DESMOSTEROL
- Product Name
- DESMOSTEROL
- CAS No.
- 313-04-2
- Chemical Name
- DESMOSTEROL
- Synonyms
- Desmostero;esmosterol;DESMOSTEROL;24-DEHYDROCHOLESTEROL;Cholesterol impurity B;desmosterol crystalline;Cholesta-5,24-dien-3-ol;5,24-Cholestadien-3β-ol;Cholesterol Impurity 12;5, 24-CHOLESTADIEN-3β-OL
- CBNumber
- CB0307682
- Molecular Formula
- C27H44O
- Formula Weight
- 384.65
- MOL File
- 313-04-2.mol
DESMOSTEROL Property
- Melting point:
- 121.5°, also reported as 119-119.5°
- alpha
- D27 -41.0° (c = 1 in chloroform)
- Boiling point:
- 483.2±14.0 °C(Predicted)
- Density
- 1.00±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 15.03±0.70(Predicted)
- color
- Wihte to Off-White
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- D6513
- Product name
- Desmosterol
- Purity
- ≥84% (GC)
- Packaging
- 5mg
- Price
- $86
- Updated
- 2024/03/01
- Product number
- D6513
- Product name
- Desmosterol
- Purity
- ≥84% (GC)
- Packaging
- 10mg
- Price
- $149
- Updated
- 2024/03/01
- Product number
- 14943
- Product name
- 24-dehydro Cholesterol
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $36
- Updated
- 2024/03/01
- Product number
- 14943
- Product name
- 24-dehydro Cholesterol
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $70
- Updated
- 2024/03/01
- Product number
- 14943
- Product name
- 24-dehydro Cholesterol
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $120
- Updated
- 2024/03/01
DESMOSTEROL Chemical Properties,Usage,Production
Chemical Properties
Off-White Solid
Uses
24-dehydro Cholesterol is an immediate precursor to cholesterol in the Bloch pathway of cholesterol biosynthesis. Structurally, it varies from cholesterol only by a single double bond at carbon 24 and has been used as cholesterol substitute in cellular membrane studies. During brain development, 24-dehydro cholesterol transiently accumulates, composing up to 30% of total brain sterol, where it is poised to rapidly enrich membrane sterols. However, defects in cholesterol synthesis can lead to a condition called, desmosterolosis, which results in an accumulation of excess 24-dehydro cholesterol. 24-dehydro Cholesterol has been reported to activate liver X receptor-target genes in both the liver of cholesterol-free mice and in cholesterol-starved macrophage foam cells in atherosclerotic lesions.[Cayman Chemical]
Uses
Desmosterol has been used as a sterol to test its interaction with human protein Mincle and as an internal standard in ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). It may be used as in the preparation of lipid monolayers.
Uses
A metabolite of Cholesterol (C432501).
Definition
ChEBI: A cholestanoid that is cholesta-5,24-diene substituted by a beta-hydroxy group at position 3. It is an intermediate metabolite obtained during the synthesis of cholesterol.
General Description
Desmosterol lacks a double bond between C24 and C25 compared to cholesterol. It is present in the membrane of spermatozoa and astrocytes and is the major brain sterol.
Biochem/physiol Actions
Desmosterol is a precursor of cholesterol in the Bloch pathway and the enzyme 24-dehydrocholesterol reductase catalyzes this step. Desmosterol accumulates during impairment of 24-dehydrocholesterol reductase enzyme thereby leading to desmosterolosis. Desmosterol is a liver X receptor (LXR) agonist . It is a potential therapeutic target for treating the neurodegenerative disorder. Desmosterol regulates inflammatory signaling in macrophages.
DESMOSTEROL Preparation Products And Raw materials
Raw materials
Preparation Products
DESMOSTEROL Suppliers
View Lastest Price from DESMOSTEROL manufacturers
- Product
- Desmosterol 313-04-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-19