ChemicalBook > CAS DataBase List > Deferiprone

Deferiprone

Product Name
Deferiprone
CAS No.
30652-11-0
Chemical Name
Deferiprone
Synonyms
L1;CP20;DMHP;Kelfer;Deferrone;DEFERIPRON;DEFERIDONE;eferiprone;DEFERIPRONE;Deferiprone CRS
CBNumber
CB0308124
Molecular Formula
C7H9NO2
Formula Weight
139.15
MOL File
30652-11-0.mol
More
Less

Deferiprone Property

Melting point:
272-275 °C (lit.)
Boiling point:
255.1°C (rough estimate)
Density 
1.1997 (rough estimate)
refractive index 
1.4800 (estimate)
storage temp. 
2-8°C
solubility 
Soluble in Water (up to 5 mg/ml with warming).
form 
Crystalline Powder or Needles
pka
pKa1 3.3, pKa2 9.7(at 25℃)
color 
White to off-white
Water Solubility 
Soluble in hot water
Merck 
14,2859
Stability:
Stable for 1 year from date of purchase as supplied. Solutions are not stable and must be prepared fresh daily.
InChI
InChI=1S/C7H9NO2/c1-5-7(10)6(9)3-4-8(5)2/h3-4,10H,1-2H3
InChIKey
TZXKOCQBRNJULO-UHFFFAOYSA-N
SMILES
C1(C)N(C)C=CC(=O)C=1O
CAS DataBase Reference
30652-11-0(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
26-36-37/39
WGK Germany 
3
RTECS 
UU7785940
HS Code 
29333990
Hazardous Substances Data
30652-11-0(Hazardous Substances Data)
Toxicity
LD50 i.p. in rats, mice: 650 mg/kg, 0.8-1.0 g/kg; i.g. in rats: 2.0-3.0 g/kg (Kontoghiorghes, 1995)
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
379409
Product name
3-Hydroxy-1,2-dimethyl-4(1H)-pyridone
Purity
98%
Packaging
5g
Price
$76.8
Updated
2024/03/01
Sigma-Aldrich
Product number
379409
Product name
3-Hydroxy-1,2-dimethyl-4(1H)-pyridone
Purity
98%
Packaging
25g
Price
$233
Updated
2024/03/01
TCI Chemical
Product number
H0944
Product name
3-Hydroxy-1,2-dimethyl-4(1H)-pyridone
Purity
>98.0%(T)
Packaging
5g
Price
$80
Updated
2024/03/01
TCI Chemical
Product number
H0944
Product name
3-Hydroxy-1,2-dimethyl-4(1H)-pyridone
Purity
>98.0%(T)
Packaging
25g
Price
$230
Updated
2024/03/01
Cayman Chemical
Product number
20387
Product name
Deferiprone
Purity
≥95%
Packaging
1g
Price
$32
Updated
2024/03/01
More
Less

Deferiprone Chemical Properties,Usage,Production

Description

Deferiprone is a lipophilic iron chelator that binds to iron at a molar ratio of 3:1 (ligand: iron). Its active form is available orally, making it the only oral iron chelator. Deferiprone is a member of the 4-pyridone family and is a pyridine 4-4 (1H) -one, with a methyl substitution at positions 1 and 2 and a hydroxyl substitution at position 3. By binding to iron, Deferiprone can remove excess iron from the body and prevent serum iron overload in patients with transfusion-dependent thalassemia. It has chelation and protective effects and is primarily used to treat thalassaemia.

Chemical Properties

White Needles

Originator

Cipla (India)

Uses

3-Hydroxy-1,2-dimethyl-4(1H)-pyridone (OH-pyridone) may be used in the bacterial killing assays. It has been employed as hydroxyketone chelating agent and its cytotoxic action against oral human normal and tumor cell lines has been evaluated.

Uses

A chelator that could replace disferrioxamine. It is orally and parenterally effective in the removal of iron in vivo from rabbits and mice and also from transferrin and ferritin in vitro

Definition

ChEBI: Deferiprone is a member of the class of 4-pyridones that is pyridin-4(1H)-one substituted at positions 1 and 2 by methyl groups and at position 3 by a hydroxy group. A lipid-soluble iron-chelator used for treatment of thalassaemia. It has a role as an iron chelator and a protective agent.

brand name

Kelfer

General Description

3-Hydroxy-1,2-dimethyl-4(1H)-pyridone (Hdpp, Deferiprone) is a hydroxy ketone derivative. It reacts with uranyl salts [UO2(NO3)2] in aqueous acidic solution to afford mono nuclear complexes ([UO2(dpp)(Hdpp)2(H2O)]ClO4). X-ray studies have been conducted to examine the structure and geometry of these complexes.

Clinical Use

Orally administered chelator:
Treatment of transfusional iron overload

Metabolism

Deferiprone is hepatically metabolised to an inactive glucuronide metabolite and is excreted mainly in the urine as the metabolite and the iron-deferiprone complex, with a small amount of unchanged drug.

References

1) Hider and Hoffbrand (2018),?The Role of Deferiprone in Iron Chelation; N. Engl. J. Med.,?379?2140 2) Sripetchwandee?et al.?(2016),?A combination of an iron chelator with an antioxidant effectively diminishes the dendritic loss, tau-hyperphosphorylation, amyloid-β accumulation and brain mitochondrial dynamic disruption in rats with chronic iron-overload., Neuroscience?332?191 3) Liu?et al.?(2018),?Iron and Alzheimer’s Disease: From Pathogenesis to Therapeutic Implications;?Front. Neurosci,?12?632

Deferiprone Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Deferiprone Suppliers

Americas 1 Belgium 2 Canada 4 China 219 Colombia 1 Europe 4 France 1 Germany 4 India 43 Israel 1 Japan 3 Nepal 1 Nigeria 1 Slovakia 1 South Korea 1 Switzerland 2 The Netherlands 2 Ukraine 1 United Arab Emirates 1 United Kingdom 10 United States 34 Global 337
Henan Research New Material Co., Ltd.
Tel
1890-3931531 18903931628
Email
sales036@researchvip.com
Country
China
ProdList
181
Advantage
58
Taizhou Creating Bio-pharm Co.,Ltd.
Tel
+86-0576-88827176 +86-18906581668
Email
post@creatingchemical.com
Country
China
ProdList
229
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
Advantage
61
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14103
Advantage
59
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11655
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12984
Advantage
57
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4727
Advantage
58
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17770
Advantage
75
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12335
Advantage
58
Beijing innoChem Science & Technology Co.,Ltd.
Tel
400-810-7969 010-59572699
Fax
010-59572688
Email
ningzi.li@inno-chem.com.cn
Country
China
ProdList
6134
Advantage
55
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9891
Advantage
58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66099280 17798518460
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
19915
Advantage
55
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
22514
Advantage
55
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 18021050169
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
Shanghai Witofly Chemical Co.,Ltd
Tel
Email
sales@witofly.com
Country
China
ProdList
2864
Advantage
52
Zouping Mingxing Chemical Co.,Ltd.
Tel
86-13605431940 13605431940
Fax
0086-0543-2240079
Email
zpmxchemical@126.com
Country
China
ProdList
1482
Advantage
62
TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7783
Advantage
58
Shanghai BeiZhuo Biotech Co., Ltd.
Tel
021-61119791,13386096464
Fax
021-50190009
Email
bzswkf@foxmail.com
Country
China
ProdList
3921
Advantage
50
Hubei XinyuanShun Chemical Co., Ltd.
Tel
13971561712, 13995564702, 027-50664929
Fax
027-50664927
Email
hbeixys2001@163.com
Country
China
ProdList
3120
Advantage
55
Shanghai JONLN Reagent Co., Ltd.
Tel
400-0066400 13621662912
Fax
021-55660885
Email
422131432@qq.com
Country
China
ProdList
9978
Advantage
55
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
41462
Advantage
60
Shanghai DiBai Chemicals Co., Ltd.
Tel
021-54359730 400-008-9730
Fax
021-54353864
Email
info@chemxyz.com
Country
China
ProdList
3991
Advantage
60
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
18097
Advantage
56
Taizhou Creating Chemical Co., Ltd
Tel
0576-88827176 18906581668
Fax
86- 576 88822496
Email
sonya@creatingchemical.com
Country
China
ProdList
130
Advantage
64
Shanghai Macklin Biochemical Co.,Ltd.
Tel
15221275939 15221275939
Fax
021-50706099
Email
shenlinxing@macklin.cn
Country
China
ProdList
16166
Advantage
55
Shanghai Yongye Biotechnology Co., Ltd.
Tel
86-021-61559134 15921386130
Fax
021-55068248
Email
3423497944@qq.com
Country
China
ProdList
8144
Advantage
55
Hubei Jusheng Technology Co.,Ltd
Tel
027-59599241 18871490274
Fax
027-59599241
Email
1400878000@qq.com
Country
China
ProdList
9958
Advantage
58
Chizhou Kailong Import and Export Trade Co., Ltd.
Tel
Fax
-
Email
xg01_gj@163.com
Country
China
ProdList
9484
Advantage
50
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51456
Advantage
80
Zhengzhou Alfachem Co., Ltd.
Tel
0371-53765687 18937137882
Fax
QQ:2885373884
Email
2853979813@qq.com
Country
China
ProdList
7888
Advantage
55
Codow Chemical Co.,Ltd.
Tel
18620099427
Fax
+86-20-62619665
Email
amy@howeipharm.com
Country
China
ProdList
17687
Advantage
55
Henan CoreyChem Co., Ltd
Tel
0371-86658258
Fax
0371-60996044
Email
info@coreychem.com
Country
China
ProdList
10453
Advantage
58
Shanghai Qiao Chemical Science Co., Ltd
Tel
021-58892003
Email
info@qiaochem.com
Country
China
ProdList
5904
Advantage
65
Guangzhou QiYun Biotechnology Co., Ltd.
Tel
020-61288194 61288195
Fax
020-61288700
Email
505721671@qq.com
Country
China
ProdList
3866
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
27313
Advantage
60
Shanghai QianYan Bio-technology Co., Ltd
Tel
02781293128
Email
orders@biochemsafebuy.com
Country
China
ProdList
9923
Advantage
55
Shanghai Changyan Chem & Tech Co., Ltd.
Tel
021-20242659 18930833303
Fax
+86 (21) 2024-2659
Email
Sales@changyanchem.cn
Country
China
ProdList
5010
Advantage
55
Raw material medicin reagent co.,Ltd
Tel
Email
sales@njromanme.com
Country
China
ProdList
4529
Advantage
58
Chengdu Dianchun Technology Co., Ltd
Tel
400-1166-196 18502815961
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
14603
Advantage
60
Shanghai ChengShao Biological Technology Co., Ltd.
Tel
021-61847300 13341622919
Fax
021-61847300
Email
shcss01@163.com
Country
China
ProdList
4808
Advantage
58
Shanghai SuperLan Chemcial Technique Centre
Tel
021-2022843681 15618226720
Fax
+86-21-51601218
Email
lucy@atkchemical.com
Country
China
ProdList
9987
Advantage
58
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 4009686088
Email
3193328036@qq.com
Country
China
ProdList
29764
Advantage
68
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
More
Less

View Lastest Price from Deferiprone manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
Deferiprone 30652-11-0
Price
US $100.00/KG
Min. Order
1KG
Purity
99%min
Supply Ability
20 TON
Release date
2024-10-31
Henan Research New Materials Co., Ltd.
Product
3-Hydroxy-1,2-dimethyl-4(1H)-pyridone 30652-11-0
Price
US $0.00-0.00/Kg
Min. Order
1Kg
Purity
99%
Supply Ability
1000kg
Release date
2024-07-22
shandong perfect biotechnology co.ltd
Product
Deferiprone 30652-11-0
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98% HPLC
Supply Ability
5 ton
Release date
2023-07-04

30652-11-0, DeferiproneRelated Search:

Deferiprone 4-HYDROXYPYRIDINE 3-Hydroxypyridine 1-BENZYL-3-[(2,6-DICHLOROBENZYL)OXY]-2-METHYL-4(1H)-PYRIDINONE 1-(2-CHLORO-6-FLUOROBENZYL)-3-[(2,6-DICHLOROBENZYL)OXY]-2-METHYL-4(1H)-PYRIDINONE 3-[(2-CHLORO-6-FLUOROBENZYL)OXY]-1-(4-FLUOROBENZYL)-2-METHYL-4(1H)-PYRIDINONE 3-[(2-CHLORO-6-FLUOROBENZYL)OXY]-2-METHYL-1-(4-NITROBENZYL)-4(1H)-PYRIDINONE 1-(2-CHLORO-6-FLUOROBENZYL)-3-[(2-CHLORO-6-FLUOROBENZYL)OXY]-2-METHYL-4(1H)-PYRIDINONE 1-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-3-([3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]OXY)-2-METHYL-4(1H)-PYRIDINONE 3-[(2-CHLORO-6-FLUOROBENZYL)OXY]-2-METHYL-1-(4-METHYLBENZYL)-4(1H)-PYRIDINONE 3-[(2,6-DICHLOROBENZYL)OXY]-2-METHYL-1-(4-METHYLBENZYL)-4(1H)-PYRIDINONE 1-(3,4-DICHLOROBENZYL)-3-[(2,6-DICHLOROBENZYL)OXY]-2-METHYL-4(1H)-PYRIDINONE 3-(BENZYLOXY)-1-(2-CHLORO-6-FLUOROBENZYL)-2-METHYL-4(1H)-PYRIDINONE 3-[(4-CHLOROBENZYL)OXY]-1-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-2-METHYL-4(1H)-PYRIDINONE 1-BENZYL-3-[(2-CHLORO-6-FLUOROBENZYL)OXY]-2-METHYL-4(1H)-PYRIDINONE 1-(4-CHLOROBENZYL)-3-[(2-CHLORO-6-FLUOROBENZYL)OXY]-2-METHYL-4(1H)-PYRIDINONE 3-[(2,6-DICHLOROBENZYL)OXY]-1-(4-FLUOROBENZYL)-2-METHYL-4(1H)-PYRIDINONE 3-[(2-CHLORO-6-FLUOROBENZYL)OXY]-2-METHYL-1-(3-NITRO-2-PYRIDINYL)-4(1H)-PYRIDINONE

  • L1
  • DMHP
  • DEFERIDONE
  • DEFERIPRON
  • DEFERIPRONE
  • CP20
  • 3-HYDROXY-1,2-DIMETHYL-4(1H)PYRIDINONE
  • 3-HYDROXY-1,2-DIMETHYL-4(1H)-PYRIDONE
  • TIMTEC-BB SBB006753
  • 1,2-DIMETHYL-3-HYDROXY-4-PYRIDONE
  • 1,2-DIMETHYL-3-HYDROXYPYRID-4-ONE
  • 1,2-DIMETHYL-3-HYDROXYPYRIDIN-4-ONE
  • 1,2-DIMETHYL-3-HYDROXYPYRIDINE-4-ONE
  • 1,2-dimethyl-3-hydroxy-4(1h)-pyridinon
  • 1,2-dimethyl-3-hydroxy-4(1h)-pyridinone
  • 3-Hydroxy-1,2-dimethyl-1,4-dihydropyridin-4-one
  • 3-hydroxy-1,2-dimethyl-4(1h)-pyridon
  • cp20(chelatingagent)
  • 3-HYDROXY-1,2-DIMETHYL-4(1H)-PYRIDONE, 9 8%
  • deferiprone(DFP)
  • 3-Hydroxy-1,2-dimethyl-4(1H)-pyridone, 98.5%
  • 1,2-Dimethyl-3-hydroxy-4-pyridone, 99+%
  • Kelfer
  • 1,2-DiMethyl-3-hydroxy-4-pyridone, 99+% 10GR
  • 4(1H)-Pyridinone,3-hydroxy-1,2-diMethyl-
  • 1,2-Dimethyl-3-hydroxy-1,4-dihydropyridine-4-one
  • 3-Hydroxy-1,2-diMethylpyridin-4(1H)-one
  • DEFERIPRONE PHARMACEUTICAL RAW MATERIALS
  • Deferiprone CRS
  • 3-Hydroxy-1,2-dimethyl-4(1H)-pyridone&gt
  • eferiprone
  • Deferiprone ISO 9001：2015 REACH
  • DeferiproneQ: What is Deferiprone Q: What is the CAS Number of Deferiprone Q: What is the storage condition of Deferiprone Q: What are the applications of Deferiprone
  • 3-hydroxy-1,2-dimethylpyridin-4-one
  • Debrisoquine Hemisulfate-13C
  • 3-Hydroxy-1,2-dimethyl-4(1H)-pyridone, ≥ 98.0%
  • Deferrone
  • Deferiprone, 10 mM in DMSO
  • 30652-11-0
  • C7H9NO2
  • ALCOHOL
  • Building Blocks
  • Heterocyclic Building Blocks
  • Piperidones
  • Heterocycles
  • API intermediates
  • Chelating Agents, Ligands
  • Chelating Agents & Ligands
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Building Blocks
  • Heterocyclic Building Blocks
  • Piperidones