1-methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrilehydrochloride

Product Name: 1-methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrilehydrochloride
CAS No.: 1643141-20-1
Chemical Name: 1-methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrilehydrochloride
Synonyms: EOS-60596;PF06463922 impurity;2-METHYL-5-(METHYLAMINOMETHYL)PYRAZOLE-3-CARBONITRILE HCL;1-methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrileh...;1-methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrile HCl;2-methyl-5-(methylaminomethyl)pyrazole-3-carbonitrile hydrochloride;Methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrilehydrochloridesalt;1H-Pyrazole-5-carbonitrile, 1-methyl-3-[(methylamino)methyl]-, hydrochloride;1-Methyl-3-[(methylamino)methyl]-1H-pyrazole-5-carbonitrile hydrochloride (1:1);1H-Pyrazole-5-carbonitrile, 1-methyl-3-[(methylamino)methyl]-, hydrochloride (1:1)
CBNumber: CB03054477
Molecular Formula: C7H11ClN4
Formula Weight: 186.64
MOL File: 1643141-20-1.mol

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Ambeed

Product number: A838499
Product name: 1-Methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrilehydrochloride
Purity: 98%
Packaging: 100mg
Price: $15
Updated: 2021/12/16

Ambeed

Product number: A838499
Product name: 1-Methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrilehydrochloride
Purity: 98%
Packaging: 250mg
Price: $25
Updated: 2021/12/16

Chemenu

Product number: CM331110
Product name: 1-Methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrilehydrochloride
Purity: 95%+
Packaging: 100mg
Price: $58
Updated: 2021/12/16

Ambeed

Product number: A838499
Product name: 1-Methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrilehydrochloride
Purity: 98%
Packaging: 1g
Price: $60
Updated: 2021/12/16

Chemenu

Product number: CM331110
Product name: 1-Methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrilehydrochloride
Purity: 95%+
Packaging: 250mg
Price: $93
Updated: 2021/12/16

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1-methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrilehydrochloride Chemical Properties,Usage,Production

Uses

1-Methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrile hydrochloride can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development processes and chemical production processes.

Synthesis

To compound 19 (7.0 kg, 26.1 mol) in DCM (30 L) at O℃ was added triethylamine (5.85 kg, 57.8 mol). The mixture was further cooled to -6°C then trifluoroacetic anhydride (5.85 kg, 27.8 mol) added over 90 minutes [temp kept 0 to 5°C], TLC assay showed the reaction was incomplete. Additional triethylamine (4.1 kg, 40.5 mol) and trifluoroacetic acid (4.1 kg, 19.5 mol) 10 were added over 2 hours until TLC showed complete reaction. The reaction mixture was quenched in to water (40 L) [temp to 23°C], The layers were separated and the aqueous re- extracted with DCM (8 L). The organic layers were sequentially washed with brine (7 L), filtered through a pad of silica (3 kg) and eluted with DCM (10 L). The filtrate was evaporated and chromatographed (9 kg silica, eluent 10-30% EtOAc in hexane). Product fractions were 15 evaporated and azeotroped with IPA to afford compound 20 (6.86 kg, ~94 wt%, 25.8 mol, 99%) as an orange oil. To compound 20 (6.86 kg, ~94 wt%, 25.8 mol) in IPA (35 L) at 17°C was added 37% hydrochloric acid (6.4 L, 77.4 mol). The mixture was heated to 35°C overnight then concentrated 20 to a moist solid and residual water azeotroped with additional IPA (8 L). The resulting moist solid was triturated with MTBE (12 L) at 45°C for 30 minutes then cooled to 20°C and filtered, washing with MTBE (5 L). The solids were dried under vacuum at 45°C to afford compound 21 (4.52 kg, 24.2 mol, 94%) as a white solid. 1H-NMR was consistent with desired product; mp 203-205°C; HPLC 99.3%.

1-methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrilehydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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1-methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrilehydrochloride Suppliers

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View Lastest Price from 1-methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrilehydrochloride manufacturers

Nanjing Fred Technology Co., Ltd

Product: 1-methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrile hydrochloridesalt 1643141-20-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1 ton
Release date: 2023-12-29

Henan Fengda Chemical Co., Ltd

Product: 1-methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrilehydrochloride 1643141-20-1
Price: US $5.00-0.10/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-09

Suzhou Ryan Pharmachem Technology Co.,Ltd.

Product: 1-methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrilehydrochloridesalt 1643141-20-1
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: kg grade
Release date: 2023-05-08

1643141-20-1, 1-methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrilehydrochlorideRelated Search:

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2-methyl-5-(methylaminomethyl)pyrazole-3-carbonitrile hydrochloride

1-Methyl-3-[(methylamino)methyl]-1H-pyrazole-5-carbonitrile hydrochloride (1:1)

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PF06463922 impurity

1643141-20-1