ChemicalBook > CAS DataBase List > 1-methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrilehydrochloride

1-methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrilehydrochloride

Product Name
1-methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrilehydrochloride
CAS No.
1643141-20-1
Chemical Name
1-methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrilehydrochloride
Synonyms
EOS-60596;PF06463922 impurity;2-METHYL-5-(METHYLAMINOMETHYL)PYRAZOLE-3-CARBONITRILE HCL;1-methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrileh...;1-methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrile HCl;2-methyl-5-(methylaminomethyl)pyrazole-3-carbonitrile hydrochloride;Methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrilehydrochloridesalt;1H-Pyrazole-5-carbonitrile, 1-methyl-3-[(methylamino)methyl]-, hydrochloride;1-Methyl-3-[(methylamino)methyl]-1H-pyrazole-5-carbonitrile hydrochloride (1:1);1H-Pyrazole-5-carbonitrile, 1-methyl-3-[(methylamino)methyl]-, hydrochloride (1:1)
CBNumber
CB03054477
Molecular Formula
C7H11ClN4
Formula Weight
186.64
MOL File
1643141-20-1.mol
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Ambeed
Product number
A838499
Product name
1-Methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrilehydrochloride
Purity
98%
Packaging
100mg
Price
$15
Updated
2021/12/16
Ambeed
Product number
A838499
Product name
1-Methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrilehydrochloride
Purity
98%
Packaging
250mg
Price
$25
Updated
2021/12/16
Chemenu
Product number
CM331110
Product name
1-Methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrilehydrochloride
Purity
95%+
Packaging
100mg
Price
$58
Updated
2021/12/16
Ambeed
Product number
A838499
Product name
1-Methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrilehydrochloride
Purity
98%
Packaging
1g
Price
$60
Updated
2021/12/16
Chemenu
Product number
CM331110
Product name
1-Methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrilehydrochloride
Purity
95%+
Packaging
250mg
Price
$93
Updated
2021/12/16
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1-methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrilehydrochloride Chemical Properties,Usage,Production

Uses

1-Methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrile hydrochloride can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development processes and chemical production processes.

Synthesis

To compound 19 (7.0 kg, 26.1 mol) in DCM (30 L) at O℃ was added triethylamine (5.85 kg, 57.8 mol). The mixture was further cooled to -6°C then trifluoroacetic anhydride (5.85 kg, 27.8 mol) added over 90 minutes [temp kept 0 to 5°C], TLC assay showed the reaction was incomplete. Additional triethylamine (4.1 kg, 40.5 mol) and trifluoroacetic acid (4.1 kg, 19.5 mol) 10 were added over 2 hours until TLC showed complete reaction. The reaction mixture was quenched in to water (40 L) [temp to 23°C], The layers were separated and the aqueous re- extracted with DCM (8 L). The organic layers were sequentially washed with brine (7 L), filtered through a pad of silica (3 kg) and eluted with DCM (10 L). The filtrate was evaporated and chromatographed (9 kg silica, eluent 10-30% EtOAc in hexane). Product fractions were 15 evaporated and azeotroped with IPA to afford compound 20 (6.86 kg, ~94 wt%, 25.8 mol, 99%) as an orange oil. To compound 20 (6.86 kg, ~94 wt%, 25.8 mol) in IPA (35 L) at 17°C was added 37% hydrochloric acid (6.4 L, 77.4 mol). The mixture was heated to 35°C overnight then concentrated 20 to a moist solid and residual water azeotroped with additional IPA (8 L). The resulting moist solid was triturated with MTBE (12 L) at 45°C for 30 minutes then cooled to 20°C and filtered, washing with MTBE (5 L). The solids were dried under vacuum at 45°C to afford compound 21 (4.52 kg, 24.2 mol, 94%) as a white solid. 1H-NMR was consistent with desired product; mp 203-205°C; HPLC 99.3%.

1-methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrilehydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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1-methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrilehydrochloride Suppliers

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View Lastest Price from 1-methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrilehydrochloride manufacturers

Nanjing Fred Technology Co., Ltd
Product
1-methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrile hydrochloridesalt 1643141-20-1
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1 ton
Release date
2023-12-29
Henan Fengda Chemical Co., Ltd
Product
1-methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrilehydrochloride 1643141-20-1
Price
US $5.00-0.10/KG
Min. Order
1KG
Purity
98%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-09
Suzhou Ryan Pharmachem Technology Co.,Ltd.
Product
1-methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrilehydrochloridesalt 1643141-20-1
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
kg grade
Release date
2023-05-08

1643141-20-1, 1-methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrilehydrochlorideRelated Search:

Benzoic acid, 2-[(1R)-1-[(2-amino-5-bromo-3-pyridinyl)oxy]ethyl]-4-fluoro- 1-Methyl-4-pyrazole boronic acid pinacol ester

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  • 1H-Pyrazole-5-carbonitrile, 1-methyl-3-[(methylamino)methyl]-, hydrochloride
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  • 1-Methyl-3-[(methylamino)methyl]-1H-pyrazole-5-carbonitrile hydrochloride (1:1)
  • Methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrilehydrochloridesalt
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  • 1643141-20-1