STING agonist-1
- Product Name
- STING agonist-1
- CAS No.
- 702662-50-8
- Chemical Name
- STING agonist-1
- Synonyms
- STING agonist-1;STING agonist-1 (G10);4-(2-chloro-6-fluorobenzyl)-N-(furan-2-ylmethyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazine-6-carboxamide;4-[(2-Chloro-6-fluorophenyl)methyl]-N-(2-furanylmethyl)-3,4-dihydro-3-oxo-2H-1,4-benzothiazine-6-carboxamide;2H-1,4-Benzothiazine-6-carboxamide, 4-[(2-chloro-6-fluorophenyl)methyl]-N-(2-furanylmethyl)-3,4-dihydro-3-oxo-;inhibit,TMEM173,Inhibitor,STING agonist 1,G 10,G-10,Stimulator of Interferon Genes,STING agonist-1,MITA,MPYS,Virus Protease,ERIS,STING agonist1,STING
- CBNumber
- CB03067022
- Molecular Formula
- C21H16ClFN2O3S
- Formula Weight
- 430.88
- MOL File
- 702662-50-8.mol
STING agonist-1 Property
- Boiling point:
- 668.3±55.0 °C(Predicted)
- Density
- 1.428±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml; Ethanol: 0.5 mg/ml
- form
- A crystalline solid
- pka
- 13.53±0.20(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 22353
- Product name
- G10
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $33
- Updated
- 2024/03/01
- Product number
- 22353
- Product name
- G10
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $107
- Updated
- 2024/03/01
- Product number
- 22353
- Product name
- G10
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $164
- Updated
- 2024/03/01
- Product number
- 22353
- Product name
- G10
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $438
- Updated
- 2021/12/16
- Product number
- G932043
- Product name
- G10
- Packaging
- 2.5mg
- Price
- $165
- Updated
- 2021/12/16
STING agonist-1 Chemical Properties,Usage,Production
Description
G10 is an indirect activator of stimulator of interferon genes (STING) signaling. It induces transcription of genes dependent on IRF3 and IFN, which are activated by STING, but has no effect on non-STING activated NF-κB-dependent transcription of IL-8, IL-1β, or MIP-1α in human fibroblasts. However, G10 does increase expression of NF-κB-dependent genes in human peripheral blood mononuclear cells (PBMCs) and human umbilical microvascular endothelial cells (HUMECs). In vitro, it prevents replication of the chikungunya and Venezuelan equine encephalitis alphaviruses (IC90s = 8.01 and 24.57 μM, respectively). G10 (100 μM) increases phosphorylation of IRF3, which is lost in cells lacking STING.
Uses
G10 is a novel human-specific STING agonist that elicits antiviral activity against emerging Alphaviruses. G10 potently blocks replication of Alphavirus species Venezuelan Equine Encephalitis Virus (VEEV).
storage
Store at -20°C