STING agonist-1

Product Name: STING agonist-1
CAS No.: 702662-50-8
Chemical Name: STING agonist-1
Synonyms: STING agonist-1;STING agonist-1 (G10);STING agonist-1, 10 mM in DMSO;G10, STING signaling activator;4-(2-chloro-6-fluorobenzyl)-N-(furan-2-ylmethyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazine-6-carboxamide;4-[(2-Chloro-6-fluorophenyl)methyl]-N-(2-furanylmethyl)-3,4-dihydro-3-oxo-2H-1,4-benzothiazine-6-carboxamide;2H-1,4-Benzothiazine-6-carboxamide, 4-[(2-chloro-6-fluorophenyl)methyl]-N-(2-furanylmethyl)-3,4-dihydro-3-oxo-;inhibit,TMEM173,Inhibitor,STING agonist 1,G 10,G-10,Stimulator of Interferon Genes,STING agonist-1,MITA,MPYS,Virus Protease,ERIS,STING agonist1,STING
CBNumber: CB03067022
Molecular Formula: C21H16ClFN2O3S
Formula Weight: 430.88
MOL File: 702662-50-8.mol

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STING agonist-1 Property

Boiling point:: 668.3±55.0 °C(Predicted)
Density: 1.428±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml; Ethanol: 0.5 mg/ml
form: A crystalline solid
pka: 13.53±0.20(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 22353
Product name: G10
Purity: ≥98%
Packaging: 1mg
Price: $33
Updated: 2024/03/01

Cayman Chemical

Product number: 22353
Product name: G10
Purity: ≥98%
Packaging: 5mg
Price: $107
Updated: 2024/03/01

Cayman Chemical

Product number: 22353
Product name: G10
Purity: ≥98%
Packaging: 10mg
Price: $164
Updated: 2024/03/01

Cayman Chemical

Product number: 22353
Product name: G10
Purity: ≥98%
Packaging: 25mg
Price: $438
Updated: 2021/12/16

TRC

Product number: G932043
Product name: G10
Packaging: 2.5mg
Price: $165
Updated: 2021/12/16

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STING agonist-1 Chemical Properties,Usage,Production

Description

G10 is an indirect activator of stimulator of interferon genes (STING) signaling. It induces transcription of genes dependent on IRF3 and IFN, which are activated by STING, but has no effect on non-STING activated NF-κB-dependent transcription of IL-8, IL-1β, or MIP-1α in human fibroblasts. However, G10 does increase expression of NF-κB-dependent genes in human peripheral blood mononuclear cells (PBMCs) and human umbilical microvascular endothelial cells (HUMECs). In vitro, it prevents replication of the chikungunya and Venezuelan equine encephalitis alphaviruses (IC₉₀s = 8.01 and 24.57 μM, respectively). G10 (100 μM) increases phosphorylation of IRF3, which is lost in cells lacking STING.

Uses

G10 is a novel human-specific STING agonist that elicits antiviral activity against emerging Alphaviruses. G10 potently blocks replication of Alphavirus species Venezuelan Equine Encephalitis Virus (VEEV).

storage

Store at -20°C

STING agonist-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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STING agonist-1 Suppliers

China 53 United Kingdom 1 United States 9 Global 63

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702662-50-8, STING agonist-1Related Search:

STING agonist-1 (G10)

4-[(2-Chloro-6-fluorophenyl)methyl]-N-(2-furanylmethyl)-3,4-dihydro-3-oxo-2H-1,4-benzothiazine-6-carboxamide

STING agonist-1

2H-1,4-Benzothiazine-6-carboxamide, 4-[(2-chloro-6-fluorophenyl)methyl]-N-(2-furanylmethyl)-3,4-dihydro-3-oxo-

4-(2-chloro-6-fluorobenzyl)-N-(furan-2-ylmethyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazine-6-carboxamide

inhibit,TMEM173,Inhibitor,STING agonist 1,G 10,G-10,Stimulator of Interferon Genes,STING agonist-1,MITA,MPYS,Virus Protease,ERIS,STING agonist1,STING

G10, STING signaling activator

STING agonist-1, 10 mM in DMSO

702662-50-8

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