ETC-159

Product Name: ETC-159
CAS No.: 1638250-96-0
Chemical Name: ETC-159
Synonyms: CS-1584;ETC-159;ETC1922159;ETC 1922159;ETC-1922159;ETC159 (ETC192215);ETC-159 (ETC-1922159);ETC-159, 10 mM in DMSO;ETC 159;ETC159;ETC 1922159;ETC-1922159;ETC1922159;ETC-159;ETC 159;ETC159;ETC 1922159;ETC-1922159;ETC1922159
CBNumber: CB03053889
Molecular Formula: C19H17N7O3
Formula Weight: 391.38
MOL File: 1638250-96-0.mol

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ETC-159 Property

Density: 1.47±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 33 mg/ml; DMSO: 33 mg/ml; DMSO:PBS (pH 7.2) (1:7): 0.12 mg/ml
form: A crystalline solid
pka: 11.28±0.70(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H371May cause damage to organs

H372Causes damage to organs through prolonged or repeated exposure

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P391Collect spillage. Hazardous to the aquatic environment

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 24104
Product name: ETC-159
Purity: ≥95%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 24104
Product name: ETC-159
Purity: ≥95%
Packaging: 5mg
Price: $63
Updated: 2024/03/01

Cayman Chemical

Product number: 24104
Product name: ETC-159
Purity: ≥95%
Packaging: 10mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 24104
Product name: ETC-159
Purity: ≥95%
Packaging: 25mg
Price: $230
Updated: 2024/03/01

TRC

Product number: T293433
Product name: 1,2,3,6-Tetrahydro-1,3-dimethyl-2,6-dioxo-N-(6-phenyl-3-pyridazinyl)-7H-purine-7-acetamide
Packaging: 100mg
Price: $790
Updated: 2021/12/16

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ETC-159 Chemical Properties,Usage,Production

Uses

1,2,3,6-Tetrahydro-1,3-dimethyl-2,6-dioxo-N-(6-phenyl-3-pyridazinyl)-7H-purine-7-acetamide is a novel potent PORCN inhibitor that blocks the secretion and activity of all Wnts.

in vivo

ETC-159 inhibits mouse PORCN with an IC₅₀ of 18.1 nM, whereas the IC50 for Xenopus Porcn is approximately four fold higher (70 nM). ETC-159 is remarkably effective in treating RSPO-translocation bearing colorectal cancer (CRC) patient-derived xenografts. ETC-159 exhibits good oral pharmacokinetics in mice allowing preclinical evaluation via oral administration. After a single oral dose of 5 mg/kg, ETC-159 is rapidly absorbed into the blood with a T_max of ~0.5 h and oral bioavailability of 100%^[1].

ETC-159 Preparation Products And Raw materials

Raw materials

Preparation Products

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ETC-159 Suppliers

China 60 India 1 United States 9 Global 70

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

AdooQ Bioscience CHINA

Tel: 025-58849295 18951903616;
Fax: 025-68650336
Email: info@adooq.cn
Country: China
ProdList: 2990
Advantage: 60

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4768
Advantage: 55

D&C Chemicals

Tel: +86-21-58447131
Fax: +86-21-61642470
Email: 1724405207@qq.com
Country: China
ProdList: 472
Advantage: 55

Guangzhou QiYun Biotechnology Co., Ltd.

Tel: 020-61288194 61288195
Fax: 020-61288700
Email: 505721671@qq.com
Country: China
ProdList: 3866
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 8011
Advantage: 55

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
Advantage: 62

1638250-96-0, ETC-159Related Search:

N,N-Dimethylaniline N,N-Dimethylcyclohexylamine

ETC-159

1,2,3,6-Tetrahydro-1,3-dimethyl-2,6-dioxo-N-(6-phenyl-3-pyridazinyl)-7H-purine-7-acetamide

2-(1,3-dimethyl-2,6-dioxopurin-7-yl)-N-(6-phenylpyridazin-3-yl)acetamide

CS-1584

ETC 1922159

ETC-159;ETC 159;ETC159;ETC 1922159;ETC-1922159;ETC1922159

ETC1922159

ETC-1922159

ETC 159;ETC159;ETC 1922159;ETC-1922159;ETC1922159

7H-Purine-7-acetamide, 1,2,3,6-tetrahydro-1,3-dimethyl-2,6-dioxo-N-(6-phenyl-3-pyridazinyl)-

ETC159 (ETC192215)

ETC1922159,ETC-159,ETC 1922159,Inhibitor,inhibit,Wnt,Porcupine

2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(6-phenylpyridazin-3-yl)acetamide

ETC-159, 10 mM in DMSO

ETC-159 (ETC-1922159)

1638250-96-0