl 2-((1R,2R)-3-(((1S,2R)-1-hydroxy-1-phenylpropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidine-1-carboxylateRelated Search:


  • (S)-tert-butyl 2-((1R,2R)-3-(((1S,2R)-1-hydroxy-1-phenylpropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidine-1-carboxylate
  • 1-Pyrrolidinecarboxylic acid, 2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-, 1,1-dimethylethyl ester, (2S)-
  • Boc-Dap-NE
  • N-Boc-Dap-NE
  • Antibody-drug conjugates linkers,inhibit,ADC Linkers,BOC Dap NE,Inhibitor,BOCDapNE
  • (2R,3R)-3-[(S)-1-Boc-2-pyrrolidinyl]-N-[(1S,2R)-1-hydroxy-1-phenyl-2-propyl]-3-methoxy-2-methylpropanamide
  • tert-butyl (S)-2-((1R,2R)-3-(((1S,2R)-1-hydroxy-1-phenylpropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidine-1-carboxylate
  • tert-butyl (2S)-2-[(1R,2R)-2-{[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]carbamoyl}-1-methoxy-2-methylethyl]pyrrolidine-1-carboxylate
  • BOC-Dap-NE, 10 mM in DMSO
  • 160800-65-7
  • ADC LINKER
  • ADCs Linkers
  • ADCs