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Sacubitril Sodium

Product Name
Sacubitril Sodium
CAS No.
149690-05-1
Chemical Name
Sacubitril Sodium
Synonyms
Sacubitril sodium;Valsartan Sodium;Thacubatra sodium;AHU-377 sodium salt;Sacubitril Sodium Salt;AHU-377 (Sacubitril free base);Sodium,4-[[(2S,4R)-5-ethoxy-4-methyl-5-oxo-1-(4-phenylphenyl)pentan-2-yl]amino]-4-oxobutanoate;sodium 4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate;Sodium 4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate;(αR,γS)- γ-[(3-Carboxy -1-oxopropyl) amino]-methyl-[1,1'-biphenyl]-4-pentanoic acid 4-ethyl ester sodium salt
CBNumber
CB03069990
Molecular Formula
C24H28NNaO5
Formula Weight
433.47259
MOL File
149690-05-1.mol
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Sacubitril Sodium Property

Melting point:
163-165°C
storage temp. 
-20°C, Hygroscopic
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
color 
White to Off-White
Stability:
Hygroscopic
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

DC Chemicals
Product number
DC32235
Product name
Sacubitrilsodium
Packaging
250mg
Price
$700
Updated
2021/12/16
DC Chemicals
Product number
DC32235
Product name
Sacubitrilsodium
Packaging
1g
Price
$1400
Updated
2021/12/16
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Sacubitril Sodium Chemical Properties,Usage,Production

Description

Sacubitril Sodium is a potent orally active NEP (enkephalinase) inhibitor with an IC50 of 5 nM. Sacubitril Sodium enhances the tone of the natriuretic peptide (NP) system and exerts significant antihypertensive effects. Sacubitril Sodium is a component of the heart failure drug LCZ696. Sacubitril Sodium is used in heart failure, hypertension and COVID-19 studies.

Uses

Sacubitril Sodium Salt is a salt of Sacubitril, an antihypertensive drug used in combination with valsartan. The combination drug, valsartan/sacubitril, known during trials as LCZ696 and marketed under the brand name, Entresto, is a treatment for heart failure.

Sacubitril Sodium Preparation Products And Raw materials

Raw materials

Preparation Products

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Sacubitril Sodium Suppliers

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View Lastest Price from Sacubitril Sodium manufacturers

Apeloa production Co.,Limited
Product
Sacubitril sodium 149690-05-1
Price
US $1.00/g
Min. Order
1g
Purity
98%
Supply Ability
1000
Release date
2024-05-22

149690-05-1, Sacubitril Sodium Related Search:

LCZ696(valsartan + sacubitril) impurity 35 [1,1′-Biphenyl]-4-pentanoic acid, γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl-, 4-methyl ester, calcium salt (2:1), (αR,γS)- LCZ696(valsartan + sacubitril) impurity 31 [1,1'-Biphenyl]-4-pentanoic acid, γ-(acetylamino)-α-methyl-, (αR,γS)- LCZ696(valsartan + sacubitril) impurity 34 2S,4R-Sacubitril Sacubatrava valsartan sodium hydrate Sacubitril Impurity 43 Sacubitril Methyl esterQ: What is Sacubitril Methyl ester Q: What is the CAS Number of Sacubitril Methyl ester Sacubitrilat-d5

  • Sacubitril Sodium Salt
  • Sacubitril sodium
  • Valsartan Sodium
  • sodium 4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate
  • AHU-377 (Sacubitril free base)
  • AHU-377 sodium salt
  • Sodium,4-[[(2S,4R)-5-ethoxy-4-methyl-5-oxo-1-(4-phenylphenyl)pentan-2-yl]amino]-4-oxobutanoate
  • Thacubatra sodium
  • (αR,γS)- γ-[(3-Carboxy -1-oxopropyl) amino]-methyl-[1,1'-biphenyl]-4-pentanoic acid 4-ethyl ester sodium salt
  • Sodium 4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate
  • 149690-05-1