1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE

Product Name: 1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE
CAS No.: 57060-88-5
Chemical Name: 1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE
Synonyms: DL-Tic-OMe.HCl;(S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic;METHYLTETRAHYDROISOQUINOLINE CARBOXYLATEHYDROCHLORIDE;Methyl 1,2,3,4-tetrahydro-3-isoquinolinecarboxylate hydrochloride;METHYL 1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLATE HYDROCHLORIDE;S-(-)-1,2,3,4-Tetrahydro-3-IsoquinolinecarboxylicAcidMethylEsterHcl;(S)-Methyl 1,2,3,4-tetrahydroisoquinoline-3-carboxylate hydrochloride;1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE;3-ISOQUINOLINECARBOXYLIC ACID, 1,2,3,4-TETRAHYDRO-, METHYL ESTER, HYDROCHLORIDE;1,2,3,4-tetrahydro-3-Isoquinolinecarboxylic acid methyl ester, hydrochloride (1:1)
CBNumber: CB0310222
Molecular Formula: C11H14ClNO2
Formula Weight: 227.69
MOL File: 57060-88-5.mol

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1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE Property

storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
Appearance: White to off-white Solid
CAS DataBase Reference: 57060-88-5(CAS DataBase Reference)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P363Wash contaminated clothing before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: M338023
Product name: Methyl1,2,3,4-tetrahydroisoquinoline-3-carboxylatehydrochloride
Packaging: 50mg
Price: $45
Updated: 2021/12/16

Ark Pharm

Product number: P000102631
Product name: Methyl 1,2,3,4-tetrahydroisoquinoline-3-carboxylate hydrochloride
Purity: 97%
Packaging: 250mg
Price: $24
Updated: 2021/12/16

Ark Pharm

Product number: P000102631
Product name: Methyl 1,2,3,4-tetrahydroisoquinoline-3-carboxylate hydrochloride
Purity: 97%
Packaging: 1g
Price: $59
Updated: 2021/12/16

Ark Pharm

Product number: P000102631
Product name: Methyl 1,2,3,4-tetrahydroisoquinoline-3-carboxylate hydrochloride
Purity: 97%
Packaging: 5g
Price: $249
Updated: 2021/12/16

Ark Pharm

Product number: P000102631
Product name: Methyl 1,2,3,4-tetrahydroisoquinoline-3-carboxylate hydrochloride
Purity: 97%
Packaging: 10g
Price: $422
Updated: 2021/12/16

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1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE Chemical Properties,Usage,Production

Synthesis

67123-97-1

57060-88-5

GENERAL PROCEDURE: The chiral monomer (R)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (4.27 g, 20 mmol) was dissolved in methanol (20 mL) and the solution was cooled to 0 °C. Thionyl chloride (5.2 mL) was added slowly and dropwise with stirring. The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the solvent was removed by rotary evaporator under reduced pressure to afford the white solid product (R)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid methyl ester hydrochloride (5.29 g, 94.4% yield). The product was confirmed by 1H NMR (300 MHz, D2O, rt): δ 7.45-7.24 (m, 4H), 4.60 (d, J = 5.5 Hz, 1H), 4.56 (d, J = 5.4 Hz, 1H), 4.53 (br s, 1H), 3.93 (s, 3H), 3.53 (dd, J = 17.4, 5.5 Hz, 1H) 3.32 (dd, J = 17.3, 10.9 Hz, 1H). High resolution electrospray ionization mass spectrometry (HR ESIMS) showed m/z 192.1028 [M + H]+ (calculated value 192.1025), further confirming the structure of the product.

References

[1] European Journal of Medicinal Chemistry, 2016, vol. 121, p. 272 - 282

1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE Suppliers

China 58 Europe 2 Germany 3 India 2 United Kingdom 6 United States 14 Global 85

Meryer (Shanghai) Chemical Technology Co., Ltd.

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View Lastest Price from 1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: 1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE 57060-88-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Career Henan Chemical Co

Product: 1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE 57060-88-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2020-01-08

57060-88-5, 1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDERelated Search:

Quinapril benzyl ester maleate 1,2,3,4-TETRAHYDRO-ISOQUINOLINE-8-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE 1,2,3,4-TETRAHYDRO-ISOQUINOLINE-7-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE 1,2,3,4-TETRAHYDRO-ISOQUINOLINE-5-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE Benzyl (3S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate hydrochloride Benzyl (S)-(-)-1,2,3,4-tetrahydro-3-isoquinolinecarboxylate p-toluenesulfonic acid salt (S)-2-[(S)-2-((S)-1-Ethoxycarbonyl-3-phenylpropylamino)propionyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid benzyl ester Benzyl 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate L-ETHYL 1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLATE HYDROCHLORIDE CarboxylicAcidPhenylMethylEsterHydrochloride,QuinaprilHcl L-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE (S)-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINECARBOXYLIC ACID T-BUTYL ESTER (S)-6,7-DIMETHOXY-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINE CARBOXYLIC TERT BUTYL ESTER 1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE 6-Hydroxy-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acid methyl ester hydrochloride (S,S)-2-(2-AMINO-3-METHYL-BUTYRYL)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID BENZYL ESTER, HCL (S)-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINE-CARBOXYLIC ACID T-BUTYL ESTER PTSA SALT

METHYL 1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLATE HYDROCHLORIDE

METHYLTETRAHYDROISOQUINOLINE CARBOXYLATEHYDROCHLORIDE

1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE

3-ISOQUINOLINECARBOXYLIC ACID, 1,2,3,4-TETRAHYDRO-, METHYL ESTER, HYDROCHLORIDE

3-Isoquinolinecarboxylic acid, 1,2,3,4-tetrahydro-, methyl ester, hydrochloride (1:1)

Methyl 1,2,3,4-tetrahydro-3-isoquinolinecarboxylate hydrochloride

S-(-)-1,2,3,4-Tetrahydro-3-IsoquinolinecarboxylicAcidMethylEsterHcl

(S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic

(S)-Methyl 1,2,3,4-tetrahydroisoquinoline-3-carboxylate hydrochloride

DL-Tic-OMe.HCl

1,2,3,4-tetrahydro-3-Isoquinolinecarboxylic acid methyl ester, hydrochloride (1:1)

57060-88-5