1-methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrilehydrochloride

Product Name: 1-methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrilehydrochloride
CAS No.: 1643141-20-1
Chemical Name: 1-methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrilehydrochloride
Synonyms: EOS-60596;PF06463922 impurity;2-METHYL-5-(METHYLAMINOMETHYL)PYRAZOLE-3-CARBONITRILE HCL;1-methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrileh...;1-methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrile HCl;2-methyl-5-(methylaminomethyl)pyrazole-3-carbonitrile hydrochloride;Methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrilehydrochloridesalt;1H-Pyrazole-5-carbonitrile, 1-methyl-3-[(methylamino)methyl]-, hydrochloride;1-Methyl-3-[(methylamino)methyl]-1H-pyrazole-5-carbonitrile hydrochloride (1:1);1H-Pyrazole-5-carbonitrile, 1-methyl-3-[(methylamino)methyl]-, hydrochloride (1:1)
CBNumber: CB03054477
Molecular Formula: C7H11ClN4
Formula Weight: 186.64
MOL File: 1643141-20-1.mol

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

More

Less

N-Bromosuccinimide Price

Ambeed

Product number: A838499
Product name: 1-Methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrilehydrochloride
Purity: 98%
Packaging: 100mg
Price: $15
Updated: 2021/12/16

Ambeed

Product number: A838499
Product name: 1-Methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrilehydrochloride
Purity: 98%
Packaging: 250mg
Price: $25
Updated: 2021/12/16

Chemenu

Product number: CM331110
Product name: 1-Methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrilehydrochloride
Purity: 95%+
Packaging: 100mg
Price: $58
Updated: 2021/12/16

Ambeed

Product number: A838499
Product name: 1-Methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrilehydrochloride
Purity: 98%
Packaging: 1g
Price: $60
Updated: 2021/12/16

Chemenu

Product number: CM331110
Product name: 1-Methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrilehydrochloride
Purity: 95%+
Packaging: 250mg
Price: $93
Updated: 2021/12/16

More

Less

1-methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrilehydrochloride Chemical Properties,Usage,Production

Uses

1-Methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrile hydrochloride can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development processes and chemical production processes.

Synthesis

To compound 19 (7.0 kg, 26.1 mol) in DCM (30 L) at O℃ was added triethylamine (5.85 kg, 57.8 mol). The mixture was further cooled to -6°C then trifluoroacetic anhydride (5.85 kg, 27.8 mol) added over 90 minutes [temp kept 0 to 5°C], TLC assay showed the reaction was incomplete. Additional triethylamine (4.1 kg, 40.5 mol) and trifluoroacetic acid (4.1 kg, 19.5 mol) 10 were added over 2 hours until TLC showed complete reaction. The reaction mixture was quenched in to water (40 L) [temp to 23°C], The layers were separated and the aqueous re- extracted with DCM (8 L). The organic layers were sequentially washed with brine (7 L), filtered through a pad of silica (3 kg) and eluted with DCM (10 L). The filtrate was evaporated and chromatographed (9 kg silica, eluent 10-30% EtOAc in hexane). Product fractions were 15 evaporated and azeotroped with IPA to afford compound 20 (6.86 kg, ~94 wt%, 25.8 mol, 99%) as an orange oil. To compound 20 (6.86 kg, ~94 wt%, 25.8 mol) in IPA (35 L) at 17°C was added 37% hydrochloric acid (6.4 L, 77.4 mol). The mixture was heated to 35°C overnight then concentrated 20 to a moist solid and residual water azeotroped with additional IPA (8 L). The resulting moist solid was triturated with MTBE (12 L) at 45°C for 30 minutes then cooled to 20°C and filtered, washing with MTBE (5 L). The solids were dried under vacuum at 45°C to afford compound 21 (4.52 kg, 24.2 mol, 94%) as a white solid. 1H-NMR was consistent with desired product; mp 203-205°C; HPLC 99.3%.

1-methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrilehydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

1-methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrilehydrochloride Suppliers

China 93 India 1 Global 94

Shanghai Hope Chem Co., Ltd.，

Tel: +21-18501659228 18501659228
Fax: sales@hope-chem.com
Email: info@hope-chem.com
Country: China
ProdList: 429
Advantage: 55

Hangzhou Chemtrue Bio-Tech Co.,Ltd.

Tel: 0571-86828652 19967494293
Fax: 0571-83522824
Email: sales@chemtrue-bio.com
Country: China
ProdList: 314
Advantage: 58

Wuhan Shenxinda Chemical Technology Co., Ltd.

Tel: 27-87509949 13419524390
Email: sdg9136@163.com
Country: China
ProdList: 118
Advantage: 58

Suzhou Ryan Pharmaceutical Technology Co., Ltd.

Tel: 0512-68780025,68780026 18962125825
Email: sales@ryanchem.com
Country: China
ProdList: 161
Advantage: 62

ChengDu TongChuangYuan Pharmaceutical Co.Ltd

Tel: 28-83379370 13880556291
Fax: 028-87747383
Email: tcy@tcypharm.com
Country: China
ProdList: 511
Advantage: 57

Wuhan Sunrise Technology Development Co., Ltd.

Tel: 027-027-83314682 13554138826
Fax: +86 (27) 8331-4682
Email: whsrtech@vip.163.com
Country: China
ProdList: 300
Advantage: 62

SHANGHAI YINGRUI CHEMICAL TECHNOLOGY CO.,LTD.

Tel: 021-34666753 13311639313
Fax: +86-21-34979012
Email: info@shyrchem.com
Country: China
ProdList: 570
Advantage: 55

Suli Pharmaceutical Technology Co., Ltd.

Tel: 021-021-58086325-8012-8012 13636568474
Fax: 021-51972827
Email: yingjie.zhang@suli.com
Country: China
ProdList: 103
Advantage: 58

Suzhou Sino Rare Chemical Co., Ltd.

Tel: 0512-62857507
Fax: +86-512-62857507
Email: sales@sinorarechem.com
Country: China
ProdList: 981
Advantage: 58

Shanghai YuanQi Biotechnology Co., Ltd.

Tel: +86-2332782371 +86-18120098618
Email: sales@adobechem.com
Country: China
ProdList: 1250
Advantage: 50

More

Less

View Lastest Price from 1-methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrilehydrochloride manufacturers

Henan Fengda Chemical Co., Ltd

Product: 1-methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrilehydrochloride 1643141-20-1
Price: US $5.00-0.10/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-09

Nanjing Fred Technology Co., Ltd

Product: 1-methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrile hydrochloridesalt 1643141-20-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1 ton
Release date: 2023-12-29

Suzhou Ryan Pharmachem Technology Co.,Ltd.

Product: 1-methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrilehydrochloridesalt 1643141-20-1
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: kg grade
Release date: 2023-05-08

1643141-20-1, 1-methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrilehydrochlorideRelated Search:

Benzoic acid, 2-[(1R)-1-[(2-amino-5-bromo-3-pyridinyl)oxy]ethyl]-4-fluoro- 1-Methyl-4-pyrazole boronic acid pinacol ester

EOS-60596

1-methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrile HCl

1H-Pyrazole-5-carbonitrile, 1-methyl-3-[(methylamino)methyl]-, hydrochloride

1H-Pyrazole-5-carbonitrile, 1-methyl-3-[(methylamino)methyl]-, hydrochloride (1:1)

2-METHYL-5-(METHYLAMINOMETHYL)PYRAZOLE-3-CARBONITRILE HCL

1-methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrileh...

2-methyl-5-(methylaminomethyl)pyrazole-3-carbonitrile hydrochloride

1-Methyl-3-[(methylamino)methyl]-1H-pyrazole-5-carbonitrile hydrochloride (1:1)

Methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrilehydrochloridesalt

PF06463922 impurity

1643141-20-1