N-BOC-1-[4-SPIRO-PIPERIDINE]-3-INDANONE
- Product Name
- N-BOC-1-[4-SPIRO-PIPERIDINE]-3-INDANONE
- CAS No.
- 159634-59-0
- Chemical Name
- N-BOC-1-[4-SPIRO-PIPERIDINE]-3-INDANONE
- Synonyms
- Caboxylate;N-BOC-1-[4-SPIRO-PIPERIDINE]-3-INDANONE;1’-Boc-3-oxo-2,3-dihydrospiro[indene-1,4’-piperidine;1'-Boc-3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine];tert-butyl 3-oxo-2,3-dihydro-1'H-spiro[indene-1,4'-piperidin...;tert-butyl 3-oxospiro[2H-indene-1,4'-piperidine]-1'-carboxylate;tert-butyl 3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-car;tert-Butyl 3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate;tert-Butyl 3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate;tert-Butyl 2,3-dihydro-3-oxospiro[1H-indene-1,4'-piperidine]-1'-carboxylate
- CBNumber
- CB0308700
- Molecular Formula
- C18H23NO3
- Formula Weight
- 301.38
- MOL File
- 159634-59-0.mol
N-BOC-1-[4-SPIRO-PIPERIDINE]-3-INDANONE Property
- Melting point:
- 120-122 °C(Solv: ethyl acetate (141-78-6); ligroine (8032-32-4))
- Boiling point:
- 439.8±45.0 °C(Predicted)
- Density
- 1.17
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- pka
- -0.80±0.20(Predicted)
- Appearance
- White to yellow Solid
Safety
- HazardClass
- IRRITANT
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- FB148533
- Product name
- tert-Butyl3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate
- Packaging
- 25mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FB148533
- Product name
- tert-Butyl3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate
- Packaging
- 50mg
- Price
- $105
- Updated
- 2021/12/16
- Product number
- 8032AA
- Product name
- tert-Butyl3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate
- Packaging
- 250mg
- Price
- $157
- Updated
- 2021/12/16
- Product number
- FB148533
- Product name
- tert-Butyl3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate
- Packaging
- 100mg
- Price
- $182
- Updated
- 2021/12/16
- Product number
- 060049
- Product name
- tert-Butyl 3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate
- Purity
- 99%
- Packaging
- 500mg
- Price
- $250
- Updated
- 2021/12/16
N-BOC-1-[4-SPIRO-PIPERIDINE]-3-INDANONE Chemical Properties,Usage,Production
Synthesis
185525-42-2
159634-59-0
Tert-butyl 3-hydroxyspiro[indene-1,4'-piperidine]-1'-carboxylate (20 g, 66 mmol) was used as a raw material, which was dissolved in ethyl acetate (300 mL) and o-iodobenzoic acid (IBX) (37 g, 132 mmol) was added with stirring. The reaction mixture was heated to 80 °C for 12 hours. After completion of the reaction, the mixture was cooled to room temperature and the solid was separated by filtration. The filter cake was washed well with ethyl acetate (3 x 100 mL). The filtrate and washings were combined and concentrated under reduced pressure to give a solid residue. The residue was purified by silica gel column chromatography, first eluting with a 1:10 solvent mixture of ethyl acetate-hexane, and then switching to a 1:3 solvent mixture of ethyl acetate-hexane, to give 1'-(tert-butoxycarbonyl)-spiro-(indene-1,4'-piperidinium) (19.5 g, 98% yield) as a white solid with a melting point of 121 °C. The residue was purified by IR (KBr). The product was characterized by IR (KBr), 1H NMR (CDCl3,400 MHz), 13C NMR (CDCl3,100 MHz) and GC-MS (EI) to confirm its structure.
References
[1] Patent: WO2008/68159, 2008, A1. Location in patent: Page/Page column 28; 30
[2] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 1, p. 363 - 366
[3] Patent: WO2009/61681, 2009, A2. Location in patent: Page/Page column 65
N-BOC-1-[4-SPIRO-PIPERIDINE]-3-INDANONE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from N-BOC-1-[4-SPIRO-PIPERIDINE]-3-INDANONE manufacturers
- Product
- N-BOC-1-[4-SPIRO-PIPERIDINE]-3-INDANONE 159634-59-0
- Price
- US $6.68/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg-1000kg
- Release date
- 2020-01-10