ChemicalBook > CAS DataBase List > Sacubitril Sodium

Sacubitril Sodium

Product Name: Sacubitril Sodium
CAS No.: 149690-05-1
Chemical Name: Sacubitril Sodium
Synonyms: Sacubitril sodium;Valsartan Sodium;Thacubatra sodium;AHU-377 sodium salt;Sacubitril Sodium Salt;AHU-377 (Sacubitril free base);Saccubitril Valsartan Sodium Impurity A-1;Sodium,4-[[(2S,4R)-5-ethoxy-4-methyl-5-oxo-1-(4-phenylphenyl)pentan-2-yl]amino]-4-oxobutanoate;sodium 4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate;(αR,γS)- γ-[(3-Carboxy -1-oxopropyl) amino]-methyl-[1,1'-biphenyl]-4-pentanoic acid 4-ethyl ester sodium salt
CBNumber: CB03069990
Molecular Formula: C24H28NNaO5
Formula Weight: 433.47259
MOL File: 149690-05-1.mol

Less

Sacubitril Sodium Property

Melting point:: 163-165°C
storage temp.: -20°C, Hygroscopic
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
color: White to Off-White
Stability:: Hygroscopic
InChIKey: RRTBVEJIZWGATF-OIRVNKSWNA-M
SMILES: [Na+].C([O-])(=O)CCC(N[C@@H](C[C@@H](C)C(OCC)=O)CC1=CC=C(C2=CC=CC=C2)C=C1)=O |&1:8,10,r|

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H319Causes serious eye irritation

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

DC Chemicals

Product number: DC32235
Product name: Sacubitrilsodium
Packaging: 250mg
Price: $700
Updated: 2021/12/16

DC Chemicals

Product number: DC32235
Product name: Sacubitrilsodium
Packaging: 1g
Price: $1400
Updated: 2021/12/16

Less

Sacubitril Sodium Chemical Properties,Usage,Production

Description

Sacubitril Sodium is a potent orally active NEP (enkephalinase) inhibitor with an IC50 of 5 nM. Sacubitril Sodium enhances the tone of the natriuretic peptide (NP) system and exerts significant antihypertensive effects. Sacubitril Sodium is a component of the heart failure drug LCZ696. Sacubitril Sodium is used in heart failure, hypertension and COVID-19 studies.

Uses

Sacubitril Sodium Salt is a salt of Sacubitril, an antihypertensive drug used in combination with valsartan. The combination drug, valsartan/sacubitril, known during trials as LCZ696 and marketed under the brand name, Entresto, is a treatment for heart failure.

in vivo

In normotensive rats, pretreatment with Sacubitril sodium (3, 10 and 30 mg/kg, PO.) augments ANP-evoked plasma cGMP levels by 2.4, 3.3 and 4.0 fold, respectively (4h AUC compared to vehicle)^[1].
Sacubitril sodium (30 and 100 mg/kg, PO) produces a dose-dependent antihypertensive effect in Dahl-SS rats^[1].

Sacubitril Sodium Preparation Products And Raw materials

Raw materials

Preparation Products

Less

Sacubitril Sodium Suppliers

China 89 India 11 United States 5 Global 105

CHANGZHOU PHARMACEUTICAL FACTORY

Tel: 519-88821493 18915891730
Email: shm@czpharma.com
Country: China
ProdList: 170
Advantage: 58

Hubei Chenxin Pharmaceutical Co., Ltd.

Tel: 18696113233
Fax: QQ:2544920688
Email: like1076463918@163.com
Country: China
ProdList: 3130
Advantage: 58

Shanghai Haozhixiang Biotechnology Co., Ltd

Tel: 526763801 13301653310
Fax: +86-21-51619052
Email: 526763801@qq.com
Country: China
ProdList: 9274
Advantage: 55

Wuhan DKY Technology Co.,Ltd.

Tel: 027-27-81302488 15972195220
Fax: 027-81302088
Email: info@dkybpc.com
Country: China
ProdList: 1758
Advantage: 58

Shanghai Pansopharm Technology Co., Ltd.

Tel: 021-20962833 15316628753
Fax: 021-2096-2832
Email: sales@pansopharm.com
Country: China
ProdList: 724
Advantage: 60

INTERCHEMIE NANJING PHARMATECH CO., LTD

Tel: 13656237714 13656237714;
Fax: 0512-65852853
Email: xiaokunfu@kyyykj.com
Country: China
ProdList: 295
Advantage: 55

Shanghai QianYan Bio-technology Co., Ltd

Tel: 02781293128
Email: orders@biochemsafebuy.com
Country: China
ProdList: 9923
Advantage: 55

Cangzhou Enke Pharma-tech Co., Ltd.

Tel: 0317-5296180 15533709196
Fax: 0317-5106596
Email: sale@enkepharma.com
Country: China
ProdList: 2267
Advantage: 55

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
Advantage: 62

Hubei widely chemical technology Co., Ltd.

Tel: 027-59402396 13419635609
Fax: 027-83989310
Email: 13419635609@163.com
Country: China
ProdList: 1987
Advantage: 55

Wuhan Wsem Biological Co., Ltd.

Tel: 027-83778876 13667159345
Fax: 027-83778876
Email: 13667159345@163.com
Country: China
ProdList: 1997
Advantage: 55

Wellman Pharmaceutical Group Limited

Tel: 027-027-83778875 15807197853
Fax: 027-83991220
Email: 15807197853@163.com
Country: China
ProdList: 3931
Advantage: 58

Hubei widely chemical technology Co., Ltd.

Tel: 027-83778895 18602735115
Fax: 027-51119224
Email: 18602735115@163.com
Country: China
ProdList: 2005
Advantage: 64

Jinan Yaoyan Pharmaceutical Co., Ltd.

Tel
Fax: -
Email: jnyaoyan@163.com
Country: China
ProdList: 3069
Advantage: 58

Nanjing Meihao Pharmaceutical Technology Co., Ltd.

Tel: meitaochem@126.com
Email: meitaochem@126.com
Country: China
ProdList: 19103
Advantage: 58

ShanDong Look Chemical Co.,Ltd.

Tel: +8617653113219
Email: sales01@sdlookchemical.com
Country: China
ProdList: 2768
Advantage: 58

Zhejiang J&C Biological Technology Co.,Limited

Tel: +1-2135480471
Email: sales@sarms4muscle.com
Country: China
ProdList: 10473
Advantage: 58

Hefei TNJ Chemical Industry Co.,Ltd.

Tel: +86-0551-65418684 +8618949823763
Fax: 0086-551-65418684
Email: sales@tnjchem.com
Country: China
ProdList: 25356
Advantage: 58

AFINE CHEMICALS LIMITED

Tel: +86-0571-85134551
Fax: 008657185134895
Email: sales@afinechem.com
Country: China
ProdList: 15109
Advantage: 58

Shandong Sihuan Pharmaceutical Co., Ltd.

Tel: 0531-88993893 13335127975
Fax: QQ:787658403
Email: fairouz@sdsihuanpharm.com
Country: China
ProdList: 82
Advantage: 58

Shanghai Yanze Chemical Co., Ltd.

Tel: 021-021-13773155751 19975051755
Email: 260924549@qq.com
Country: China
ProdList: 10524
Advantage: 58

Wuhan Dingtong Pharmaceutical Co., Ltd

Tel: 027-027-59207795 18327179646
Fax: 027-59207795
Email: 18327179646@163.com
Country: China
ProdList: 1986
Advantage: 58

Nanjing Becas pharmatech Ltd.

Tel: 13912903754
Email: info@becaspharma.com
Country: China
ProdList: 2763
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: 029-029-81024372 17792795018
Fax: 029-88380327
Email: 1027@dideu.com
Country: China
ProdList: 10003
Advantage: 58

Shandong WorldSun Biological Technology Co., Ltd.

Tel: 0531-88723173 18596073690
Email: 1047208234@qq.com
Country: China
ProdList: 6776
Advantage: 58

Shanghai Botuo Biotechnology Co., LTD

Tel: 16621358918
Fax: QQ:402135374
Email: botuopharma888@163.com
Country: China
ProdList: 9208
Advantage: 58

Wuhan Wiseman Bioengineering Co.,Ltd

Tel: 13419526507 13419526507
Fax: 027-59506022
Email: 13419526507@163.com
Country: China
ProdList: 2845
Advantage: 58

Hubei Zhongshan Medical Technology Co., Ltd

Tel: 027-61907345 13397111514
Fax: 3443707954
Email: w13397111514@163.com
Country: China
ProdList: 1005
Advantage: 58

Wuhan Yuqing Jiaheng Pharmaceutical Co., Ltd

Tel: 027-83855310 13476018176
Fax: 13476018176
Email: 408614617@qq.com
Country: China
ProdList: 996
Advantage: 58

Guangzhou Juntang Technology Co., Ltd

Tel: 020-36607679 13502246435
Email: sales@dmstandards.com
Country: China
ProdList: 10945
Advantage: 58

Manhag Testing Technology Co., Ltd

Tel: 020-3846 2365 19110442770
Email: 458677837@qq.com
Country: China
ProdList: 7775
Advantage: 58

Jinan Dexinjia Bio&Tech Co., Ltd

Tel: 0531-82371986 15269101859
Fax: 0531-82375893
Email: 3276840968@qq.com
Country: China
ProdList: 1604
Advantage: 58

Jiangxi ravel Biotechnology Co.,Ltd

Tel: 400-880-2824; 13184580281
Fax: 400-880-2824
Email: hj@ruiweier.cn
Country: China
ProdList: 2686
Advantage: 58

Jiangxi ravel Biotechnology Co.,Ltd

Tel: 18502762009
Email: 721846333@qq.com
Country: China
ProdList: 2172
Advantage: 58

Hubei wei shi reagent group ltd., company

Tel: 027-59102966 18717199209
Fax: 027-59379337
Email: 2853877583@qq.com
Country: China
ProdList: 2715
Advantage: 58

Hubei Chenxin Pharmaceutical Co., Ltd.

Tel: 17362916295 17362916295;
Fax: QQ:840947394
Email: w17362916295@163.com
Country: China
ProdList: 3004
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 59936
Advantage: 58

Jiangxi ravel Biotechnology Co.,Ltd

Tel: 400-880-2824 15608648206
Email: 1987516016@qq.com
Country: China
ProdList: 2671
Advantage: 58

Jiangxi ravel Biotechnology Co.,Ltd

Tel: 185-0276-2003 18502762003;
Email: 435918333@qq.com
Country: China
ProdList: 2213
Advantage: 58

Hubei Weideli Chemical Reagent Co.，Ltd.

Tel: 133-3998-5473 13339985473
Email: C13339985473@163.com
Country: China
ProdList: 4991
Advantage: 58

Hubei Weideli Chemical Reagent Co.，Ltd.

Tel: 027-59222918; 13385289472
Email: Z13385289472@163.com
Country: China
ProdList: 4766
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

Hubei wei shi reagent group ltd., company

Tel: 027-59105166; 13125137732
Email: 2853863890@qq.com
Country: China
ProdList: 2987
Advantage: 58

HUBEI HICKS BIOCHEMICAL CO.,LTD

Tel: 18696113233
Email: 15927219311@163.com
Country: China
ProdList: 1660
Advantage: 58

LGC Science (Shanghai) Ltd.

Tel: 17717235263
Email: cindy.yang@lgcgroup.com
Country: China
ProdList: 18003
Advantage: 58

Noah Thiel Pharmaceutical Technology (Shanghai) Co. , Ltd.

Tel: 4008215138 15216673995
Email: 1449790521@qq.com
Country: China
ProdList: 75
Advantage: 58

Hubei Hicks Biochemical Co., Ltd

Tel: 17362916295; 17362916295
Email: w17362916295@163.com
Country: China
ProdList: 3992
Advantage: 58

Shanghai Beiwanta Biotechnology Co., Ltd.

Tel: 021-67187366 19901745723
Email: info@bwtlab.com
Country: China
ProdList: 9650
Advantage: 58

https://hanhongsci.com/

Tel: 021-54306202 18917919676
Email: info@hanhongsci.com
Country: China
ProdList: 29995
Advantage: 58

shanghai yayu biomedical co.,ltd

Tel: 021-54370211 18051886391
Email: 3007215920@qq.com
Country: China
ProdList: 2989
Advantage: 58

Less

View Lastest Price from Sacubitril Sodium manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: Sacubitril sodium 149690-05-1
Price: US $2.00-5.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-19

Watson Biotechnology Co.,Ltd

Product: Sacubitril Sodium 149690-05-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20MT
Release date: 2025-01-09

Shaanxi Dideu New Materials Co. Ltd

Product: Sacubitril Sodium 149690-05-1
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-02-22

149690-05-1, Sacubitril Sodium Related Search:

LCZ696(valsartan + sacubitril) impurity 35 [1,1′-Biphenyl]-4-pentanoic acid, γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl-, 4-methyl ester, calcium salt (2:1), (αR,γS)- LCZ696(valsartan + sacubitril) impurity 31 [1,1'-Biphenyl]-4-pentanoic acid, γ-(acetylamino)-α-methyl-, (αR,γS)- LCZ696(valsartan + sacubitril) impurity 34 2S,4R-Sacubitril Sacubatrava valsartan sodium hydrate Sacubitril Impurity 43 Sacubitril Methyl esterQ: What is Sacubitril Methyl ester Q: What is the CAS Number of Sacubitril Methyl ester Sacubitrilat-d5

Sacubitril Sodium Salt

Sacubitril sodium

Valsartan Sodium

sodium 4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate

AHU-377 (Sacubitril free base)

AHU-377 sodium salt

Sodium,4-[[(2S,4R)-5-ethoxy-4-methyl-5-oxo-1-(4-phenylphenyl)pentan-2-yl]amino]-4-oxobutanoate

Thacubatra sodium

(αR,γS)- γ-[(3-Carboxy -1-oxopropyl) amino]-methyl-[1,1'-biphenyl]-4-pentanoic acid 4-ethyl ester sodium salt

Sacubitril Sodium: Sodium 4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate

(αR,γS)- γ-[(3-Carboxy -1-oxopropyl) amino]-methyl-[1,1'-biphenyl]-4-pentanoic acid 4-ethyl ester sodium salt (Intermediate of Sacubitril Valsartan Sodium)

Saccubitril Valsartan Sodium Impurity A-1

149690-05-1