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GSK-F1

Product Name
GSK-F1
CAS No.
1402345-92-9
Chemical Name
GSK-F1
Synonyms
GSK-F1;CS-2666;rac-GSK-F1;PI4KA inhibitor-F1;GSK-F1, 10 mM in DMSO;5-[2-Amino-4-oxo-3-[2-(trifluoromethyl)phenyl]quinazolin-6-yl]-N-(2,4-difluorophenyl)-2-methoxypyridine-3-sulfonamide;5-{2-Amino-4-oxo-3-[2-(trifluoromethyl)phenyl]-3,4-dihydro-6-quinazolinyl}-N-(2,4-difluorophenyl)-2-methoxy-3-pyridinesulfonamide;3-Pyridinesulfonamide, 5-[2-amino-3,4-dihydro-4-oxo-3-[2-(trifluoromethyl)phenyl]-6-quinazolinyl]-N-(2,4-difluorophenyl)-2-methoxy-;hepatitis C virus,Phosphoinositide 3-kinase,Inhibitor,HEK293-AT1 cells,GSK-F-1,PI4K,Phosphatidylinositol 4 kinases,GSK-F1,HCV,GSKF1,COS-7,inhibit,GSK F1,PI4 kinases,PI3K
CBNumber
CB03067552
Molecular Formula
C27H18F5N5O4S
Formula Weight
603.52
MOL File
1402345-92-9.mol
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GSK-F1 Property

Boiling point:
744.3±70.0 °C(Predicted)
Density 
1.55±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C, sealed storage, away from moisture and light
solubility 
DMSO : 125 mg/mL (207.12 mM; Need ultrasonic)
form 
Solid
pka
5.66±0.50(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Adipogen Life Sciences
Product number
SYN-1220-M005
Product name
GSK-F1
Purity
≥95%
Packaging
5mg
Price
$270
Updated
2021/12/16
Adipogen Life Sciences
Product number
SYN-1220-M010
Product name
GSK-F1
Purity
≥95%
Packaging
10mg
Price
$421
Updated
2021/12/16
DC Chemicals
Product number
DC10064
Product name
GSK-F1
Purity
>98%
Packaging
10mg
Price
$300
Updated
2021/12/16
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GSK-F1 Chemical Properties,Usage,Production

Uses

GSK-F1 (Compound F1) is an orally active PI4KA inhibitor with pIC50 values of 8.0, 5.9, 5.8, 5.9, 5.9 and 6.4 against PI4KA, PI4KB, PI3KA, PI3KB, PI3KG and PI3KD, respectively. GSK-F1 can be used for HCV infection research[1].

IC 50

PI4KA: 8.0 (pIC50); PI3KD: 6.4 (pIC50); PI4KB: 5.9 (pIC50); PI3KB: 5.9 (pIC50); PI3KG: 5.9 (pIC50); PI3KA: 5.8 (pIC50)

References

[1] Bojjireddy N, et al. Pharmacological and genetic targeting of the PI4KA enzyme reveals its important role in maintaining plasma membrane phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate levels. J Biol Chem. 2014 Feb 28;289(9):6120-32. DOI:10.1074/jbc.M113.531426

GSK-F1 Preparation Products And Raw materials

Raw materials

Preparation Products

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GSK-F1 Suppliers

China 30 United Kingdom 1 United States 3 Global 34
Novachemistry
Tel
44-20819178-90 02081917890
Fax
(0)2080432064
Email
info@novachemistry.com
Country
United Kingdom
ProdList
4381
Advantage
58

1402345-92-9, GSK-F1Related Search:


  • GSK-F1
  • rac-GSK-F1
  • CS-2666
  • PI4KA inhibitor-F1
  • 3-Pyridinesulfonamide, 5-[2-amino-3,4-dihydro-4-oxo-3-[2-(trifluoromethyl)phenyl]-6-quinazolinyl]-N-(2,4-difluorophenyl)-2-methoxy-
  • 5-{2-Amino-4-oxo-3-[2-(trifluoromethyl)phenyl]-3,4-dihydro-6-quinazolinyl}-N-(2,4-difluorophenyl)-2-methoxy-3-pyridinesulfonamide
  • hepatitis C virus,Phosphoinositide 3-kinase,Inhibitor,HEK293-AT1 cells,GSK-F-1,PI4K,Phosphatidylinositol 4 kinases,GSK-F1,HCV,GSKF1,COS-7,inhibit,GSK F1,PI4 kinases,PI3K
  • GSK-F1, 10 mM in DMSO
  • 5-[2-Amino-4-oxo-3-[2-(trifluoromethyl)phenyl]quinazolin-6-yl]-N-(2,4-difluorophenyl)-2-methoxypyridine-3-sulfonamide
  • 1402345-92-9
  • C27H18F5N5O4S