ChemicalBook > CAS DataBase List > N-BOC-1-[4-SPIRO-PIPERIDINE]-3-INDANONE

N-BOC-1-[4-SPIRO-PIPERIDINE]-3-INDANONE

Product Name
N-BOC-1-[4-SPIRO-PIPERIDINE]-3-INDANONE
CAS No.
159634-59-0
Chemical Name
N-BOC-1-[4-SPIRO-PIPERIDINE]-3-INDANONE
Synonyms
Caboxylate;N-BOC-1-[4-SPIRO-PIPERIDINE]-3-INDANONE;1’-Boc-3-oxo-2,3-dihydrospiro[indene-1,4’-piperidine;1'-Boc-3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine];tert-butyl 3-oxo-2,3-dihydro-1'H-spiro[indene-1,4'-piperidin...;tert-butyl 3-oxospiro[2H-indene-1,4'-piperidine]-1'-carboxylate;tert-butyl 3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-car;tert-Butyl 3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate;tert-Butyl 3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate;tert-Butyl 2,3-dihydro-3-oxospiro[1H-indene-1,4'-piperidine]-1'-carboxylate
CBNumber
CB0308700
Molecular Formula
C18H23NO3
Formula Weight
301.38
MOL File
159634-59-0.mol
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N-BOC-1-[4-SPIRO-PIPERIDINE]-3-INDANONE Property

Melting point:
120-122 °C(Solv: ethyl acetate (141-78-6); ligroine (8032-32-4))
Boiling point:
439.8±45.0 °C(Predicted)
Density 
1.17
storage temp. 
Sealed in dry,Store in freezer, under -20°C
pka
-0.80±0.20(Predicted)
Appearance
White to yellow Solid
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Safety

HazardClass 
IRRITANT
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Biosynth Carbosynth
Product number
FB148533
Product name
tert-Butyl3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate
Packaging
25mg
Price
$60
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB148533
Product name
tert-Butyl3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate
Packaging
50mg
Price
$105
Updated
2021/12/16
AK Scientific
Product number
8032AA
Product name
tert-Butyl3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate
Packaging
250mg
Price
$157
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB148533
Product name
tert-Butyl3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate
Packaging
100mg
Price
$182
Updated
2021/12/16
Matrix Scientific
Product number
060049
Product name
tert-Butyl 3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate
Purity
99%
Packaging
500mg
Price
$250
Updated
2021/12/16
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N-BOC-1-[4-SPIRO-PIPERIDINE]-3-INDANONE Chemical Properties,Usage,Production

Synthesis

185525-42-2

159634-59-0

Tert-butyl 3-hydroxyspiro[indene-1,4'-piperidine]-1'-carboxylate (20 g, 66 mmol) was used as a raw material, which was dissolved in ethyl acetate (300 mL) and o-iodobenzoic acid (IBX) (37 g, 132 mmol) was added with stirring. The reaction mixture was heated to 80 °C for 12 hours. After completion of the reaction, the mixture was cooled to room temperature and the solid was separated by filtration. The filter cake was washed well with ethyl acetate (3 x 100 mL). The filtrate and washings were combined and concentrated under reduced pressure to give a solid residue. The residue was purified by silica gel column chromatography, first eluting with a 1:10 solvent mixture of ethyl acetate-hexane, and then switching to a 1:3 solvent mixture of ethyl acetate-hexane, to give 1'-(tert-butoxycarbonyl)-spiro-(indene-1,4'-piperidinium) (19.5 g, 98% yield) as a white solid with a melting point of 121 °C. The residue was purified by IR (KBr). The product was characterized by IR (KBr), 1H NMR (CDCl3,400 MHz), 13C NMR (CDCl3,100 MHz) and GC-MS (EI) to confirm its structure.

References

[1] Patent: WO2008/68159, 2008, A1. Location in patent: Page/Page column 28; 30
[2] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 1, p. 363 - 366
[3] Patent: WO2009/61681, 2009, A2. Location in patent: Page/Page column 65

N-BOC-1-[4-SPIRO-PIPERIDINE]-3-INDANONE Preparation Products And Raw materials

Raw materials

Preparation Products

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N-BOC-1-[4-SPIRO-PIPERIDINE]-3-INDANONE Suppliers

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View Lastest Price from N-BOC-1-[4-SPIRO-PIPERIDINE]-3-INDANONE manufacturers

Career Henan Chemical Co
Product
N-BOC-1-[4-SPIRO-PIPERIDINE]-3-INDANONE 159634-59-0
Price
US $6.68/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
1kg-1000kg
Release date
2020-01-10

159634-59-0, N-BOC-1-[4-SPIRO-PIPERIDINE]-3-INDANONERelated Search:

TERT-BUTYL 6-FLUORO-3-OXO-2,3-DIHYDROSPIRO[INDENE-1,4'-PIPERIDINE]-1'-CARBOXYLATE N-BOC-1-[4-SPIRO-PIPERIDINE]-3-INDANONE TERT-BUTYL 3-OXO-6-(TRIFLUOROMETHYL)-2,3-DIHYDROSPIRO[INDENE-1,4'-PIPERIDINE]-1'-CARBOXYLATE TERT-BUTYL 6-METHOXY-3-OXO-2,3-DIHYDROSPIRO[INDENE-1,4'-PIPERIDINE]-1'-CARBOXYLATE TERT-BUTYL 5-FLUORO-3-OXO-2,3-DIHYDROSPIRO[INDENE-1,4'-PIPERIDINE]-1'-CARBOXYLATE TERT-BUTYL 5-CYANO-3-OXO-2,3-DIHYDROSPIRO[INDENE-1,4'-PIPERIDINE]-1'-CARBOXYLATE TERT-BUTYL 7-CYANO-3-OXO-2,3-DIHYDROSPIRO[INDENE-1,4'-PIPERIDINE]-1'-CARBOXYLATE TERT-BUTYL 4-METHOXY-3-OXO-2,3-DIHYDROSPIRO[INDENE-1,4'-PIPERIDINE]-1'-CARBOXYLATE TERT-BUTYL 6-CHLORO-3-OXO-2,3-DIHYDROSPIRO[INDENE-1,4'-PIPERIDINE]-1'-CARBOXYLATE TERT-BUTYL 4-CYANO-3-OXO-2,3-DIHYDROSPIRO[INDENE-1,4'-PIPERIDINE]-1'-CARBOXYLATE TERT-BUTYL 7-CHLORO-3-OXO-2,3-DIHYDROSPIRO[INDENE-1,4'-PIPERIDINE]-1'-CARBOXYLATE TERT-BUTYL 6-CYANO-3-OXO-2,3-DIHYDROSPIRO[INDENE-1,4'-PIPERIDINE]-1'-CARBOXYLATE TERT-BUTYL 7-METHOXY-3-OXO-2,3-DIHYDROSPIRO[INDENE-1,4'-PIPERIDINE]-1'-CARBOXYLATE TERT-BUTYL 5-METHOXY-3-OXO-2,3-DIHYDROSPIRO[INDENE-1,4'-PIPERIDINE]-1'-CARBOXYLATE TERT-BUTYL 3-OXO-4-(TRIFLUOROMETHYL)-2,3-DIHYDROSPIRO[INDENE-1,4'-PIPERIDINE]-1'-CARBOXYLATE TERT-BUTYL 4-FLUORO-3-OXO-2,3-DIHYDROSPIRO[INDENE-1,4'-PIPERIDINE]-1'-CARBOXYLATE TERT-BUTYL 5-CHLORO-3-OXO-2,3-DIHYDROSPIRO[INDENE-1,4'-PIPERIDINE]-1'-CARBOXYLATE TERT-BUTYL 4-CHLORO-3-OXO-2,3-DIHYDROSPIRO[INDENE-1,4'-PIPERIDINE]-1'-CARBOXYLATE

  • 2,3-Dihydro-3-oxo-spiro[1H-indene-1,4'-piperidine]-1'-carboxylic acid tert-butyl ester
  • N-BOC-1-[4-SPIRO-PIPERIDINE]-3-INDANONE
  • tert-butyl 3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-car
  • Spiro[1H-indene-1,4'-piperidine]-1'-carboxylic acid, 2,3-dihydro-3-oxo- 1,1-diMethyl ethyl ester
  • Caboxylate
  • 1'-Boc-3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]
  • 2,3-dihydro-3-oxo-spiro[1H-indene-1,4'-piperidine]-1'-carboxylic acid 1,1-dimethylethyl ester
  • tert-butyl 3-oxospiro[2H-indene-1,4'-piperidine]-1'-carboxylate
  • tert-butyl 3-oxo-2,3-dihydro-1'H-spiro[indene-1,4'-piperidine]-1'-carboxylate
  • tert-butyl 3-oxo-2,3-dihydro-1'H-spiro[indene-1,4'-piperidin...
  • 1,1-Dimethylethyl 2,3-dihydro-3-oxospiro[1H-indene-1,4'-piperidine]-1'-carboxylate
  • 1’-Boc-3-oxo-2,3-dihydrospiro[indene-1,4’-piperidine
  • tert-Butyl 3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate
  • tert-Butyl 3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate
  • tert-Butyl 2,3-dihydro-3-oxospiro[1H-indene-1,4'-piperidine]-1'-carboxylate
  • 159634-59-0