ChemicalBook > CAS DataBase List > Deferiprone

Deferiprone

Product Name
Deferiprone
CAS No.
30652-11-0
Chemical Name
Deferiprone
Synonyms
L1;CP20;DMHP;Kelfer;DEFERIPRON;DEFERIDONE;eferiprone;DEFERIPRONE;Deferiprone CRS;deferiprone(DFP)
CBNumber
CB0308124
Molecular Formula
C7H9NO2
Formula Weight
139.15
MOL File
30652-11-0.mol
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Deferiprone Property

Melting point:
272-275 °C (lit.)
Boiling point:
255.1°C (rough estimate)
Density 
1.1997 (rough estimate)
refractive index 
1.4800 (estimate)
storage temp. 
2-8°C
solubility 
Soluble in Water (up to 5 mg/ml with warming).
form 
Crystalline Powder or Needles
pka
pKa1 3.3, pKa2 9.7(at 25℃)
color 
White to off-white
Water Solubility 
Soluble in hot water
Merck 
14,2859
Stability:
Stable for 1 year from date of purchase as supplied. Solutions are not stable and must be prepared fresh daily.
InChI
InChI=1S/C7H9NO2/c1-5-7(10)6(9)3-4-8(5)2/h3-4,10H,1-2H3
InChIKey
TZXKOCQBRNJULO-UHFFFAOYSA-N
SMILES
C1(C)N(C)C=CC(=O)C=1O
CAS DataBase Reference
30652-11-0(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
26-36-37/39
WGK Germany 
3
RTECS 
UU7785940
HS Code 
29333990
Hazardous Substances Data
30652-11-0(Hazardous Substances Data)
Toxicity
LD50 i.p. in rats, mice: 650 mg/kg, 0.8-1.0 g/kg; i.g. in rats: 2.0-3.0 g/kg (Kontoghiorghes, 1995)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
379409
Product name
3-Hydroxy-1,2-dimethyl-4(1H)-pyridone
Purity
98%
Packaging
5g
Price
$76.8
Updated
2024/03/01
Sigma-Aldrich
Product number
379409
Product name
3-Hydroxy-1,2-dimethyl-4(1H)-pyridone
Purity
98%
Packaging
25g
Price
$233
Updated
2024/03/01
TCI Chemical
Product number
H0944
Product name
3-Hydroxy-1,2-dimethyl-4(1H)-pyridone
Purity
>98.0%(T)
Packaging
5g
Price
$80
Updated
2024/03/01
TCI Chemical
Product number
H0944
Product name
3-Hydroxy-1,2-dimethyl-4(1H)-pyridone
Purity
>98.0%(T)
Packaging
25g
Price
$230
Updated
2024/03/01
Cayman Chemical
Product number
20387
Product name
Deferiprone
Purity
≥95%
Packaging
1g
Price
$32
Updated
2024/03/01
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Deferiprone Chemical Properties,Usage,Production

Description

Deferiprone is a lipophilic iron chelator that binds to iron at a molar ratio of 3:1 (ligand: iron). Its active form is available orally, making it the only oral iron chelator. Deferiprone is a member of the 4-pyridone family and is a pyridine 4-4 (1H) -one, with a methyl substitution at positions 1 and 2 and a hydroxyl substitution at position 3. By binding to iron, Deferiprone can remove excess iron from the body and prevent serum iron overload in patients with transfusion-dependent thalassemia. It has chelation and protective effects and is primarily used to treat thalassaemia.

Chemical Properties

White Needles

Originator

Cipla (India)

Uses

3-Hydroxy-1,2-dimethyl-4(1H)-pyridone (OH-pyridone) may be used in the bacterial killing assays. It has been employed as hydroxyketone chelating agent and its cytotoxic action against oral human normal and tumor cell lines has been evaluated.

Uses

A chelator that could replace disferrioxamine. It is orally and parenterally effective in the removal of iron in vivo from rabbits and mice and also from transferrin and ferritin in vitro

Definition

ChEBI: Deferiprone is a member of the class of 4-pyridones that is pyridin-4(1H)-one substituted at positions 1 and 2 by methyl groups and at position 3 by a hydroxy group. A lipid-soluble iron-chelator used for treatment of thalassaemia. It has a role as an iron chelator and a protective agent.

brand name

Kelfer

General Description

3-Hydroxy-1,2-dimethyl-4(1H)-pyridone (Hdpp, Deferiprone) is a hydroxy ketone derivative. It reacts with uranyl salts [UO2(NO3)2] in aqueous acidic solution to afford mono nuclear complexes ([UO2(dpp)(Hdpp)2(H2O)]ClO4). X-ray studies have been conducted to examine the structure and geometry of these complexes.

Clinical Use

Orally administered chelator:
Treatment of transfusional iron overload

Metabolism

Deferiprone is hepatically metabolised to an inactive glucuronide metabolite and is excreted mainly in the urine as the metabolite and the iron-deferiprone complex, with a small amount of unchanged drug.

References

1) Hider and Hoffbrand (2018),?The Role of Deferiprone in Iron Chelation; N. Engl. J. Med.,?379?2140 2) Sripetchwandee?et al.?(2016),?A combination of an iron chelator with an antioxidant effectively diminishes the dendritic loss, tau-hyperphosphorylation, amyloid-β accumulation and brain mitochondrial dynamic disruption in rats with chronic iron-overload., Neuroscience?332?191 3) Liu?et al.?(2018),?Iron and Alzheimer’s Disease: From Pathogenesis to Therapeutic Implications;?Front. Neurosci,?12?632

Deferiprone Preparation Products And Raw materials

Raw materials

Preparation Products

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Deferiprone Suppliers

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View Lastest Price from Deferiprone manufacturers

Henan Research New Materials Co., Ltd.
Product
3-Hydroxy-1,2-dimethyl-4(1H)-pyridone 30652-11-0
Price
US $0.00-0.00/Kg
Min. Order
1Kg
Purity
99%
Supply Ability
1000kg
Release date
2024-07-22
shandong perfect biotechnology co.ltd
Product
Deferiprone 30652-11-0
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98% HPLC
Supply Ability
5 ton
Release date
2023-07-04
Hebei Weibang Biotechnology Co., Ltd
Product
Deferiprone 30652-11-0
Price
US $100.00/KG
Min. Order
1KG
Purity
99%min
Supply Ability
20 TON
Release date
2024-10-31

30652-11-0, DeferiproneRelated Search:

Deferiprone 4-HYDROXYPYRIDINE 3-Hydroxypyridine 1-BENZYL-3-[(2,6-DICHLOROBENZYL)OXY]-2-METHYL-4(1H)-PYRIDINONE 1-(2-CHLORO-6-FLUOROBENZYL)-3-[(2,6-DICHLOROBENZYL)OXY]-2-METHYL-4(1H)-PYRIDINONE 3-[(2-CHLORO-6-FLUOROBENZYL)OXY]-1-(4-FLUOROBENZYL)-2-METHYL-4(1H)-PYRIDINONE 3-[(2-CHLORO-6-FLUOROBENZYL)OXY]-2-METHYL-1-(4-NITROBENZYL)-4(1H)-PYRIDINONE 1-(2-CHLORO-6-FLUOROBENZYL)-3-[(2-CHLORO-6-FLUOROBENZYL)OXY]-2-METHYL-4(1H)-PYRIDINONE 1-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-3-([3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]OXY)-2-METHYL-4(1H)-PYRIDINONE 3-[(2-CHLORO-6-FLUOROBENZYL)OXY]-2-METHYL-1-(4-METHYLBENZYL)-4(1H)-PYRIDINONE 3-[(2,6-DICHLOROBENZYL)OXY]-2-METHYL-1-(4-METHYLBENZYL)-4(1H)-PYRIDINONE 1-(3,4-DICHLOROBENZYL)-3-[(2,6-DICHLOROBENZYL)OXY]-2-METHYL-4(1H)-PYRIDINONE 3-(BENZYLOXY)-1-(2-CHLORO-6-FLUOROBENZYL)-2-METHYL-4(1H)-PYRIDINONE 3-[(4-CHLOROBENZYL)OXY]-1-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-2-METHYL-4(1H)-PYRIDINONE 1-BENZYL-3-[(2-CHLORO-6-FLUOROBENZYL)OXY]-2-METHYL-4(1H)-PYRIDINONE 1-(4-CHLOROBENZYL)-3-[(2-CHLORO-6-FLUOROBENZYL)OXY]-2-METHYL-4(1H)-PYRIDINONE 3-[(2,6-DICHLOROBENZYL)OXY]-1-(4-FLUOROBENZYL)-2-METHYL-4(1H)-PYRIDINONE 3-[(2-CHLORO-6-FLUOROBENZYL)OXY]-2-METHYL-1-(3-NITRO-2-PYRIDINYL)-4(1H)-PYRIDINONE

  • L1
  • DMHP
  • DEFERIDONE
  • DEFERIPRON
  • DEFERIPRONE
  • CP20
  • 3-HYDROXY-1,2-DIMETHYL-4(1H)PYRIDINONE
  • 3-HYDROXY-1,2-DIMETHYL-4(1H)-PYRIDONE
  • TIMTEC-BB SBB006753
  • 1,2-DIMETHYL-3-HYDROXY-4-PYRIDONE
  • 1,2-DIMETHYL-3-HYDROXYPYRID-4-ONE
  • 1,2-DIMETHYL-3-HYDROXYPYRIDIN-4-ONE
  • 1,2-DIMETHYL-3-HYDROXYPYRIDINE-4-ONE
  • 1,2-dimethyl-3-hydroxy-4(1h)-pyridinon
  • 1,2-dimethyl-3-hydroxy-4(1h)-pyridinone
  • 3-Hydroxy-1,2-dimethyl-1,4-dihydropyridin-4-one
  • 3-hydroxy-1,2-dimethyl-4(1h)-pyridon
  • cp20(chelatingagent)
  • 3-HYDROXY-1,2-DIMETHYL-4(1H)-PYRIDONE, 9 8%
  • deferiprone(DFP)
  • 3-Hydroxy-1,2-dimethyl-4(1H)-pyridone, 98.5%
  • 1,2-Dimethyl-3-hydroxy-4-pyridone, 99+%
  • Kelfer
  • 1,2-DiMethyl-3-hydroxy-4-pyridone, 99+% 10GR
  • 4(1H)-Pyridinone,3-hydroxy-1,2-diMethyl-
  • 1,2-Dimethyl-3-hydroxy-1,4-dihydropyridine-4-one
  • 3-Hydroxy-1,2-diMethylpyridin-4(1H)-one
  • DEFERIPRONE PHARMACEUTICAL RAW MATERIALS
  • Deferiprone CRS
  • 3-Hydroxy-1,2-dimethyl-4(1H)-pyridone&gt
  • eferiprone
  • Deferiprone ISO 9001：2015 REACH
  • DeferiproneQ: What is Deferiprone Q: What is the CAS Number of Deferiprone Q: What is the storage condition of Deferiprone Q: What are the applications of Deferiprone
  • 3-hydroxy-1,2-dimethylpyridin-4-one
  • Debrisoquine Hemisulfate-13C
  • 3-Hydroxy-1,2-dimethyl-4(1H)-pyridone, ≥ 98.0%
  • 30652-11-0
  • C7H9NO2
  • ALCOHOL
  • Building Blocks
  • Heterocyclic Building Blocks
  • Piperidones
  • Heterocycles
  • API intermediates
  • Chelating Agents, Ligands
  • Chelating Agents & Ligands
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Building Blocks
  • Heterocyclic Building Blocks
  • Piperidones