ChemicalBook > CAS DataBase List > 1-methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrilehydrochloride

1-methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrilehydrochloride

Product Name
1-methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrilehydrochloride
CAS No.
1643141-20-1
Chemical Name
1-methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrilehydrochloride
Synonyms
EOS-60596;PF06463922 impurity;2-METHYL-5-(METHYLAMINOMETHYL)PYRAZOLE-3-CARBONITRILE HCL;1-methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrileh...;1-methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrile HCl;2-methyl-5-(methylaminomethyl)pyrazole-3-carbonitrile hydrochloride;Methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrilehydrochloridesalt;1H-Pyrazole-5-carbonitrile, 1-methyl-3-[(methylamino)methyl]-, hydrochloride;1-Methyl-3-[(methylamino)methyl]-1H-pyrazole-5-carbonitrile hydrochloride (1:1);1H-Pyrazole-5-carbonitrile, 1-methyl-3-[(methylamino)methyl]-, hydrochloride (1:1)
CBNumber
CB03054477
Molecular Formula
C7H11ClN4
Formula Weight
186.64
MOL File
1643141-20-1.mol
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Ambeed
Product number
A838499
Product name
1-Methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrilehydrochloride
Purity
98%
Packaging
100mg
Price
$15
Updated
2021/12/16
Ambeed
Product number
A838499
Product name
1-Methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrilehydrochloride
Purity
98%
Packaging
250mg
Price
$25
Updated
2021/12/16
Chemenu
Product number
CM331110
Product name
1-Methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrilehydrochloride
Purity
95%+
Packaging
100mg
Price
$58
Updated
2021/12/16
Ambeed
Product number
A838499
Product name
1-Methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrilehydrochloride
Purity
98%
Packaging
1g
Price
$60
Updated
2021/12/16
Chemenu
Product number
CM331110
Product name
1-Methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrilehydrochloride
Purity
95%+
Packaging
250mg
Price
$93
Updated
2021/12/16
More
Less

1-methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrilehydrochloride Chemical Properties,Usage,Production

Uses

1-Methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrile hydrochloride can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development processes and chemical production processes.

Synthesis

To compound 19 (7.0 kg, 26.1 mol) in DCM (30 L) at O℃ was added triethylamine (5.85 kg, 57.8 mol). The mixture was further cooled to -6°C then trifluoroacetic anhydride (5.85 kg, 27.8 mol) added over 90 minutes [temp kept 0 to 5°C], TLC assay showed the reaction was incomplete. Additional triethylamine (4.1 kg, 40.5 mol) and trifluoroacetic acid (4.1 kg, 19.5 mol) 10 were added over 2 hours until TLC showed complete reaction. The reaction mixture was quenched in to water (40 L) [temp to 23°C], The layers were separated and the aqueous re- extracted with DCM (8 L). The organic layers were sequentially washed with brine (7 L), filtered through a pad of silica (3 kg) and eluted with DCM (10 L). The filtrate was evaporated and chromatographed (9 kg silica, eluent 10-30% EtOAc in hexane). Product fractions were 15 evaporated and azeotroped with IPA to afford compound 20 (6.86 kg, ~94 wt%, 25.8 mol, 99%) as an orange oil. To compound 20 (6.86 kg, ~94 wt%, 25.8 mol) in IPA (35 L) at 17°C was added 37% hydrochloric acid (6.4 L, 77.4 mol). The mixture was heated to 35°C overnight then concentrated 20 to a moist solid and residual water azeotroped with additional IPA (8 L). The resulting moist solid was triturated with MTBE (12 L) at 45°C for 30 minutes then cooled to 20°C and filtered, washing with MTBE (5 L). The solids were dried under vacuum at 45°C to afford compound 21 (4.52 kg, 24.2 mol, 94%) as a white solid. 1H-NMR was consistent with desired product; mp 203-205°C; HPLC 99.3%.

1-methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrilehydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

1-methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrilehydrochloride Suppliers

China 95 India 1 Global 96
Shanghai Hope Chem Co., Ltd.，
Tel
+21-18501659228 18501659228
Fax
sales@hope-chem.com
Email
info@hope-chem.com
Country
China
ProdList
436
Advantage
55
Hangzhou Chemtrue Bio-Tech Co.,Ltd.
Tel
0571-86828652 18857119830
Fax
0571-83522824
Email
sales@chemtrue-bio.com
Country
China
ProdList
314
Advantage
58
Wuhan Shenxinda Chemical Technology Co., Ltd.
Tel
27-87509949 13419524390
Email
sdg9136@163.com
Country
China
ProdList
118
Advantage
58
Suzhou Ryan Pharmaceutical Technology Co., Ltd.
Tel
0512-68780025,68780026 18962125825
Email
sales@ryanchem.com
Country
China
ProdList
161
Advantage
62
ChengDu TongChuangYuan Pharmaceutical Co.Ltd
Tel
28-83379370 13880556291
Fax
028-87747383
Email
tcy@tcypharm.com
Country
China
ProdList
511
Advantage
57
Wuhan Sunrise Technology Development Co., Ltd.
Tel
027-027-83314682 13554138826
Fax
+86 (27) 8331-4682
Email
whsrtech@vip.163.com
Country
China
ProdList
300
Advantage
62
SHANGHAI YINGRUI CHEMICAL TECHNOLOGY CO.,LTD.
Tel
021-34666753 13311639313
Fax
+86-21-34979012
Email
info@shyrchem.com
Country
China
ProdList
571
Advantage
55
Suli Pharmaceutical Technology Co., Ltd.
Tel
021-021-58086325-8012-8012 13636568474
Fax
021-51972827
Email
yingjie.zhang@suli.com
Country
China
ProdList
103
Advantage
58
Suzhou Sino Rare Chemical Co., Ltd.
Tel
0512-62857507
Fax
+86-512-62857507
Email
sales@sinorarechem.com
Country
China
ProdList
984
Advantage
58
Shanghai YuanQi Biotechnology Co., Ltd.
Tel
+86-2332782371 +86-18120098618
Email
sales@adobechem.com
Country
China
ProdList
1250
Advantage
50
Lanzhou Angeli Biochemical Technology Co., Ltd.
Tel
0931-8235634 13321316780
Fax
+86(931) 4873122
Email
1455540579@qq.com
Country
China
ProdList
959
Advantage
55
Shanghai Shanyuan pharmaceutical technology co., LTD
Tel
021-31761238 13167072949
Fax
021-31761238
Email
3146446224@qq.com
Country
China
ProdList
1610
Advantage
55
Cangzhou Enke Pharma-tech Co., Ltd.
Tel
0317-5296180 15533709196
Fax
0317-5106596
Email
sale@enkepharma.com
Country
China
ProdList
1647
Advantage
55
ShangHai Biochempartner Co.,Ltd
Tel
17754423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8011
Advantage
62
ChengDu TongChuangYuan Pharmaceutical Co.Ltd
Tel
028-83379370 13880556291
Fax
028-87747383
Email
tcy@tcypharm.com
Country
China
ProdList
5469
Advantage
58
Jinan elephant international trading co., LTD
Tel
Fax
-
Email
13006575422@163.com
Country
China
ProdList
6357
Advantage
58
Zhengzhou Acme Chemical Co., Ltd.
Tel
0371-0371-55629727 13323845623
Fax
037155629727
Email
2885676761@qq.com
Country
China
ProdList
9859
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131981
Advantage
58
Shanghai Zhen Li Biological Technology Co., Ltd
Tel
021-16621358918; 18516310516
Fax
13045646768
Email
zhenlipharma888@163.com
Country
China
ProdList
1981
Advantage
58
Capot Chemical Co.,Ltd.
Tel
571-85586718 +8613336195806
Fax
+86-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
29797
Advantage
60
Aikon International Limited
Tel
025-66113011 18112977050
Fax
(5)02557626880
Email
cb6@aikonchem.com
Country
China
ProdList
15495
Advantage
58
ShangHai Book Chemical Co., Ltd.
Tel
15001988657 15802146997
Email
info@bookchemicals.com
Country
China
ProdList
1010
Advantage
58
Jinan Kabotang Biological Technology Co.,Ltd.
Tel
0531-61320525 15866703830
Email
495745175@qq.com
Country
China
ProdList
6640
Advantage
58
SuZhou Medinoah Co.,LTD.
Tel
0512-0512-69561983 13914027025
Fax
0512-69561982
Email
he_qf@medinoah.com
Country
China
ProdList
3394
Advantage
58
Zaozhuang RunAn Pharmaceutical New Materials Co., Ltd.
Tel
17753120863
Fax
0632-5187987
Email
15318096028@163.com
Country
China
ProdList
43
Advantage
58
Chengdu dashengge pharmaceutical technology co., LTD
Tel
13880556291
Fax
028-87747383
Email
fuwei@tcypharm.com
Country
China
ProdList
236
Advantage
58
Shanghai zhigan biotechnology co., LTD
Tel
Email
zhiqianbio@126.com
Country
China
ProdList
19785
Advantage
58
Tianjin Kaifu Pharmaceutical Technology Co., Ltd.
Tel
18081075745
Email
chemflowtech@sina.com
Country
China
ProdList
1886
Advantage
58
Jinan Carbotang Biotech Co.,Ltd.
Tel
+8615866703830
Email
figo.gao@foxmail.com
Country
China
ProdList
7019
Advantage
58
Nanjing Meihao Pharmaceutical Technology Co., Ltd.
Tel
meitaochem@126.com
Email
meitaochem@126.com
Country
China
ProdList
19105
Advantage
58
ANHUI WITOP BIOTECH CO., LTD
Tel
+8615255079626
Email
eric@witopchemical.com
Country
China
ProdList
23556
Advantage
58
Shanghai UCHEM Inc.
Tel
+862156762820 +86-13564624040
Email
sales@myuchem.com
Country
China
ProdList
6708
Advantage
58
Hefei TNJ Chemical Industry Co.,Ltd.
Tel
0551-65418684 +8618949823763
Fax
0086-551-65418684
Email
sales@tnjchem.com
Country
China
ProdList
25363
Advantage
58
Labnetwork lnc.
Tel
+86-27-50766799 +8618062016861
Email
contact@labnetwork.com
Country
China
ProdList
19994
Advantage
58
Henan Weituxi Chemical Technology Co., Ltd.
Tel
0371-63284658 18135795563
Fax
QQ:2885349392
Email
2885349392@qq.com
Country
China
ProdList
10000
Advantage
58
Shanghai Yanze Chemical Co., Ltd.
Tel
021-13773155751 19901447308
Email
260924549@qq.com
Country
China
ProdList
8742
Advantage
58
Shanghai Payne Pharmaceutical Technology Co.Ltd
Tel
021-58123769 17721400256
Email
info@paynepharm.com
Country
China
ProdList
1285
Advantage
58
Shanghai Payne Pharmaceutical Technology Co.Ltd
Tel
021-58123769 18678586262
Email
info@paynepharm.com
Country
China
ProdList
1354
Advantage
58
Chengdu aibike Pharmaceutical Technology Co., Ltd
Tel
18428121256
Email
wangxinlongzy@163.com
Country
China
ProdList
22
Advantage
58
Neostar United (Changzhou) Industrial Co., Ltd.
Tel
+86-519-519-85557386
Fax
+0086-519-85557389
Email
marketing1@neostarunited.com
Country
China
ProdList
8348
Advantage
58
Chunchuang (Wuhan) Technology Co., Ltd
Tel
15342225168
Email
yutianchun2007@126.com
Country
China
ProdList
10002
Advantage
58
Shanghai Yuke Chemicals Co., Ltd
Tel
13818767334
Fax
QQ：14748090
Email
samwjf@163.com
Country
China
ProdList
164
Advantage
58
Xinyi Quren Biomedical Technology Co., Ltd
Tel
15801811306
Email
2924048582@qq.com
Country
China
ProdList
98
Advantage
58
Wuhan Topule
Tel
+86-02787215551 +86-19945035818
Fax
027-87215551
Email
2936752263@qq.com
Country
China
ProdList
7955
Advantage
58
Shanghai UCHEM Inc.
Tel
18939844854 18939844854
Fax
QQ3004479448
Email
sales6@myuchem.com
Country
China
ProdList
3317
Advantage
58
Wuhan Fortuna Chemical Co., Ltd
Tel
027-027-59207852 13308628970
Fax
QQ:2779667926
Email
buy@fortunachem.com
Country
China
ProdList
2645
Advantage
58
Wuhan Xinyang Ruihe Chemical Technology Co., Ltd.
Tel
13720181483 13720181483
Email
366443693@QQ.COM
Country
China
ProdList
3579
Advantage
58
Hunan Zhangjiajie Hengkang Biological Pharmaceutical Co., LTD
Tel
0731-85561023 18973109536
Email
hengkangapi@hengkangapi.com
Country
China
ProdList
336
Advantage
58
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 4008210725
Email
malulu@leyan.com
Country
China
ProdList
39997
Advantage
58
PharmaBlock Sciences (Nanjing), Inc.
Tel
025-86918232 4000255188
Fax
025 86918232
Email
sales_china@pharmablock.com
Country
China
ProdList
9792
Advantage
58
More
Less

View Lastest Price from 1-methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrilehydrochloride manufacturers

Nanjing Fred Technology Co., Ltd
Product
1-methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrile hydrochloridesalt 1643141-20-1
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1 ton
Release date
2023-12-29
Henan Fengda Chemical Co., Ltd
Product
1-methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrilehydrochloride 1643141-20-1
Price
US $5.00-0.10/KG
Min. Order
1KG
Purity
98%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-09
Suzhou Ryan Pharmachem Technology Co.,Ltd.
Product
1-methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrilehydrochloridesalt 1643141-20-1
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
kg grade
Release date
2023-05-08

1643141-20-1, 1-methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrilehydrochlorideRelated Search:

Benzoic acid, 2-[(1R)-1-[(2-amino-5-bromo-3-pyridinyl)oxy]ethyl]-4-fluoro- 1-Methyl-4-pyrazole boronic acid pinacol ester

  • EOS-60596
  • 1-methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrile HCl
  • 1H-Pyrazole-5-carbonitrile, 1-methyl-3-[(methylamino)methyl]-, hydrochloride
  • 1H-Pyrazole-5-carbonitrile, 1-methyl-3-[(methylamino)methyl]-, hydrochloride (1:1)
  • 2-METHYL-5-(METHYLAMINOMETHYL)PYRAZOLE-3-CARBONITRILE HCL
  • 1-methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrileh...
  • 2-methyl-5-(methylaminomethyl)pyrazole-3-carbonitrile hydrochloride
  • 1-Methyl-3-[(methylamino)methyl]-1H-pyrazole-5-carbonitrile hydrochloride (1:1)
  • Methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrilehydrochloridesalt
  • PF06463922 impurity
  • 1643141-20-1